Electronic Posters: Neuroimaging - ismrm

15:00 4265. 1H and 31P Spectroscopy: High Energy Metabolism in Idiopathic Parkinson
Syndrome
Elke Hattingen 1 , Ruediger Hilker 2 , Joerg Magerkurth 1 , Carola Seifried 2 , Ulrich Pilatus 1
1 Institute of Neuroradiology, University Hospital, Goethe University, Frankfurt, Germany; 2 Department of
Neurology, University Hospital, Goethe University, Frankfurt, Germany
Combined 31P and 1H spectroscopic imaging was used to study changes in midbrain energy metabolism of patients with Parkinsons
disease. Compared to healthy volunteers there is a decrease in high energy phospahtes (ATP an phosphocreatine). The effect is more
pronounced in the hemisphere contralateral to the clinacal more affected side. The results corroborate the hypothesis of a potential role
of mitochondrial dysfunction in Parkinsons disease.
Wednesday 13:30-15:30 Computer 73
13:30 4266. Proinflammatory Cytokines Correlate with Diffusion Tensor Imaging Derived
Metrics in Patients with Acute and Acute-On-Chronic Liver Failure
Santosh Kumar Yadav 1 , R Murali 2 , Vivek A. Saraswat 2 , R KS Rathore 3 , A Yadav 1 , K N.
Prasad 4 , M A. Thomas 5 , Rakesh Kumar Gupta 1
1 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;
2 Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;
3 Mathematics and Statistics, Indian Institute of technology Kanpur, Kanpur, Uttar Pradesh, India;
4 Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;
5 Radiological Sciences, UCLA School of Medicine, Los Angeles, CA, Los Angeles, CA, United States
Fourteen patients with ALF, 17 with ACLF and 8 age/sex matched controls were included in this study. MRI, 1H-MR spectroscopy
and serum proinflammatory cytokines measurements were done in all the patients and controls. Serum proinflammatory molecules
were significantly increased in both conditions as compared to controls. A significant positive correlation of CS with IL-6 and TNF-α
was observed in ALF while, CS correlated only to IL-6 in ACLF. A significant negative correlation was observed between MD values
and IL-6 in both conditions. A significant positive correlation was also observed among Glx/Cr, IL-6 and TNF-α in both conditions.
These observations suggest that proinflammatory cytokines may contribute in the development of CE in these patients.
14:00 4267. Absolute Quantification of Human Brain Metabolites in Gulf War Syndrome Using
Proton MR
Spectroscopy at 3T
Hyeon-Man Baek 1 , Sergey Cheshkov 1,2 , Audrey Chang 1 , Sandeep Ganji 1 , Evelyn
Babcock 1 , Richard Briggs 1,2 , Robert Haley 2
1 Radiology, UT Southwestern Medical Center, Dallas, TX, United States; 2 Internal Medicine, UT Southwestern
Medical Center, Dallas, TX, United States
In the present study, metabolic concentrations of three distinct Gulf War (GW) syndromes (e.g., Syndrome-I is described as “impaired
cognition;” syndrome-II, “confusion-ataxia; syndrome-III, “central pain”) were calculated and compared the findings with those for
healthy GW veterans. The main observation in this work was the significant reduction of NAA (Syndrome-I, -8%; Syndrome-II, -
11%; Syndrome-III, -4%) concentration in left BG and (Syndrome-I, -7%; Syndrome-II, -8%; Syndrome-III, -9%) in right BG of GW
syndrome subjects compared to healthy control subjects. The present study demonstrated that quantitative in vivo 1H-MRS can be
used to detect the brain abnormalities in GW illness veterans, which may have relevance for the mechanisms of Gulf War syndrome.
14:30 4268. Brain Diffusion-Weighted Imaging in Friedreich’s Ataxia
Giovanni Rizzo 1,2 , Caterina Tonon 1 , Maria Lucia Valentino 2 , David Neil Manners 1 ,
Filippo Fortuna 1,2 , Cinzia Gellera 3 , Antonella Pini 4 , Sandro Ghezzo 4 , Agostino Baruzzi 2 ,
Claudia Testa 1 , emil Malucelli 1 , Bruno Barbiroli 1 , Valerio Carelli 2 , Raffaele Lodi 1
1 MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna,
Bologna, BO, Italy; 2 Neurological Sciences, University of Bologna, Bologna, BO, Italy; 3 U.O. Biochemistry
and Genetics, Fondazione IRCCS-Istituto Neurologico Nazionale “Carlo Besta”, Milano, MI, Italy;
4 Neuropsichiatric Unit, Ospedale Maggiore, Bologna, BO, Italy
Objectives. To define the extent of the brain damage in FRDA and to identify in vivo markers of neurodegeneration, using DWI.
Methods. MD maps from 27 FRDA patients and 21 healthy volunteers were generated. ROI and histogram analysis was performed.
Results. MD values of patients were higher than controls in medulla, pons, MCP, SCP, pyramidal tracts, and OR, as well as in whole
brainstem, cerebellar hemispheres, cerebellar vermis and sovratentorial compartment, and correlated with genetic and clinical data.
Conclusions. Neurodegeneration in FRDA is more extensive than previously reported, and DWI is a suitable technique to provide
biomarkers of disease progression.