Electronic Posters: Neuroimaging - ismrm

Developing Brain I
Hall B Monday 14:00-16:00 Computer 80
14:00 4374. Static and Dynamic Characteristics of Resting State CBF in Newborn Infants
Feng Liu 1,2 , Zhishun Wang 1,2 , Yunsuo Duan 1,2 , Fernando Zelaya 3 , David J. Lythgoe 3 ,
Alayar Kangarlu 1,2 , Bradley S. Peterson 1,2
1 Psychiatry, Columbia University, New York, NY, United States; 2 New York State Psychiatric Institute, New
York, NY, United States; 3 Institute of Psychiatry, King’s College London, University of London, London,
United Kingdom
Resting-state networks in the infant brain have been studied recently using BOLD fMRI in order to better understand the early
developmental phase of default mode network. Perfusion MRI with arterial spin labeling (ASL) has been implemented to study
resting-state functional connectivity in the adult brain. We applied pulsed ASL on unsedated, sleeping newborns, and studied the static
and dynamic characteristics of cerebral blood flow (CBF) with a method using high-pass filtering and demodulation. We demonstrated
the ability to detect the functional connectivity using the CBF fluctuation extracted from ASL signals during the resting state of
newborns.
14:30 4375. The Dynamics of Brain and CSF Growth in Normal Versus Hydrocephalic
Development in a Mouse Model
Jason Gregory Mandell 1,2 , Thomas Neuberger 3 , Corina S. Drapaca 1 , Andrew G. Webb 4 ,
Steven J. Schiff 1,5
1 Center for Neural Engineering, Department of Engineering Science and Mechanics, Pennsylvania State
University, University Park, PA, United States; 2 Department of Bioengineering, Pennsylvania State University,
University Park, PA, United States; 3 Huck Institutes of the Life Sciences, Pennsylvania State University,
University Park, PA, United States; 4 C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden
University Medical Center, Leiden, Netherlands; 5 Departments of Neurosurgery and Physics, Pennsylvania
State University, University Park, PA, United States
Hydrocephalus has traditionally been quantified by linear measurements of ventricle size. However, clinical outcome is related to
brain cognitive function, which is more directly related to brain volume. We quantified brain and ventricular volume growth in normal
versus kaolin-induced hydrocephalic development in mice from ages 2-12 weeks using 14T MRI. Hydrocephalic mice responded with
brain growth either consistent with or faster than normal, correlating to the absence or presence of parenchymal edema. Clinical
measurements were unable to discriminate between these patterns, demonstrating the clinical importance of brain volume
measurements and the feasibility of constructing normative brain and fluid growth curves.
15:00 4376. CSF and Cerebral Blood Flows in Paediatric: Evaluation with Phase Contrast MRI
Olivier Balédent 1 , Véronique Courtois 2 , Béatrice Krepjowicz 2 , Julie Schauvliege 3 ,
Anthony Fichten 4 , Guy Kongolo 5 , Roger Bouzerar 1 , Catherine Gondry-Jouet 3
1 image processing, university hospital, Amiens, Picardie, France, Metropolitan; 2 Ecole supérieure d'ostéopathie
et de biomécanique, Paris; 3 radiology, university hospital, Amiens, Picardie, France, Metropolitan; 4 image
processing, neurosurgery, Amiens, Picardie, France, Metropolitan; 5 pediatry, university hospital, Amiens,
Picardie, France, Metropolitan
The purpose of this study is to quantify with PC-MRI, CSF and cerebral vascular flows maturation in paediatric population and
demonstrate how altered flows in children with hydrocephalus can be pointed. 36 children (5days-8years) were defined as a paediatric
control group. 6 newborns (9days-6weeks) with ventricular dilation associated to intra ventricular haemorrhage (IVH) were
individually studied. Arterial, venous, cervical CSF and aqueductal CSF flows were presented function of age. The 6 IVH newborn
presented alterations of their cerebral flows. Quantitative assessments of CSF and blood flows indicate the potential usefulness of PC-
MRI in paediatric hydrocephalus.
15:30 4377. Direct Phase Imaging in Neonate
Kai Zhong 1 , Lynn Anderson 2 , Linda Chang 2 , Thomas Ernst 2 , Oliver Speck 1
1 Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Saxon-Anhalt, Germany;
2 Department of Medicine, University of Hawaii, Honolulu, HI, United States
Direct phase images have been shown to yield superior gray (GM) and white matter (WM) contrast at high field compared to
conventional magnitude images. However, the contrast mechanisms are still being discussed. Previous studies are limited to high field
and adult volunteers or patients. In this study, phase imaging in neonates is demonstrated for the first time and provides insights to the
various factors contributing to phase contrast, such as water macromolecule exchange (WME) and myelination. Phase differences
between GM and WM are significantly reduced in neonates prior to myelination and seem to originate primarily from WME contrast.
Therefore, direct phase imaging can study brain development and related pathologies in neonates.