Electronic Posters: Neuroimaging - ismrm
Electronic Posters: Neuroimaging - ismrm
Electronic Posters: Neuroimaging - ismrm
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14:30 4519. Metabolite Abnormalities in Rhesus Monkeys During Withdrawal of<br />
Methamphetamine: A 1 H MR Spectroscopy Study at 3T<br />
Shaolin Yang 1 , Svetlana Chefer 1 , D. Bruce Vaupel 1 , Xi Chen 1 , Pradeep K. Kurup 1 ,<br />
Thomas J. Ross 1 , Elliot A. Stein 1 , Yihong Yang 1<br />
1 National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States<br />
A proton magnetic resonance spectroscopy ( 1 H-MRS) study was performed to examine the metabolite abnormalities in the Rhesus<br />
monkeys during the abstinence from a long history of methamphetamine (METH) self-administration. The 1 H-MRS spectral data were<br />
acquired from the frontal lobe and striatum of Rhesus monkeys at 3T in 5 separate sessions (1-day, 1-week, 1-month, 3-month, and 6month<br />
abstinence, respectively). Compared to the control group (n=5), the total choline (tCho) level in the striatum is significantly<br />
elevated during the early abstinence (up to 1 month) and continued to be elevated after 3 months of drug withdrawal in the METHabstinence<br />
group (n=10).<br />
15:00 4520. Brain Metabolites B1-Corrected Proton T1 Mapping in the Rhesus Macaque at 3T<br />
Songtao Liu 1 , Roman Fleysher 2 , Lazar Fleysher 2 , Chan-Gyu Joo 3 , Eva-Maria Ratai 3 , R<br />
Gilberto Gonzalez 3 , Oded Gonen 2<br />
1 National Institutes of Health Clinical Center, Bethesda, MD, United States; 2 New York University Medical<br />
Center, New York, NY, United States; 3 Massachusetts General Hospital, Boston, MA, United States<br />
The rhesus macaque brain is an advanced model system for the study of neurological diseases. To correct for unknown T1 weighting<br />
in MRS quantification, the B1 corrected T1s of NAA, Cho and Cr in gray and white matter structures of rhesus macaques were<br />
measured at 3T. Data was acquired with 3D multivoxel proton MRSI at 180uL resolution. The macaques’ NAA, Cr and Cho T1s are,<br />
1232, 1238 and 1107ms. These values are in agreement with human 3T in vivo results.<br />
15:30 4521. High Spatiotemporal Resolution for Molecular Imaging with BIRDS<br />
Daniel Coman 1,2 , Robin A. de Graaf 3 , Douglas L. Rothman, 23 , Fahmeed Hyder, 23<br />
1 Diagnostic Radiology, Yale University, New Haven, CT, United States; 2 Quantitative Neuroscience with<br />
Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States; 3 Diagnostic Radiology and<br />
Biomedical Engineering, Yale University, New Haven, CT, United States<br />
Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) is used for pH/temperature mapping in rat brain. The BIRDS method<br />
relies on strong dependence of non-exchangeable protons from thulium based macrocyclics, e.g., TmDOTP 5- and TmDOTMA - , for<br />
temperature and pH. Although high speed 2D CSI allows ~10μL voxels in rat’s cerebral cortex within 5 minutes, many applications<br />
require whole brain coverage and high spatiotemporal resolution. Here we demonstrate a 3D CSI of a 2.5×2.5×2.5 cm field-of-view<br />
with 1μL voxels in 5 minutes using reduced k-space spherical encoding, which represents an order of magnitude sensitivity<br />
enhancement from the 2D CSI data acquisition.<br />
Tuesday 13:30-15:30 Computer 89<br />
13:30 4522. Investigation of Spatial Distribution of Metabolites in Rat Brain at Elevated Plasma<br />
Glucose Levels<br />
Vladimir Mlynarik 1 , Cristina Cudalbu 1 , Hanne Frenkel 1 , Nicolas Costers 1,2 , Rolf<br />
Gruetter 1,3<br />
1 Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne,<br />
Switzerland; 2 Katholieke Universiteit Leuven, Leuven, Belgium; 3 Departments of Radiology, Universities of<br />
Lausanne and Geneva, Switzerland<br />
Absolute metabolic maps of 12 metabolites were obtained in rat brain at different plasma glucose (Glc) concentrations (6.4 – 19<br />
mmol/L) using short-echo-time proton spectroscopic imaging. A satisfactory linear fit of brain Glc concentration versus plasma Glc<br />
concentration in cortex, hippocampus and thalamus was found. The slope of this fit was the same within experimental error in all<br />
measured brain structures. The linear fit of increased lactate concentrations at increased plasma Glc levels was poor, indicating that<br />
other factors such as stress or impaired metabolism during long-term anesthesia can affect the lactate concentration in brain.<br />
Concentrations of myo-inositol, taurine, ascorbate, phosphoethanolamine, glutamine, GABA, N-acetylaspartate, total creatine, total<br />
choline and macromolecules were not substantially affected by acute hyperglycemia.<br />
14:00 4523. The Effect of Electroconvulsive Shock on the Neurochemical Profile in the Live Rat:<br />
Neurogenesis & Glutamate<br />
S. David Smith 1 , June-Hee Park 2 , Michael Ma 3 , Mei Yu 4 , Shaonan Zhang 3 , Mirjana<br />
Maletic-Savatic 5 , Annemie Van der Linden 6 , G. Enikolopov 2 , Helene Benveniste 4<br />
1 Medical, Brookhaven National Laboratory, Upton, NY, United States; 2 Cold Spring Harbor Laboratory, Cold<br />
Spring Harbor, NY, United States; 3 Stony Brook University, United States; 4 Anesthesiology, Stony Brook<br />
University, Stony Brook, NY, United States; 5 Baylor College of Medicine, TX, United States; 6 University of<br />
Antwerpen, Antwerpen, Belgium<br />
We tested the hypotheses that 1) the electroconvulsive shock (ECS) induced increase in the 1.28ppm neural stem cell biomarker could<br />
be tracked using LCModel software and 2) that ECS being an effective anti-depressant treatment would result in changes in glutamate<br />
detectable by LCModel software. Analysis of our 1HMRS data acquired from the rat dentate gyrus before and after ECS demonstrated<br />
that the 1.28ppm signal was too low to be tracked by LCModel software (CRLB