Electronic Posters: Neuroimaging - ismrm

Christie Hospital NHS Trust, Manchester, United Kingdom; 5 Division of Medical Physics, University of Leeds,
Leeds, United Kingdom
Dynamic contrast-enhanced (DCE-) MRI using a two-compartment exchange model (2CXM) can provide estimates of perfusion (Fb),
microvessel permeability-surface area (PS), interstitial volume (ve) and blood volume (vb). DCE-MRI parameters correlate with VEGF
expression, an initiator of angiogenesis and prognostic indicator, in a variety of tumours. Eight patients with head-and-neck cancer
underwent high temporal-resolution DCE-MRI before surgery. Whole-tumour concentration-time curves were analysed using the
2CXM to estimate Fb, PS, ve, vb and plasma mean transit time. VEGF mRNA expression was measured at surgery. Fb, ve and PS
correlated significantly with VEGF expression suggesting that DCE-MRI parameters may be indicative of angiogenesis.
14:30 4295. MRI of Head and Neck Patients in the Radiotherapy Treatment Position
Scott Hanvey 1 , John Foster 2
1 Radiotherapy Physics, Beatson West of Scotland Cancer Centre, Glasgow, Lanarkshire, United Kingdom;
2 MRI Physics, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom
Accurate localisation of the planning target volume (PTV) is vitally important in radiotherapy. The excellent soft tissue contrast of
MRI makes it an ideal imaging modality for radiotherapy of the head and neck. Registration of MRI with CT can be problematic
since patients are not positioned in the same way. The following study compared the accuracy of the registration of MRI with CT in
20 head and neck patients receiving an MRI in the typical curved table and within an immobilisation device. It also measured the
PTVs of patients in the normal and radiotherapy position in MRI.
15:00 4296. Prognostic Value of Minimum Apparent Diffusion Coefficient for Patients with
Hypopharyngeal Cancer
Yu-Chun Lin 1,2 , Su-Hang Ng 1 , Yau-Yau Wai 1 , You-Hsuan Tsai 3 , Jiun-Jie Wang 3
1 Department of Diagnostic Radiology, ChangGung Memorial Hospital, KweiShan, Taoyuan, Taiwan;
2 Department of Electrical Engineering, ChangGung University, KweiShan, Taoyuan, Taiwan; 3 Department of
Medical Imaging and Radiological Science, ChangGung University, KweiShan, Taoyuan, Taiwan
The minimum ADC reflects the highest cellularity within the tumor. In this study we proposed to assess the survival rates for patients
with hypopharyngeal cancer using minimum ADC, mean ADC and the tumor volume, which is the conventional standard. The
Kaplan-Meier survival analysis revealed that the minimum ADC can successfully predict the 16-month overall survival with a optimal
threshold of 6.94¡Ñ10-3 mm2/sec. Thus, the minimum ADC could serve as a biomarker for the prognosis in patients with
hypopharyngeal cancer.
15:30 4297. MRI Sialolithography: Direct Visualization of Calculi in the Submandibular Gland
Using SWI at 3T
Ali Fatemi 1 , Colm Boylan 2 , Judith Coret-Simon 2 , Michael D. Noseworthy, 23
1 Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada;
2 Diagnostic Imaging, St. Joseph's Healthcare, Hamilton, Ontario, Canada; 3 Electrical and Computer
Engineering, School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada
A technique is presented that allows for the specific identification and localization of calculi within glandular tissues or ducts using
MRI. The technique is based on positive phase filtered SWI, and does not require ionizing radiation or the use of sialogogue.
Tuesday 13:30-15:30 Computer 75
13:30 4298. T1 and T2 Relaxation Time Histograms of Mandibular Bone Marrow: A
Monomodal Distribution in
Sickle Cell Disease
Joseph Liao 1 , Nekou Nowrouzi 1 , Elliott Elias 1 , Hernan Jara 1 , Osamu Sakai 1
1 Boston Medical Center, Boston University School of Medicine, Boston, MA, United States
Purpose: To characterize sickle-cell disease-related changes in the mandibular bone marrow using qMRI relaxometry. Materials and
Methods: 13 SCD patients (19.8-43 years old) and 17 age-matched controls (23-64 years old) were imaged with the mixed turbo spinecho
pulse sequence. The mandible was manually segmented. T1 and T2 relaxation time histograms were created. Results: 15 of the
17 controls exhibited bimodal peaks in T1; all controls exhibited bimodal peaks in T2. In contrast, all SCD patients exhibited
monomodal peaks in both T1 and T2 sequences. Conclusion: qMRI relaxometry reveals a monomodal histogram distribution in the
bone marrow in SCD patients.
14:00 4299. Quantitative MRI Analysis of Lacrimal Glands in Patients with Sickle Cell Disease
Elliott Elias 1 , Joseph Liao 1 , Memi Watanabe 1 , Naoko Saito 1 , Hernan Jara 1 , Osamu
Sakai 1
1 Boston Medical Center, Boston University School of Medicine, Boston, MA, United States
Purpose: To analyze MR relaxometric and volumetric changes in lacrimal glands in sickle cell disease (SCD) as motivated by a recent
case report on lacrimal gland pathology. Materials and Methods: 15 SCD patients (19.8-43.6 yrs) and 23 control subjects (23-64 yrs)
were imaged by mixed-TSE sequence at 1.5T. T1, T2, and secular-T2 relaxation time histograms and volumes were analyzed. Results:
T2 and secular-T2 relaxation times were significantly shortened in SCD patients, and glandular volumes were increased. No
significant differences were observed in T1. Conclusion: Disease specific relaxometric and volumetric were observed in the lacrimal
glands of SCD patients.