Electronic Posters: Neuroimaging - ismrm

15:00 4392. Dti Study in the Infants Brain; Methodolgy and Validation in Infants with Hypoxic-
Ischemic-Encephalopathy
Moran Artzi 1,2 , Liat Ben Sira 3 , Haim Bassan 4 , Varda Gross-Tsur 5,6 , Irit Berger 7 , Ronella
Marom 7 , Yael Leitner 4 , Maya Weinstein 1,8 , Ronny Geva 9 , Dafna Ben Bashat 1
1 The Wohl Institute for Advanced Imaging, Brain Imaging Center, Tel Aviv Sourasky Medical Center, Tel-
Aviv, Israel; 2 Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel; 3 Department of Radiology ,
Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; 4 Pediatric Neurology and Child Development Unit, Tel
Aviv Sourasky Medical Center, Tel-Aviv, Israel; 5 Neuropediatric Unit, Shaare-Zedek Medical Center,
Jerusalem, Israel; 6 Department of Family Medicine, Hebrew University, Jerusalem, Israel; 7 Department of
Neonatology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; 8 Department of
Psychology, Gonda Multidisciplinary Brain Research Center, Bar Ilan University , Ramat-Gan , Israel;
9 Department of Psychology, Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat-Gan,
Israel
The ability to diagnose abnormal MR-signal in the infant's brain is challenging. The aim of this study is to present a methodology that
enables quantification and comparison between infants' brains, by creating a standard space that includes the imaging data and
templates and atlases adjusted to infants. Preliminary results of DTI in HIE infants with and without hypothermia (cooling to 33°c for
72 hours) compared with normal controls are presented, demonstrating the applicability of this methodology in the pathological brain.
Diffusivity values in different VOIs and histogram analysis show the effect of the therapeutic hypothermia in HIE.
15:30 4393. Abnormal Microstructure of the Thalamus in Childhood Survivors of Prematurity:
Assessment with Diffusion Tensor Imaging
Arabhi C. Nagasunder 1 , Hannah C. Kinney 2 , Caroline Jane Tavare 3 , Tena Rosser 4 , Floyd
H. Gilles 3 , Marvin D. Nelson 1 , Stefan Bluml 1,5 , Ashok Panigrahy 1,6
1 Department of Radiology, Childrens Hospital Los Angeles, Los Angeles, CA, United States; 2 Department of
Pathology, Children's Hospital of Boston, Boston, MA, United States; 3 Department of Neuropathology,
Childrens Hospital Los Angeles, Los Angeles, CA, United States; 4 Division of Neurology, Childrens Hospital
Los Angeles, Los Angeles, CA, United States; 5 Rudi Schulte Research Institute, Santa Barbara, CA, United
States; 6 Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States
Long-term survivors of prematurity with periventricular leukomalacia (PVL) suffer major cognitive deficits. One of the critical
structures is the thalamus which is involved in cognition via extensive interconnections with the cerebral cortex. The goal of this study
was to show combined volumetric and DTI data within the parenchyma of the thalamus in childhood survivors of prematurity with
PVL. We found significant atrophy in combination with microstructural abnormalities with preferential pulvinar injury.
Tuesday 13:30-15:30 Computer 81
13:30 4394. Value of Susceptibility-Weighted Imaging for Diagnosing Intracranial Hemorrhage
in Neonates According to Anatomic Location
Tetsu Niwa 1 , Taro Takahara 1 , Thomas Kwee 1 , Manon Benders 2 , Linda de Vries 2 , Vincent
O. Boer 1 , Freddy Visser 1 , Peter R. Luijten 1 , Floris Groenendaal 2
1 Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2 Neonatology, Wilhelmina Children’s
Hospital/University Medical Center Utrecht, Utrecht, Netherlands
Susceptibility-weighted imaging provides additional value for increasing certainty to detect or rule out hemorrhage in neonates
14:00 4395. Correlations Between Increased ASL Perfusion and Decreased ADC in Newborns
with Hypoxic Ischemia
Rudolph Pienaar 1,2 , Neel Madan, 23 , Patricia Ellen Grant 1,2
1 Radiology, Childrens Hospital Boston, Boston, MA, United States; 2 Radiology, Harvard Medical School,
Boston, MA, United States; 3 Radiology, Massachusetts General Hospital, Boston, MA, United States
We have developed a methodology to detect correlations between increased ASL-CBF perfusion and decreased ADC values in areas
of hypoxic ischemia
14:30 4396. Specific White Matter Diffusion Characteristics in the Newborn Period Correlate
with Either Neuromotor or Neurocognitive Outcome at 2 Years. a Voxel Based Analysis
Tamara Faundez 1 , Rebecca Recker 1 , Cristina Borradori Tolsa 1 , Gregory Lodygensky 1 ,
Francois Lazeyras 2,3 , Petra Susan Huppi 1
1 Division of Child Growth & Development, University of Geneva and University Hospitals, Geneva,
Switzerland; 2 Service of Radiology, University of Geneva and University Hospital of Geneva, Geneva,
Switzerland; 3 Center for Biomedical Imaging (CIBM), Lausanne and Geneva, Switzerland
The goal of this study is to assess by diffusion MRI, neonatal structural deficit of premature babies related to neurocognitive deficits
later in life. Using voxel-based analysis, we correlate ADC measures at birth with neuromotor and neurocognitive outcome at the age
of 2 years. We observed distinct ADC changes with respect to mental and physical scores. Mental score is correlated with regions
linked to future cognitive function like language. Neuromotor-related regions include precentral white matter linked to motor
pathways. ADC changes are negatively correlated with cognitive scores, which speak in favour of a possible myelination delay
already present at birth.