Electronic Posters: Neuroimaging - ismrm
Electronic Posters: Neuroimaging - ismrm
Electronic Posters: Neuroimaging - ismrm
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Tuesday 13:30-15:30 Computer 78<br />
13:30 4346. A Diffusion Tensor Imaging Study of Longitudinal White Matter Degeneration in<br />
Amyotrophic Lateral Sclerosis<br />
Yu Zhang 1,2 , Norbert Schuff 1,2 , Susan C. Woolley 3 , Gloria Chiang 1,2 , Lauren Boreta 1,2 ,<br />
Jonathan S. Katz 3 , Michael W. Weiner 1,2<br />
1 CIND VA Medical Center, San Francisco, CA, United States; 2 UC San Francisco, San Francisco, CA, United<br />
States; 3 Forbes Norris ALS Center, California Pacific Medical Center, San Francisco, CA, United States<br />
We report longitudinal differences of white matter degradation in 16 amyotrophic lateral sclerosis (ALS) patients who were scanned at<br />
7-month intervals, by using a preliminary longitudinal assessment of diffusion tensor MRI (DTI). Both tractography-guided ROI<br />
analysis and voxel-wise whole brain analysis showed a significant decline of fractional anisotropy (FA) over time in the right<br />
corticospinal tract (CST). Furthermore, the FA decline was significant in the localized (mild) subgroup of ALS but not the generalized<br />
(severe) subgroup. These preliminary results suggest that longitudinal DTI measurements capture clinical progression of ALS.<br />
14:00 4347. Correlation of Quantitative Diffusion Tensor Tractography with Clinical Grades of<br />
Subacute Sclerosing Panencephalitis<br />
Richa Trivedi 1 , H Anuradha 2 , Atul Agarwal 2 , Ram KS Rathore 3 , Kashi N. Prasad 4 ,<br />
Rajendra P. Tripathi 1 , Rakesh Kumar Gupta 5<br />
1 NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2 Neurology,<br />
Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 3 Mathematics and Statistics,<br />
Indian Institute of Technology, , Kanpur, Uttar Pradesh, India; 4 Microbiology, Sanjay Gandhi Post Graduate<br />
Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 5 Radiodiagnosis, Sanjay Gandhi Post Graduate<br />
Institute of Medical Sciences, Lucknow, Uttar Pradesh, India<br />
Diffusion tensor tractography using FACT algorithm was performed on 20 children with different grades of subacute sclerosing<br />
panencephalitis (SSPE) to look for probable correlation between tract-specific DTI metrics in major white matter pathways and<br />
Jabbour classification based clinical grades. A significant inverse correlation was observed between fractional anisotropy (FA) in<br />
major white matter tracts and clinical grades. We conclude that FA is a better measure than conventional MRI for the assessment of<br />
clinical grade in these patients.<br />
14:30 4348. Diffusion Tensor Imaging of Optic Neuritis and Its Recovery<br />
Nourhan Zayed 1 , Fiona Costello 2 , Michael Smith 3,4 , Bradley Goodyear, 23<br />
1 Electrical and Computer Engineering , University of Calgary, Calgary, Alberta, Canada; 2 Clinical<br />
Neurosciences, University of Calgary, Calgary, Alberta, Canada; 3 Electrical and Computer Engineering,<br />
University of Calgary, Calgary, Alberta, Canada; 4 Radiology, University of Calgary, Calgary, Alberta, Canada<br />
Appropriate DTI measures to characterize the presence and severity of optic neuritis (ON) as well as its recovery are not established.<br />
We hypothesized that the optic nerve experiencing ON may not actually exhibit significantly different FA or ADC from that of the<br />
unaffected eye or over the course of recovery. Instead, we predicted that ON is characterized by a greater distribution of FA and ADC,<br />
suggesting that acute ON is associated with more heterogeneous diffusion within the optic nerve. Variability of DTI measures, rather<br />
than means, may be a more sensitive indicator of the presence of ON and its recovery.<br />
15:00 4349. Effect of Central Nervous System Involvement in Systemic Lupus Erythematosus<br />
Patients : Examination Using Diffusion Parameters and Volumetric Measurement<br />
Shiou-Ping Lee 1 , Jie-Zhi Cheng 2 , Wen-Yang Chiang 3 , Chung-Ming Chen 2 , Kao-Lun<br />
Wang 1<br />
1 Department of Medical Imaging and Technology, Far Eastern Memorial Hospital, Taipei, Taiwan; 2 Institute of<br />
Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 3 Center for Optoelectronic Biomedicine,<br />
National Taiwan University Medical College, Taipei, Taiwan<br />
None of systemic lupus erythematosus (SLE) studies examined diffusion tensor imaging (DTI) and volumetric measurement in the<br />
same groups. This paper aimed to investigate the effect of central nervous system (CNS) involvement in SLE patients on two diffusion<br />
parameters, i.e., fractional anisotropy (FA) and mean diffusivity (MD), and one volumetric measurement, i.e., volume. To accurately<br />
define the corpus callosum boundaries, an automatic segmentation algorithm, cell-competition method, was adopted to delineate the<br />
boundaries of the corpus callosum on mid-sagittal FA maps to calculate FA, MD and volume of corpus callosum.<br />
Wednesday 13:30-15:30 Computer 78<br />
13:30 4350. In Vivo Vascular Hallmarks of Diffuse Leukoaraiosis<br />
Jinsoo Uh 1 , Uma Yezhuvath 1 , Yamei Cheng 1 , Hanzhang Lu 1<br />
1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United<br />
States<br />
We characterized multiple domains of vascular changes in leukoaraiosis using in vivo MR techniques. Compared to NAWM, CBF in<br />
leukoaraiosis regions was 38% lower (p=0.01) and CVR was 48% lower (p=0.005). Significant BBB leakage was also detected<br />
(p=0.04). Quantitative analysis revealed that the extent of BBB leakage was positively correlated with apparent diffusion coefficient.<br />
In addition, the total area of leukoaraiosis in the brain is correlated with the CVR in NAWM. This study shows that the vascular