Electronic Posters: Neuroimaging - ismrm

Advanced Imaging of Dementia & Neurodegenerative Disease, Part I
Hall B Monday 14:00-16:00 Computer 72
14:00 4242. BOLD Signal Fractal Dimension Mapping in AD Demonstrates Increase
Microvascular Activity and Metabolism When Combined with Spectroscopy
Mohammed Warsi 1 , D William Molloy 2 , Tim Standish 2 , Graeme Wardlaw 3 , Michael D.
Noseworthy 4
1 School of Biomedical Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; 2 Medicine,
St. Peters Hospital, Hamilton, Ontario, Canada; 3 Medical Physics and Applied Radiation Sciences, McMaster
University, Hamilton, Ontario, Canada; 4 Electrical and Computer Engineering, School of Biomedical
Engineering, McMaster University, Hamilton, Ontario, Canada
We present a BOLD signal fractal dimension (FD) mapping approach to assess the tissue microvascular environment in Alzheimer's
dementia. The periodicity or temporal complexity can be quantified using this method thus allow insight into the underlying
microvascular processes. Alzheimer’s Disease (AD) is associated with regional hypermicrovascularity, especially in the deep grey
matter. Furthermore our BOLD FD was inversely correlated to our MRS measures of total creatine.
14:30 4243. Automatic Segmentation of Hippocampal Subfields in T2-Weighted in Vivo MRI
Hongzhi Wang 1 , John B. Pluta 2 , Brian B. Avants 1 , Sandhitsu R. Das 1 , Caryne Craige 1 ,
Murat Altinay 1 , Michael W. Weiner 3 , Susanne Mueller 3 , Paul A. Yushkevich 1
1 Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2 Department of
Neurology, University of Pennsylvania, Philadelphia, PA, United States; 3 Center for Imaging of
Neurodegenerative Diseases, VA Medical Center, San Francisco, CA, United States
To be added
15:00 4244. A Diffusion Tensor Imaging Study of Cross-Sectional and Longitudinal White
Matter Alterations in Frontotemporal Lobar Degeneration
Yu Zhang 1,2 , Maria Carmela Tartaglia 2 , Norbert Schuff 1,2 , Gloria Chiang 1,2 , Christopher
Ching 1,2 , Howard J. Rosen 2 , Bruce L. Miller 2 , Michael W. Weiner 1,2
1 CIND VA Medical Center, San Francisco, CA, United States; 2 UC San Francisco, San Francisco, CA, United
States
Behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive nonfluent aphasia (PNFA) are three
major clinical subtypes of frontotemporal lobar degeneration (FTLD). In this study, cross-sectional and a preliminary longitudinal
diffusion tensor imaging (DTI) analyses were performed in 12 bvFTD, 6 SD, 6 PNFA, and 19 healthy control (CN) subjects. Crosssectional
analysis revealed bvFTD is associated with a characteristic pattern of fractional anisotropy (FA) reductions in the frontal and
temporal regions, SD predominantly affects the uncinate fasciculus, and PNFA affects the left arcuate fasciculus. Preliminary
longitudinal analysis suggests that DTI captures disease progression in FTLD.
15:30 4245. Automated Segmentation of Cortical and Subcortical Gray Matter Structures for
Evaluation of Alzheimer's Disease and Fronto-Temporal Dementia
Emil Malucelli 1 , David Neil Manners 1 , Claudia Testa 2 , Caterina Tonon 2 , Giovanni
Rizzo 2 , Roberto Poda 3 , Federico Oppi 3 , Michelangelo Stanzani Maserati 3 , Luisa
Sambati 3 , Bruno Barbiroli 2 , Roberto Gallassi 3 , Raffaele Lodi 2
1 Department of Internal Medicine, Aging and Nephrology , University of Bologna, Bologna, Italy; 2 Department
of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Italy; 3 Department of
Neurological Sciences, University of Bologna, Bologna, Italy
Objectives: To assess the ability of combined MR cortical structure volumetry and DTI to automatically detect regional brain changes
in patients with Alzheimer disease (AD) and Frontotemporal dementia (FTD). Methods: 9 AD patients, 7 FTD patients and 7 controls
were studied by 3D volumetric and DW MR imaging. An automated registration/segmentation pipeline defined cortical and
subcortical regions of interest, yielding structure volumes and mean diffusivity. Results. Diffuse volume reductions and MD increases
were found in both patient groups compared to controls. Conclusions: the protocol described has the potential to identify in vivo
surrogate markers for brain pathologic changes in neurodegeneration.
Tuesday 13:30-15:30 Computer 72
13:30 4246. DTI Measurements of Neurodegeneration in Early Alzheimer’s Disease: A Corpus
Callosum Study
Julio Acosta-Cabronero 1,2 , Guy B. Williams 1 , George Pengas 2 , Peter J. Nestor 2
1 Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom; 2 Neurology Unit, Department of Clinical Neurosciences, University of
Cambridge, Cambridge, Cambridgeshire, United Kingdom
The splenium and genu of the corpus callosum (CC), which contain millions of inter-hemispheric fibres, were found to be abnormal in
early AD. In this study, we analysed the behaviour of several DTI measures in the subregions of the midline CC and assessed their