Electronic Posters: Neuroimaging - ismrm

14:00 4431. Assessment of Cervical Venous Stenosis in Multiple Sclerosis Patients Using 4D
Flow MRI
Albert Hsiao 1 , Greg Zaharchuk 1 , Robert Herfkens 1 , Nancy J. Fischbein 1 , Marcus T.
Alley 1 , Michael Dake 2
1 Department of Radiology, Stanford University, Stanford, CA, United States; 2 Department of Cardiothoracic
Surgery, Stanford University, Stanford, CA, United States
Multiple sclerosis patients have unusual venous drainage patterns, which we have characterized using 4D velocity-encoded cine phase
contrast MRI.
14:30 4432. High Field in Vivo Magnetic Resonance Imaging of Lenticulostriate Arteries in
CADASIL
Michael K. Liem 1 , Saskia A.J. Lesnik Oberstein 2 , Maarten J. Versluis 1 , Joost Haan 3 ,
Andrew G. Webb 1 , Michel D. Ferrari 3 , Mark A. van Buchem 1 , Jeroen van der Grond 1
1 Radiology, Leiden University Medical Center, Leiden, Netherlands; 2 Clinical Genetics, Leiden University
Medical Center, Leiden, Netherlands; 3 Neurology, Leiden University Medical Center, Leiden, Netherlands
In this study we examined luminal diameters of lenticulostriate arteries in patients with cerebral autosomal dominant arteriopathy with
subcortical infarcts and leukoencephalopathy (CADASIL). Twenty-two CADASIL patients and 11 controls were examined using high
resolution 3D-time-of-flight magnetic resonance angiography (TOF MRA) imaging on a 7-Tesla MRI scanner. No differences
between CADASIL patients and controls were found in length, total number or total cross-sectional area of lenticulostriate artery
lumina. Measurements of lenticostriate arteries were not associated with lacunar infarct load in the basal ganglia area.
15:00 4433. Comparison Between 3D Phase Contrast MRI and Computational Fluid Dynamics
in Unruptured Intracranial Aneurysms.
Joppe Schneiders 1 , Pim van Ooij 2 , Joost van den Berg 1 , Ed van Bavel 2 , Aart J.
Nederveen 1 , Charles B. Majoie 1
1 Radiology, Academic Medical Center, Amsterdam, Netherlands; 2 Biomedical Engineering & Physics,
Academic Medical Center, Amsterdam, Netherlands
In this study we compare time averaged 4D MRI of intracranial aneurysms and surrounding vessels with simulations created using
Computational Fluid Dynamics(CFD). The vessel geometry is obtained from high resolution 3D rotational angiography and inflow
velocity is derived from 2D PC MR velocity measurements. We compared 4 patients with unruptured aneurysms, visualising the intraaneurysmal
flow pattern. With both modalities it is possible to visualise intra-aneurysmal flow patterns, with good agreement between
the two different techniques.
Thursday 13:30-15:30 Computer 83
13:30 4434. Global Pulse Wave Velocity in 87 Patients with Acute Ischemic Stroke and Aortic
Atherosclerosis
Andreas Harloff 1 , Wolf Wallis, Christoph Strecker, Stephanie Brendecke, Jan Simon,
Cornelius Weiller, Jürgen Hennig 2 , Michael Markl 2
1 Neurology, University Hospital Freiburg, Freiburg, Baden-Württemberg, Germany; 2 Diagnostic Radiology/MR
Physics
The aim was to evaluate the feasibility of a new method for estimating aortic pulse wave velocity (PWV) using flow-sensitive 4D
MRI. PWV was calculated by fitting a plane to all available data of the upslope portion of multiple flow waveforms along the entire
aorta. The value for the assessment of pulse wave velocity in the thoracic aorta was tested in 12 normal subjects and in 87 patients
with advanced aortic atherosclerosis. Analysis included a systematic evaluation of reproducibility, inter- and intra-observer variability.
Results indicate a relationship of the estimated compliance with age, aortic shape and the presence of disease.
14:00 4435. Flow Residence Time Predicts the Location of Intra-Aneurysmal Thrombus:
Numerical Modeling Based on MRA and MRV Data
Vitaliy L. Rayz 1 , Loic Boussel 2 , Liang Ge 3 , Joe R. Leach 1 , Alastair J. Martin 1 , Michael T.
Lawton 4 , David Saloner 1
1 Radiology, University of California San Francisco, San Francisco, CA, United States; 2 Creatis-LRMN (LB,
PCD), Lyon, France; 3 Surgery, University of California San Francisco; 4 Neurological Surgery, University of
California San Francisco
Thrombus deposition in cerebral aneurysms presents an increased risk of thrombo-embolism. The effect of increased flow residence
time (RT) on thrombus deposition was investigated using a new numerical flow visualization technique. MR angiography and MR
velocimetry data were used to construct patient-specific numerical models of the flow in three basilar aneurysms with known regions
of thrombus deposition. The flow RT maps computed with CFD in the base-line geometries were compared with intra-aneurysmal
regions that were observed to clot at the follow-up MRI studies. The results show that intra-aneurysmal regions with increased flow
residence time are prone to thrombus deposition.