Electronic Posters: Neuroimaging - ismrm

Multiple Sclerosis I
Hall B Monday 14:00-16:00 Computer 76
14:00 4310. Magnetization Transfer (MT) and Endogenous Chemical Exchange Saturation
Transfer (CEST) Effects in Patients with Clinically Isolated Syndrome
Ali Al-Radaideh 1 , Olivier Mougin 1 , Su-Yin Lim 2 , Christopher Tench 2 , Cris
Constantinescu 2 , Penny Gowland 1
1 Sir Peter Mansfield MR Centre, The University Of Nottingham, Nottingham, Nottinghamshire, United
Kingdom; 2 Clinical Neurology, The University Of Nottingham, Nottingham, Nottinghamshire, United Kingdom
Magnetization transfer (MT) is an important MRI measure in MS and the MT effect can be assessed qualitatively using magnetization
transfer ratio (MTR) maps.A distinctive peak is observed in the z -spectrum of the human brain, at -1.05k Hz offset from the water
frequency at 7T. This is caused by endogenous chemical exchange saturation transfer (CEST) between amide (chemical group
attached to the peptide bond) and water protons. Here we obtain MTR images for negative (MTR- sensitive to MT + CEST effects)
and positive (MTR+ sensitive to just MT effects) frequency offsets of the saturation and compare the distributions of these parameters
in NAWM of healthy controls and patients with Clinically Isolated Syndrome (CIS: a condition that is likely to lead to MS).
14:30 4311. Application of CEST Imaging to Study Amide Proton Transfer (APT) in Healthy
Controls and Multiple Sclerosis Pathology at 7 Tesla
Adrienne N. Dula 1,2 , Richard D. Dortch 1,2 , Bennett A. Landman 2,3 , Sid Pawate 4 , Patrick J.
Lavin 4 , Edward B. Welch, 1,5 , John C. Gore 1,2 , Seth A. Smith 1,2
1 Vanderbilt Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2 Radiology and
Radiological Sciences, Vanderbilt Medical Center, Nashville, TN, United States; 3 Electrical Engineering &
Computer Science, Vanderbilt University, Nashville, TN, United States; 4 Neurology, Vanderbilt Medical
Center, Nashville, TN, United States; 5 3MR Clinical Science, Philips Healthcare, Cleveland, OH, United States
Increased contrast from chemical exchange saturation transfer (CEST) effects in human brain at 7T has been used to study amide
proton transfer (APT) and applied in multiple sclerosis (MS). APT imaging is sensitive to the mobile protons associated with proteins
and peptides. The increased signal, T1, and spectral dispersion at 7T ameriorate this molecular MRI method. APT asymmetry analysis
at 7T was used to examine unique white matter, gray matter contrast in healthy controls as well as an MS patient. Herein, we utilize
the Water Spectrum Shift Reference (WASSR) method to correct for B0 inhomogeneities and center the CEST spectra.
15:00 4312. Multimodal High Resolution Magnetization Transfer and T1mapping in NAWM of
Patients with Clinically Isolated Syndrome
Ali Al-Radaideh 1 , Olivier Mougin 1 , Su-Yin Lim 2 , Christopher Tench 2 , Cris
Constantinescu 2 , Penny Gowland 1
1 Sir Peter Mansfield MR Centre, The University of Nottingham, Nottingham, Nottinghamshire, United
Kingdom; 2 Clinical Neurology, The University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
Multiple Sclerosis (MS) is known to reduce magnetization transfer ratio (MTR)and increase the longitudinal relaxation time (T1) in
the white matter (WM). Here, we measure the distribution of MTR and T1 values in normal appearing white matter (NAWM) at 7T
and high spatial resolution, comparing CIS patients with healthy controls.
15:30 4313. Magnetization Transfer Weighted Double Inversion Recovery for an Improved
Visualization of Neocortical and Juxtacortical Signal Abnormalities
Christian Langkammer 1 , Christian Enzinger 1 , Siegrid Fuchs 1 , Franz Fazekas 1 , Stefan
Ropele 1
1 Department of Neurology, Medical University of Graz, Graz, Austria
Signal abnormalities in multiple sclerosis such as neocortical and juxtacortical lesions can be visualized best using a double inversion
recovery (DIR) sequence. DIR sequences are based on T1 filtering and aim on suppressing signal from white matter and cerebrospinal
fluid. We here investigated, whether the application of additional MT saturation pulses can further improve the contrast between
cortex, white matter and embedded lesions. The new sequence was evaluated in the brain of healthy volunteers and multiple sclerosis
patients.
Tuesday 13:30-15:30 Computer 76
13:30 4314. Elimination of T 1 Weighting in FLAIR by Optimized Double IR – Could This Be the
Only T 2-Weighted Sequence Needed?
Ananth J. Madhuranthakam 1 , Subhendra N. Sarkar 2,3 , Reed F. Busse 4 , David C. Alsop 2,3
1 MR Applied Science Lab, GE Healthcare, Boston, MA, United States; 2 Radiology, Beth Israel Deaconess
Medical Center, Boston, MA, United States; 3 Harvard Medical School, Boston, MA, United States; 4 MR
Applied Science Lab, GE Healthcare, Madison, WI, United States
FLAIR is widely used for its improved conspicuity of long T2 lesions. However, concerns remain that the IR imparts T1 weighting
that can decrease detectability of some lesions. Frequently, both T2 and FLAIR are used in clinical protocols to guard against these
concerns. Recently, double IR (DIR) has been proposed to highlight some brain lesions by nulling both WM and CSF but produces