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McKERRACHER, LisaMcKERRACHER, LisaTél. (514) 282-9990 Pathologie et biologie cellulaire(514) 343-6111 ext. 1472 Université de MontréalC.P. 6128, Succ. Centre-ville, Montréal (Québec)Fax (514) 343-5755 Canada H3C 3J7URL site WWW: http://www.bioaxone.com/labumontreal/LabindexFr.htmlE-Mail: lisa.mckerracher@umontreal.caURL personnel CV:Statut universitaire / University statusProfesseure titulairePathologie et biologie cellulaireFaculté de médecineUniversité de MontréalAppartenance à d'autres groupes / Affiliation with other groupsDepartment of Neurology & Neurosurgery, McGill UniversityBioAxone Therapeutic Inc., Chief Scientific OfficerMembre du Centre de recherche en sciences neurologiques (CRSN)Formation / TrainingB.Sc., Université McGill, Biologie, 1981Ph.D., York University, Toronto, Biologie, 1986Stage postdoctoral, Worcester Found. For Experimental Biology, Shrewsbury, MA, 1986-1987Stage postdoctoral, Ctre de recherche en sciences neurologiques, Université McGill, 1987-1990Orientation de la recherchePrincipaux projets en cours:••Research orientation•Nerve regeneration in the central nervous system•Growth core motility and axonal guidance•Growth inhibitory moleculesCurrent research projects:••Publications choisies/Selected publicationsLehmann, M., Fournier, A., Selles-Navarro, I., Dergham, P., Sebok, A., Leclerc, N., Tigyi, G., McKerracher, L. Inactivation of Rho signalingpathway promotes CNS axons regeneration. J. Neurosci., 19 :7537-7547, 1999.Huang,D-W., McKerracher,L., Braun, PE., David, S. A therapeutic vaccine approach to stimulate regeneration in the adult mammalian spinalcord. Neuron 24 :639-647, 1999.Ellezam, B., Selléés-Navarro, I., Manitt, C., Kennedy, T., McKerracher, L. Expression of netrin-1 and its receptors DCC and Unc5H2 afteraxotomy and during regeneration of adult rat retinal ganglion cells.. Exp. Neurol. 168:105-115, 2001.Dergham, P., Ellezam, B. Essagian, C., Avedissian, H., Lubell, W.D., McKerracher, L. Rho Signaling Pathway Targeted to Promote SpinalCord Repair. J. Neuroscience, 22:6570-6577, 2002.Winton,M., Dubreuil, C.I., Lasko, D., Leclerc,N., McKerracher,L. Inactivation of Rho by new cell permeable C3-like proteins stimulatesneurite outgrowth on inhibitory substrates. J. Biol. Chem. 277:32820-32829, 2002.McKerracher, L. Ganglioside rafts as MAG receptors that mediate blockade of axon growth. Proc. Natl. Acad. Sci. 99:78-11-7813, 2002.McKerracher, L and Ellezam, B. Putting the brakes on regeneration. Science 296: 1819-1020, 2002.McKerracher, L. and Winton, M.J. Nogo on the go. Neuron. 36:345-348, 2002.Dubreuil, C.I. Winton, M. McKerracher,L. Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in theCNS. J. Cell Biology 162:233-243, 2003.Page 43