BULETINUL ИЗВЕСТИЯ JOURNAL

Buletinul AŞM. Ştiinţele vieţii. Nr. 3(318) 2012
Fiziologia şi Samocreatologia
double bond distance (1.615 Å), it could be concluded that in the solid state this
thiosemicarbazide is more likely to adopt the thio-ketone form (Figure 1).
Moreover, as the 4 NH–C(S) bond has a s-trans conformation, the thiosemicarbazide
rest NHC(S) NHNH 2 gets out of the plane of 2,4-dimethylphenyl ring and causes steric
hindrances in the crystal packing (Figure 2).
Figure 1. Molecular
structure of N-(2,4dimethylphenyl)hydrazinecarbothioamide
Figure 2. Crystal packing of N-(2,4-dimethylphenyl)hydrazinecarbothioamide
Conclusions
N-(2,4-dimethylphenyl) hydrazinecarbothioamide and its fi ve azomethine derivatives
have been synthesized starting from commercially available 2,4-dimethylaniline.
The composition and the structure of the synthesized compounds have been defi ned by
means of 1 H, 13 C NMR and X-ray diffraction. Antileukaemia bioassays have shown that
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