Vitalstoffe – Das Magazin für Mikronährstoffe und deren Wirkungen
Vitalstoffe – Das Magazin für Mikronährstoffe und deren Wirkungen
Vitalstoffe – Das Magazin für Mikronährstoffe und deren Wirkungen
Erfolgreiche ePaper selbst erstellen
Machen Sie aus Ihren PDF Publikationen ein blätterbares Flipbook mit unserer einzigartigen Google optimierten e-Paper Software.
V italstoffe<br />
48<br />
Momordica charantia kann als Gemüse<br />
wie auch als Zubereitung zur Nahrungsergänzung,<br />
metabolische Vorgänge innerhalb<br />
des Kohlenhydratstoffwechsels<br />
ernährungsphysiologisch unterstützen.<br />
Die Bittermelone eine interessante Option<br />
zur Prävention von diabetogenen<br />
Risikopatienten zu sein, die z.B. an<br />
Übergewicht leiden <strong>und</strong> die Medikamente<br />
anwenden, die die Glucosetoleranz<br />
beeinflussen. Die Forschungsarbeiten,<br />
Literatur:<br />
neue effektivere Bittermelonensorten<br />
zu testen bzw. zu züchten, werden von<br />
der Beratungsgruppe <strong>für</strong> entwicklungsorientierte<br />
Agrarforschung (BEAF) der<br />
Deutschen Gesellschaft <strong>für</strong> Technische<br />
Zusammenarbeit (GTZ) im Auftrag des<br />
B<strong>und</strong>esministeriums <strong>für</strong> wirtschaftliche<br />
Zusammenarbeit <strong>und</strong> Entwicklung gefördert.<br />
Es ist zu hoffen, dass die Studienergebnisse<br />
eine neue Basis <strong>für</strong> neue<br />
Therapieoptionen darstellt.<br />
Autor:<br />
Jens Bielenberg<br />
Apotheker<br />
Raphael-Apotheke<br />
25364 Westerhorn<br />
1 Tsai, CH; Chen, ECF; Tsay, HS; Huang, CJ. Wild bitter gourd improves metabolic syndrome:A preliminary dietary supplementation trial.<br />
Nutr J 2012 11:4.Published online 2012,Jan.13 .10.1186/1475-2891-11-4<br />
2 Chen, Q; Chan, LL.; Li, ET: Bitter Melon (Momordica charantia) reduces adiposity , lowers serum insulin and normalizes glucose tolerance in<br />
rats fed a high fat diet. J Nutr. 2003; 133(4):1088-93<br />
3 Matsuda, H.; Li, Y.; Murakami, T.et al Antidiabetic principles of natural medicines III. Structure related inhibitory activity and action mode of<br />
oleanic acid glycosides on hypoglycemic activity. Chem Pharm Bull (Tokyo) 1998;46:399-403<br />
4 Rathi,SS.; Grover, JK.; Vats, V. The effect of Momordica charantia and mucuna pruriens in experimental diabetis and their effect on key<br />
metabolic enzymes involved in carbohydrate metabolism. Phytother Res. 2002; 16(3):236-43<br />
5 Ahmed, I; Adeghate, E; Sharma, AK; Pallot, DJ; Singh,J. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of<br />
stretozotocin- diabetic rat. Diabetes Research and Clinical Practise 1998;40:145-51<br />
6 Day,C.; Cartwright, T.; Provost, J.; Bailey,CJ. Hypoglycaemic effect of Momordica charantia extracts. Planta Med 1990;56: 426-9<br />
7 Miura, T.; Itoh, C.; Iwamoto, N.; Kato,M.; Kawai, M. Hypoglycemic Activity of the fruit of the Momordica charantia in Type 2 diabetic mice.<br />
J Nutr Sci Vitaminol 2001;47:340-44<br />
8 Grover,JK.;Yadaf, SP. Pharmacological actions and potential uses of Momordica charantia: a review J Ethnopharmacol 2004 Jul; 93(1):123-32<br />
9 Chaturved,i P. Antidiabetic potentials of Momordica charantia :multiple mechanisms behind the effects. J Med Food 2012 Feb;15(2):101-7.<br />
Epub 2011<br />
10 Neuwinger, HD. Afrikanische Arzneipflanzen <strong>und</strong> Jagdgifte Wissenschaftliche Verlagsgesellschaft mbH Stuttgart 2.Auflage 1998 S.404-6<br />
11 R ivera, G. Preliminary chemical and pharmacological studies on c<strong>und</strong>eamor,Momordica charantia L. Americ.J. Pharm. 1942; 114:72-87<br />
12 Khanna, P; Pangaria, SC; Dixit,VP. Hypoglycaemic activity of polypeptide P from plant sourc J.Nat. Prod. 1981;44: 648-55<br />
13 Sreejayan, M.N.A.,Rao. Oxygen free radical scavenging activity of the juice of Momordica charantia fruits Fitotherapia 1991,344-6<br />
14 Chen, Q; Chan,LL; Li ET; Bitter melon ( Momordica charantia) reduces adiposity,lowers serum insulin and normalizes glucose tolerance in<br />
rats fed a high fat diet. J Nutr 2003;133(4):1088-93<br />
15 Blum, A; Loerz, C; Martin, HJ; Staab-Weijnitz, CA; Maser; E. Momordica charantia extract , a herbal remedy for type 2 diabetes, contains a<br />
specific 11ß-hydroxysteroid dehydrogenase type 1 inhibitor. J of Steroid Biochemistry and Molecular Biology.2012; 128:51-55.<br />
16 Rivera, G. Preliminary chemical and pharmacological studies on c<strong>und</strong>eamor,Momordica charantia L. Americ.J. Pharm. 1942; 114:72-87<br />
17 Khanna, P.; Pangaria, S.C.; Dixit,V.P. Hypoglycaemic activity of polypeptide P from plant source J.Nat. Prod. 1981;44: 648-55<br />
18 Chen, Q.;Chan LL.; Li ET: Bitter Melon (Momordica charantia) reduces adiposity , lowers serum insulin and normalizes glucose tolerance in<br />
rats fed a high fat diet J Nutr. 2003; 133(4):1088-93<br />
19 Senanayake, GV.; Maruyama,M.; Shibuya,K.; Sakano,M.;Morishita,T.; Yukizaki,C.; Kawano,M; Ohta,H. The effects of bitter melon (Momordica<br />
charantia) on serum and liver triglyceride levels in rats. J Ethnopharmacol 2004 Apr; 91(2-3):257-62 20 Tsai, CH; Chen, ECF; Tsay, HS; Huang,<br />
CJ. Wild bitter gourd improves metabolic syndrome:A preliminary dietary supplementation trial. Nutr J 2012 11:4.Published online 2012,<br />
Jan.13 .10.1186/1475-2891-11-4<br />
21 Zänker, KS; Mang, B; Wolters, M; Hahn, A. Personalized Diabetes and Cancer Medicine :A Rationale for anti-diabetic Nutrition (Bitter Lemon)<br />
in a supportive setting. Current Cancer Therapy Reviews. 2012; 8:66-77<br />
22 Wang, Z; Wang, RM.; Owji, AA. Glucagon-like peptide-1 is a physiological incretin in rat. J Clin Invest 1995;95:417-21 Iovino, A; Scheen,<br />
A. Modulation of tissue exposure to cortisol. A new perspective for reducing the metabolic risk associated with obesity. Rev Med Liege 2010;<br />
65(3):140-6<br />
23 Wang, M. Inhibitors of 11ß-hydroxysteroiddehydrogenase type1 in antidiabetic therapy. Handb Exp Pharmacol 2011;203:127-46<br />
24 Dhanesha N; Joharapurkar, A; Shah, G; et al. Inhibition of 11ß-Hydroxysteroid dehydrogenase 1 by carbenoxolone affects glucose homeostasis<br />
and obesity in db/db mice. Clin Exp. Pharmacol Physiol 2012,39(1):69-77.<br />
25 Boyle, CD; Kowalski, TJ. 11ß-hydroxysteroiddehydrogenase type1 inhibitors: a review of recent patents<br />
Expert Opin Ther Pat 2009 ;19(6):801-25<br />
26 Singh, S; Tice, C. Structure based design of 11ß HSD1 inhibitors. Curr Pharm Biotechnol.2010 Nov.;11(7):779-91<br />
27 Jamieson; PM; Walker, BR; Chapmen; KE; Andrew, R; Rossiter, S; Seckl, JR. 11-ß-Hydroxysteroiddehydrogenase type 1 is a predominant 11-ß-<br />
Reduktase in the intact perfused rat liver. J Endocrinol 2000; 3: 685-693.<br />
28 Chen, Q; Chan,LL; Li ET; Bitter melon ( Momordica charantia) reduces adiposity,lowers serum insulin and normalizes glucose tolerance in<br />
rats fed a high fat diet. J Nutr 2003;133(4):1088-93<br />
29 Leatherdale, BA.; Panesar, RK.; Singh,G; Improvement in glucose tolerance due to Momordica charantia (karela) Br Med J.1981;282:1823-4<br />
30 Zänker, K.; Gottschalk, G.; Hans, S. Sicherheits- <strong>und</strong> Wirksamkeitsstudie mit einem Extrakt aus Momordica charantia bei Patienten mit Typ-<br />
2-Diabetes Zeitschrift <strong>für</strong> Phytotherapie 2003; 24:163-9<br />
31 Prinz, S.; Kopp, B. Momordica charantia Österreichische Apothekerzeitung 2004, 3:1-10<br />
32 Chan, W.; Tam, PP.; Yeung, HW. Contraception 1984, 29(1):91-100<br />
33 Nerurkar, P; Ray,RB. Bitter Melon :antagonist to cancer. Pharm Res 2010; 27(6):1049-53<br />
34 Agarwal, RC; Beohar Tripti. Chemopreventive and anticarcinogetic effects of Momordica charantia extract. Asian Pacific Journal of cancer<br />
Prevention.;2010; 11: 371-75<br />
35 Tan MJ et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway.<br />
Chem Biol 2008,15(3):263-73