FORMAL COMPLAINT - Sweden Confidential

United Nations petition — incomplete report
attributable to perphenazine/Trilafon/Fentazine, as I believe this may be of
common interest and value —
Firstly perphenazine will overturn and largely invalidate the endogenous pro-
duction, chemical properties and natural distribution etc of several catechol-
amines chiefly generated by hydroxylation of the L-isomeric amino acid
tyrosine* (*cf tyrosinase → cathecol oxidase).
The 3,4-dihydroxyphenylalanine* (*DOPA) formed by the tyrosine hydroxylase
is the biosynthetic precursor of the essential cathecholamines dopamine* (*[3,4-
dihydroxyphenyl]ethyl amine), noradrenaline* (*norepinephrine) and
adrenaline* (*epinephrine).
The cathecolamines serves and triggers an impressive number specialized
physiological and neurochemical etc functions and actions impeded by the
toxicological impact of perphenazine; vital mechanisms regulating e.g blood
pressure, heart rate, breathing, metabolism and muscle tone are temporary or
permanently corrupted/destroyed. Dangerously interfering with the hydroxy-
lation of phenylalanine to tyrosine and subsequent dihydropteridine reductase,
the transamination of tyrosine to p-hydroxyphenylpyruvate and concurrent
reaction with O2 to form homogentisate is significantly incapacitated, thus
provoking detrimental accumulation of the nerve poison phenylpyruvic acid in
the body fluids as well as in varietal tissues where it evades most drug
monitoring and toxicological screening procedures usw. Exerting a generally
cytopathogenic effect, perphenazine obstructs the natural interaction between
various nitrogenase and reductase agents, and consequently upset the entire
nitrogen
equilibrium/metabolism; hydrolysis of ATP* (*adenosine triphosphate) and
hepatic amino acid degradation is incapacitated, and the constructive functions
of v.g the enzymes alanine/aspartate aminotransferase and glutamate dehydro-
genase perilously hampered.
Whereas practically all fundamental properties of cells are products of molecular
interactions between their respective nucleic acids and proteins, the metabolically
decisive amounts of the adenine nucleotides ATP/ADP/AMP is relatively
disproportionated by the principally cytoclastic influence waged by perphenazine
— ATPs phosphoryl transfer potential is diminished, and efficient hydro-
lysis of phosphocreatine obstructed.
Adenosine triphosphate is the universal main carrier of all forms of chemical
energy in living organisms — as it transfer energy to other molecules, ATP loses
its terminal phosphate group as inorganic phosphate* (*orthophosphate, Pi), or
two of its phosphate groups as inorganic pyrophosphate* (*PPi), becoming
adenosine diphosphate* (*ADP) or adenosine monophosphate* (*AMP), respectively.
Described hydroxylation of ATP to ADP/Pi and AMP/PPi relies on the catalytic
purveyance of the enzymes hexokinase* (*catalyzing the phosporylation of glu-
90
FORMAL COMPLAINT VS THE KINGDOM OF NORWAY
by Wilh. Werner WINTHER, Norway
90