FORMAL COMPLAINT - Sweden Confidential

United Nations petition — incomplete report
As regards peptide hormones, catecholamines and receptors of the G-protein
class utilizing guanine nucleotide-binding proteins to interface with target
proteins (e.g phospholipase C), perphenazine makes it knotty for corresponding
ligand hormone to bind to the actual receptor protein thus activating the adeny-
late cyclase through the guanine nucleotide regulatory protein binding guanosine
triphosphate* (*GTP).
Generally impairing the GTPase activity in regulatory protein and thus damaging
the 21-kd ras proteins cycling between GTP and GDP* (*guanosine di-
phosphate) forms, perphenazine will corrupt the GTP form of these proteins
(stimulating cell growth and differentiation) item the 120-kd integral membrane
protein and adjacent transmembrane segments of adenylate cyclase and,
resultantly, significantly increase the cancer risk.
The formation and further hydrolyzation of cyclic adenosine monophosphate*
(*cAMP) to 5‘-AMP by a specific phosphodiesterase is hindered by perphenazine,
as the activation of adenylate cyclase converting ATP to cAMP and the
normal 3‘-OH group of the ribose unit attacking the α-phosphoryl group of
ATP to form a phosphate bound with the concomitant release of pyrophosphate
has been greatly and negatively upset by the unilaterally injurious effects of this
politically abused and virose downer.
Cyclic adenosine monophosphate is supposed to bind to the regulatory subunit
of protein kinase thus dissociating the catalytic subunit vitally responsible for
the phosphorylation of a wide spectrum enzymes and other proteins, and it enhances
the degradation of storage fuels, increases the secretion of acid by the
gastric mucosa, leads to the dispersion of melanin pigment granules, diminishes
the aggregation of blood platelets and induces the opening of chloride channels
etc.
All enzymes are believed to be synthesized intracellularly, and most of them
certainly carry out their functions within the cells in which they are formed....
anyhow; many of those enzymes later finding their way into the blood or otherwise
exerting their functions within extracellular fluids, will have the better part
of their constructive properties devastated by perphenazine — the catalytic ope-
rativeness of the proteases and other hydrolases (secreted into the gastrointestinal
tract) item the plasma-specific enzymes* (*enzymes concerned e.g with
fibrinolysis and the functionality of the blood-clotting mechanism and comple-
ment system) are dramatically suppressed.....this may — amongst dozens of
other complications — catastrophically lower the general immune response, and
lead to partial/complete and potentially fatal paralysis of certain viscerimotor/
splanchnic nerves.
The list of metabolic disturbances and overall pathogenicity linked to perphenazine
intake is almost endless; all catabolic pathways of the branched-chain amino
acids* (*leucine, isoleucine and valine) are devitalized, and the natural out-
94
FORMAL COMPLAINT VS THE KINGDOM OF NORWAY
by Wilh. Werner WINTHER, Norway
94