FORMAL COMPLAINT - Sweden Confidential

United Nations petition — incomplete report
put and properties of e.g oxidative decarboxylase, valine transaminase and iso-
valeryl-CoA-dehydrogenase corrupted — there‘ll be sulfur amino acids disorders,
and pathological alterations of the imino acid metabolism.....convenient
conversion of methionine to homocysteine is sapped, and crucial functions of
cystathionine synthease, serine, proline oxidase and pyrroline-5-carboxylic acid
dehydrogenase vehemently perverted.
Perphenazine will perilously inhibit the thermal transition of ribonuclease, and
the conformational transition of α-lactalbumin is either slowed down or comple-
tely barred — the formation of molten globules is constrained, and the hydrogen
bond donor of serine, aspartate and asparagine is frequently harmed (natural dis-
ruption of α-helicles is thereby obstructed).....basically; the stabilization of
intermediates necessary for unimpaired protein folding is crippled.
In the Krebs-Hensleit cycle* (*i.e the urea cycle) the intermediate properties of
citrulline, arginine, ornitrine and arginiosuccinic acid are strongly reduced by
perphenazine, and the ominous presence of this psychotogenic nosotoxicant will
induce multiform, systemic irregularities of the amino acid metabolism —
we‘ll find several substrate-specific defects, and there‘ll be grave histidine,
lysine and glycine metabolism abnormalities.
Perversion of the proline oxidase and lysine/glycine metabolism etc will deplete
the vital/steric repulsion of the pyrrolidone rings found in the proline/hydroxy-
proline residues of the collagen helix (collagen — the most abundant protein in
man/mammals — has no hydrogen bonds within its triple helix strands, hence
the stability of the three collagen helicles depends on indicated repulsion...anyhow;
because there‘s no space near the helix axis for a larger amino acid, every
third residue of its superhelical cable must be glycine, and the three intertwined
strands of corresponding superhelix are bonded to each other by — hydrogen.),
and described suppression of v.g the proteases/hydrolases etc will detrimentally
affect the functions of three major digestive enzymes — viz; chymotrypsin
(hydrolyzing proteins in the small intestine), trypsin and pepsin — the enzyme/
zymogen synthesizing in the acinar cells of the pancreas is sabotaged.
The extracellular protein collagen is commonly known as the main fibrous com-
ponent of the skin, bone, teeth, cartilage and tendon, and attingent gutting of its
primary/secondary/tertiary/quaternary structure etc by perphenazine is associated
with a very extensive range disagreeable implications; the conversion of
many lysine side chains to aldehydes and the further combination of said aldehydes
with the ε-amino groups of intact lysine chains is recurrently diverted, and
the degradation of cross-linked collagen/elastin and subsequent formation of
(iso-)desmosins from cross-linked lysine fragments menacingly vacillated —
there‘ll be disturbances of the water/electrolyte balance, acid–base imbalances,
a most distressing variety of e.g cardiovascular/liver/biliary tract/renal/splenetic/
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FORMAL COMPLAINT VS THE KINGDOM OF NORWAY
by Wilh. Werner WINTHER, Norway
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