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Ganong's Review of Medical Physiology, 23rd Edition

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180 SECTION III Central & Peripheral Neurophysiology<br />

4. A 50-year-old woman undergoes a neurological exam that indicates<br />

loss <strong>of</strong> pain and temperature sensitivity, vibratory sense,<br />

and proprioception in both legs. These symptoms could be<br />

explained by<br />

A) a tumor on the medial lemniscal pathway in the sacral spinal<br />

cord.<br />

B) a peripheral neuropathy.<br />

C) a large tumor in the sacral dorsal horn.<br />

D) a large tumor affecting the posterior paracentral gyri.<br />

E) a large tumor in the ventral posterolateral and posteromedial<br />

thalamic nuclei.<br />

CHAPTER RESOURCES<br />

Baron R, Maier C: Phantom limb pain: Are cutaneous nociceptors<br />

and spinothalamic neurons involved in the signaling and<br />

maintenance <strong>of</strong> spontaneous and touch-evoked pain? A case<br />

report. Pain 1995;60:223.<br />

Blumenfeld H: Neuroanatomy Through Clinical Cases. Sinauer<br />

Associates, 2002.<br />

Haines DE (editor): Fundamental Neuroscience for Basic and Clinical<br />

Applications, 3rd ed. Elsevier, 2006.<br />

Herman J: Phantom limb: From medical knowledge to folk wisdom<br />

and back. Ann Int Med 1998;128:76.<br />

Hopkins K: Show me where it hurts: Tracing the pathways <strong>of</strong> pain. J<br />

NIH Res 1997;9:37.<br />

Kandel ER, Schwartz JH, Jessell TM (editors): Principles <strong>of</strong> Neural<br />

Science, 4th ed. McGraw-Hill, 2000.<br />

Melzack R: The tragedy <strong>of</strong> needless pain. Sci Am 1991;262:27.<br />

Penfield W, Rasmussen T: The Cerebral Cortex <strong>of</strong> Man: A Clinical<br />

Study <strong>of</strong> Localization <strong>of</strong> Function. Macmillan, 1950.<br />

Willis WD: The somatosensory system, with emphasis on structures<br />

important for pain. Brain Res Rev 2007;55:297.

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