View Annual Report - Jules Stein Eye Institute

Corneal Endothelial Cell Changes
in Children with Uveitis
This is a prospective study to evaluate
the cornea, specifically endothelial
cells, in children with uveitis. Uveitis is
a general term meaning inflammation
inside the eye. Investigators will be
comparing these changes for children
with anterior uveitis who have received
a glaucoma drainage tube and those
who have not. Investigators: Gary N.
Holland, MD; Joseph Caprioli, MD;
JoAnn Giaconi, MD; Simon K. Law, MD,
PharmD; and Ralph D. Levinson, MD
A Comprehensive Analysis of
Visual Function in Patients
Diagnosed with Birdshot
Chorioretinopathy
The main goal in this study is to investigate
the relationship between vision
dysfunction (eg, symptoms, visual
field changes, contrast sensitivity, and
color vision changes) experienced
by patients diagnosed with birdshot
chorioretinopathy and the location
of defects in the retina as identified
by electrophysiological testing.
Investigators: Gary N. Holland, MD;
Ralph D. Levinson, MD; and Steven
Nusinowitz, PhD
General Ophthalmology
Clinical Testing of the Tracking
Adaptive Scanning Laser
Ophthalmoscope (TASLO)
This clinical study evaluates the
capabilities of the TASLO in eye health
and disease. This may lead to earlier
detection of eye disease and a better
understanding of anatomy and abnormal
conditions of the eye. Investigators:
Kevin M. Miller, MD; Michael B.
Gorin, MD, PhD; and Michael B. Olson,
OD, PhD
Glaucoma and Optic Nerve
Clinical Measurements of the
Optic Nerve in Glaucoma
The goal of this study is to develop
novel structural measures of the optic
nerve and nerve fiber layer, which are
sensitive and specific for early and
progressive glaucomatous optic nerve
damage. Investigators: Joseph Caprioli,
MD; Anne L. Coleman, MD, PhD; and
Simon K. Law, MD, PharmD
Earlier Intraocular Pressure
Control after Ahmed Glaucoma
Valve Implantation
The purpose of this study is to evaluate
the occurrence rate of the high
pressure phase and the final pressure
outcomes between subjects treated
with glaucoma medications prior to the
onset of the high pressure phase and
subjects who start glaucoma medications
at the onset of the high pressure
phase. Investigators: Simon K. Law,
MD, PharmD; Joseph Caprioli, MD;
Anne L. Coleman, MD, PhD; and JoAnn
Giaconi, MD
Effect of Yoga on Glaucoma
The purpose of this study is to examine
the practice of yoga and its ability to
improve a patient’s vision by relieving
stress and reducing eye pressure.
Investigator: Anne L. Coleman,
MD, PhD
Glaucoma Drainage Devices
and Filtering Surgery
with Antimetabolites
This study looks at the effect of
two surgical procedures—glaucoma
implant surgery and filtering surgery
with antimetabolites—on the corneal
endothelium. It evaluates the possibility
of surgical damage to the corneal
endothelium, which may result in loss
of corneal clarity. Investigators: Anne
L. Coleman, MD, PhD; Joseph Caprioli,
MD; JoAnn Giaconi, MD; and Simon K.
Law, MD, PharmD
Glaucomatous Cupping and
Visual Field Abnormalities in
Chinese Young Adults
The glaucoma-like syndrome is a condition
where patients appear to have
signs of glaucoma but are actually
normal. This glaucoma-like syndrome
is unusually common in young adult
Chinese patients who normally would
not be expected to show signs of eye
disease. The purpose of the study is to
determine the prevalence and characteristics
of the glaucoma-like syndrome
in Chinese young adults. Investigator:
Simon K. Law, MD, PharmD
Ocular Hypertension
Treatment Study
Since topical hypotensive medications
are safe and effective in delaying or
preventing primary open angle glaucoma,
this study is examining whether
other forms of treatment can be
deferred with little or no penalty. Investigator:
Anne L. Coleman, MD, PhD
Optic Nerve Appearance
in Age-Related
Macular Degeneration
In order to evaluate the relationship
between macular degeneration and
optic nerve change, digital imaging
technology and photography are being
used to assess the structural appearance
of the optic nerve in patients
with age-related macular degeneration.
Investigator: Simon K. Law,
MD, PharmD
Vision-Related Quality of Life and
Ocular Dominance
This study is designed to evaluate how
quality of life is impacted by glaucoma
in relation to eye dominance. It aims
to determine whether quality of life is
affected more by glaucoma if it primarily
affects the dominant eye. Investigators:
Simon K. Law, MD, PharmD;
Joseph Caprioli, MD; Anne L. Coleman,
MD, PhD; and JoAnn Giaconi, MD
Appendices | Clinical Research Studies 107