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PET/CT Imaging for Early Detection of Ocular Melanoma This research involves the use of combined positron emission tomography (PET)/computed tomography (CT) scans in subjects with ocular melanoma. It may ultimately provide new knowledge that will be used to develop better ways of monitoring for tumor spread and allow for early treatment if metastasis is found. Investigators: Tara A. McCannel, MD, PhD; and Bradley R. Straatsma, MD, JD Orbital and Ophthalmic Plastic Surgery Volumetric Analysis of Orbital Images (CT and MRI Sequences) with Mimics Image Processing Software This study is evaluating the volumetric changes of orbital tissues using a validated 3D image processing software. Orbital diseases such as thyroid eye disease, myositis, inflammatory and neoplastic conditions are characterized by significant soft tissue changes. Their assessment with Mimics software is helpful in understanding the clinical course of these diseases, as well as defining the etiologic and pathogenetic mechanisms involved. Investigator: Robert A. Goldberg, MD Ultrasound Study of Eyelid Mobility Before and After Blepharoplasty and Injectable Fillers This study uses a high-resolution ultrasound machine to capture realtime films of the tissues immediately surrounding the eye. Patients in each of the following three arms are being studied: pre/post botulinum toxin injection, pre/post synthetic filler injection, and pre/post periocular cosmetic surgery, including fat repositioning or fat transfer. Data gathered is being used to study the dispersion of filler injections, to gain more detailed and accurate insight into this cosmetic field. Investigator: Robert A. Goldberg, MD Studies on Tissue in Autoimmune Diseases This study aims to determine the cause of eye problems in Graves disease and other autoimmune diseases. Examination is being done of material removed from orbits during surgical therapy for Graves disease or other problems requiring surgery on the tissue surrounding the eyes; of thyroid tissue removed during the course of surgical therapy; or of blood drawn for laboratory tests. Investigator: Robert A. Goldberg, MD Quality of Life Study in Patients with Graves Disease This study is assessing the quality of life in patients with Graves disease orbitopathy before and after medical treatment or medical procedures. Investigator: Robert A. Goldberg, MD Pediatrics and Strabismus Biomechanical Analysis in Strabismus Surgery This study aims to develop new diagnostic tests and computer models that will lead to improvements in strabismus surgery. Tests of binocular alignment and eye movements, as well as magnetic resonance imaging of the extraocular muscles, are being performed in the Institute’s Clinical and Basic Science Ocular Motility Laboratory before and after strabismus surgery. To date, this research has fundamentally contributed to the knowledge of the functional anatomy of the extraocular muscles and connective tissues, and allowed discovery of causes of common strabismus and development of new types of surgeries. Investigator: Joseph L. Demer, MD, PhD Contact Lens Study The purpose of this study is to identify rates of complications and correlations to modality of wear, care system, hygiene, or other factors associated with contact lens complications. Investigators: Vivian Phan, OD; Sharon Y. Lee, OD; Bartly J. Mondino, MD; and Barry A. Weissman, OD, PhD Genetic and Anatomic Studies of Eye Movement Disorders This collaborative National Eye Institute-funded study is conducting magnetic resonance imaging of the extraocular muscles. This procedure clarifies the phenotypes and mechanisms of congenital cranial dysinnervation syndromes whose hereditary properties have been characterized using modern molecular genetics. Patients with these syndromes have severe forms of strabismus. Investigator: Joseph L. Demer, MD, PhD Optic Nerve in Amblyopia Amblyopia is a major cause of childhood visual loss. This study uses high resolution, surface-coil magnetic resonance imaging to study optic nerve size in amblyopia. It tests the theory that the optic nerve is smaller than normal in amblyopia and that optic nerve size may be a limiting factor in restoration of vision by amblyopia treatment. Investigator: Joseph L. Demer, MD, PhD A Randomized Clinical Trial of Observation Versus Occlusion Therapy for Intermittent Exotropia Although occlusion treatment, or patching of the eye, is a widely used treatment for intermittent exotropia (IXT), there have been no randomized clinical trials evaluating its effectiveness. This study is being conducted to assess the natural history of IXT and to establish the effectiveness of patching in its treatment. Investigators: Stacey L. Pineles, MD; and Federico G. Velez, MD Appendices | Clinical Research Studies 111
Sweep Visual Evoked Potential for Use in Amblyopia and Pediatric Optic Nerve Disorders Using a new technique, investigators are measuring vision in preverbal children to diagnose and follow optic nerve diseases. Currently, treatment decisions are based on clinical examinations that are insensitive and reveal vision loss well after permanent damage has taken place. This technique allows more accurate examinations, leading to provision of treatments at the first signs of vision loss, thereby decreasing the risk of permanent damage. Investigators: Stacey L. Pineles, MD; Joseph L. Demer, MD, PhD; Sherwin Isenberg, MD; and Federico G. Velez, MD Prospective Study to Determine the Proportion of Patients with Isolated Third, Fourth, and Sixth Nerve Palsies of Microvascular Versus Nonmicrovascular Etiology Currently, magnetic resonance imaging scanning is only recommended in atypical cases (ie, young age, no vascular risk factors). The purpose of this multicenter study is to determine whether central nervous system abnormalities are detected in patients who otherwise would not have neuroimaging. Investigator: Stacey L. Pineles, MD Optical Coherence Tomography in the Newborn Eye The purpose of this study is to better characterize the retina and optic nerve in newborns using spectraldomain optical coherence tomography (SD-OCT). SD-OCT has been used by doctors for more than five years to help diagnose and treat adults with eye diseases, but it has never been studied in newborns, where it could potentially help in the diagnoses of glaucoma, optic nerve hypoplasia, foveal hypoplasia, and colobomata, among many other disorders. Investigator: Sherwin J. Isenberg, MD 112 Appendices | Clinical Research Studies Prevention of Visual Impairment In School-Age Children In this community-based participatory intervention to promote the use of eyeglasses in schools, first- and second-grade students with refractive errors receive two pairs of eyeglasses, with one pair staying at home and the other in the classroom. School nurses collaborate with teachers in monitoring the use of eyeglasses in the classroom, and parents receive eye care education. Investigators: Gergana Kodjebacheva, PhD; and Anne L. Coleman, MD, PhD A Randomized Trail of Levadopa as Treatment for Residual Amblyopia (ATS17) The objective of this study is to compare the efficacy and safety of oral levodopa and patching versus oral placebo and patching in children 7 to
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Jules Stein Eye Institute ANNUAL RE
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ii Jules and Doris Stein The legacy
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iv Board of Trustees Board of Trust
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vi Jules Stein Mission Statement Th
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2 Highlights Dear Friends, I am ple
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Institute Brings a Pediatric-Friend
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Honors Each year, as part of their
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Research Research is a key componen
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Adaptive Robotics for Ocular Surger
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17th Annual Vision Science Conferen
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Audrey and Jack Skirball continued
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The Ahmanson Foundation Awards Gran
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Major Gifts over $25,000 American G
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Jules Stein Chair in Ophthalmology
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Community Outreach Much of the Jule
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Vision Education Vision IN-School (
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anthony J. aldave, mD Associate Pro
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Richard s. Baker, mD Associate Prof
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30 Faculty | Bok Dean Bok, PhD Doll
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Richard casey, mD Clinical Professo
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Joseph L. Demer, mD, PhD Leonard Ap
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Gordon L. Fain, PhD Distinguished P
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Joann a. Giaconi, mD Assistant Clin
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Robert alan Goldberg, mD Karen and
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michael B. Gorin, mD, PhD Harold an
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Gary N. holland, mD Jack H. Skirbal
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Wayne L. hubbell, PhD Jules Stein P
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sherwin J. Isenberg, mD Laraine and
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simon K. Law, mD, PharmD Associate
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colin a. mccannel, mD Associate Pro
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Kevin m. miller, mD Kolokotrones Pr
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Kouros Nouri-mahdavi, mD, msc Assis
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stacy L. Pineles, mD Assistant Prof
Page 67 and 68: David sarraf, mD Associate Clinical
Page 69 and 70: hui sun, PhD Associate Professor of
Page 71 and 72: Federico G. Velez, mD Assistant Cli
Page 73 and 74: David s. Williams, PhD Jules and Do
Page 75 and 76: 68 Faculty INsTITuTe memBeRs BaseD
Page 77 and 78: 70 Faculty PROFessIONaL ReseaRch se
Page 79 and 80: 72 Faculty michael D. Olson, OD, Ph
Page 81 and 82: 74 Faculty Vicki chan, mD Associate
Page 84 and 85: Programs
Page 86 and 87: Nearly all the evaluation, diagnosi
Page 88 and 89: Diabetic Eye Disease and Retinal Va
Page 90 and 91: Orbital Disease Center The Orbital
Page 92 and 93: Ophthalmic Photography Clinical Lab
Page 94 and 95: Didactic Education Residents receiv
Page 96 and 97: Fellowship in Cornea-External Ocula
Page 98 and 99: Fellowship in Vitreoretinal Disease
Page 100 and 101: Appendices
Page 102 and 103: Assistant Clinical Professor of Oph
Page 104 and 105: Educational Offerings Ophthalmology
Page 106 and 107: Research Contracts and Grants Fisca
Page 108 and 109: Longitudinal Studies of Ocular Comp
Page 110 and 111: Biochemical and Genetic Analysis of
Page 112 and 113: Age-Related Eye Disease Study II Em
Page 114 and 115: Corneal Endothelial Cell Changes in
Page 116 and 117: Genetics of Age-Related Maculopathy
Page 120 and 121: Publications of the Full-Time Facul
Page 122 and 123: Li X, Bykhovskaya Y, Haritunians T,
Page 124 and 125: Kalyani PS, Holland GN, Fawzi AA, A
Page 126 and 127: Dean AW, Glasgow BJ. Mass spectrome
Page 128 and 129: Appendices | Publications of the Fu
Page 130 and 131: The emblem of the Jules Stein Eye I
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