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Natik Piri, PhD Associate Professor of Ophthalmology Member of the Jules Stein Eye Institute ReseaRch summaRy Retinal Ganglion Cell Degeneration in Optic Neuropathies and Neuroprotection The main directions in Dr. Piri’s research are defining the mechanisms leading to retinal ganglion cell (RGC) degeneration in glaucomatous neuropathy; developing strategies for preserving RGCs against neurodegeneration; and identifying and characterizing the genes critical for RGC function and integrity. Different types of RGCs have been identified based on their morphological and physiological characteristics, yet current knowledge of RGC molecular biology is very limited. Dr. Piri has initiated a study to identify the genes expressed in RGCs. Characterization of RGC-expressed genes is fundamental to a better understanding of normal RGC physiology and pathophysiology. Another area of investigation focuses on understanding the degeneration of RGCs and their axons, which is a hallmark of glaucoma. Dr. Piri’s laboratory is analyzing retinal gene expression profiles from the glaucoma model with the aim of identifying factors involved in the initiation and execution of RGC apoptosis. Study results have implicated several members of the crystallin superfamily in this process, including alpha crystallins. Dr. Piri is also studying the involvement of oxidative stress and proteins of the thioredoxin system, particularly in RGC degeneration in the glaucoma model, and the neuroprotective effects of these proteins against glaucomatous RGC death. Public Service Reviewer for many scientific journals Research Grants National Eye Institute: The Neuroprotective Effect of HSP72 Induction in Experimental Glaucoma, 9/30/09–8/31/14 Faculty | Piri 59
David sarraf, mD Associate Clinical Professor of Ophthalmology Member of the Jules Stein Eye Institute ReseaRch summaRy Age-Related Macular Degeneration and Crystalline Maculopathy Dr. Sarraf has credits in approximately 50 publications (including chapters, review papers, case reports, case series, and scientific papers) and has published 40 PubMed articles. His most important contribution involves wet age-related macular degeneration, specifically the subject of retinal pigment epithelial (RPE) detachment and RPE tears. Dr. Sarraf was one of the first to describe RPE tears and to determine the risk factors leading to RPE tears after anti-vascular endothelial growth factor (VEGF) therapy. He recently published a new grading system for RPE tears and was one of the first to describe evolving RPE tears both pre- and post-anti-VEGF therapy. Dr. Sarraf has received a financial grant to conduct a prospective trial (nearing completion) comparing low-dose and highdose Lucentis therapy for fibrovascular pigment epithelial detachments (PEDs). This study has allowed further insight into therapy for PEDs and the risk factors and mechanisms leading to RPE tears. Dr. Sarraf has also identified novel retinal diseases, specifically as pertains to crystalline retinopathy. He was the first to describe West African crystalline maculopathy and Triamcinolone-associated crystalline maculopathy. Studies on both topics were published in the Archives of Ophthalmology. 60 Faculty | Sarraf Public Service Director, Annual Jules Stein Eye Institute and Doheny Eye Institute Comprehensive Ophthalmology Review Course Co-Director, Los Angeles Imaging Conference for Retinal Specialists Co-Director, Western Retina Study Meeting, Los Angeles Imaging Conference for Retinal Specialists Reviewer for many scientific journals Honors Invited to become a member of the Gass Club Research Grants Southern California Desert Retina Consultants: Ranibizumab (Lucentis) for Treating Submacular Vascularized PED, 7/2/10–6/30/12
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Jules Stein Eye Institute ANNUAL RE
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ii Jules and Doris Stein The legacy
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iv Board of Trustees Board of Trust
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vi Jules Stein Mission Statement Th
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2 Highlights Dear Friends, I am ple
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Institute Brings a Pediatric-Friend
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Honors Each year, as part of their
Page 15 and 16: Research Research is a key componen
Page 17 and 18: Adaptive Robotics for Ocular Surger
Page 19 and 20: 17th Annual Vision Science Conferen
Page 21 and 22: Audrey and Jack Skirball continued
Page 23 and 24: The Ahmanson Foundation Awards Gran
Page 25 and 26: Major Gifts over $25,000 American G
Page 27 and 28: Jules Stein Chair in Ophthalmology
Page 29 and 30: Community Outreach Much of the Jule
Page 31 and 32: Vision Education Vision IN-School (
Page 33 and 34: anthony J. aldave, mD Associate Pro
Page 35 and 36: Richard s. Baker, mD Associate Prof
Page 37 and 38: 30 Faculty | Bok Dean Bok, PhD Doll
Page 39 and 40: Richard casey, mD Clinical Professo
Page 41 and 42: Joseph L. Demer, mD, PhD Leonard Ap
Page 43 and 44: Gordon L. Fain, PhD Distinguished P
Page 45 and 46: Joann a. Giaconi, mD Assistant Clin
Page 47 and 48: Robert alan Goldberg, mD Karen and
Page 49 and 50: michael B. Gorin, mD, PhD Harold an
Page 51 and 52: Gary N. holland, mD Jack H. Skirbal
Page 53 and 54: Wayne L. hubbell, PhD Jules Stein P
Page 55 and 56: sherwin J. Isenberg, mD Laraine and
Page 57 and 58: simon K. Law, mD, PharmD Associate
Page 59 and 60: colin a. mccannel, mD Associate Pro
Page 61 and 62: Kevin m. miller, mD Kolokotrones Pr
Page 63 and 64: Kouros Nouri-mahdavi, mD, msc Assis
Page 65: stacy L. Pineles, mD Assistant Prof
Page 69 and 70: hui sun, PhD Associate Professor of
Page 71 and 72: Federico G. Velez, mD Assistant Cli
Page 73 and 74: David s. Williams, PhD Jules and Do
Page 75 and 76: 68 Faculty INsTITuTe memBeRs BaseD
Page 77 and 78: 70 Faculty PROFessIONaL ReseaRch se
Page 79 and 80: 72 Faculty michael D. Olson, OD, Ph
Page 81 and 82: 74 Faculty Vicki chan, mD Associate
Page 84 and 85: Programs
Page 86 and 87: Nearly all the evaluation, diagnosi
Page 88 and 89: Diabetic Eye Disease and Retinal Va
Page 90 and 91: Orbital Disease Center The Orbital
Page 92 and 93: Ophthalmic Photography Clinical Lab
Page 94 and 95: Didactic Education Residents receiv
Page 96 and 97: Fellowship in Cornea-External Ocula
Page 98 and 99: Fellowship in Vitreoretinal Disease
Page 100 and 101: Appendices
Page 102 and 103: Assistant Clinical Professor of Oph
Page 104 and 105: Educational Offerings Ophthalmology
Page 106 and 107: Research Contracts and Grants Fisca
Page 108 and 109: Longitudinal Studies of Ocular Comp
Page 110 and 111: Biochemical and Genetic Analysis of
Page 112 and 113: Age-Related Eye Disease Study II Em
Page 114 and 115: Corneal Endothelial Cell Changes in
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Genetics of Age-Related Maculopathy
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PET/CT Imaging for Early Detection
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Publications of the Full-Time Facul
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Li X, Bykhovskaya Y, Haritunians T,
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Kalyani PS, Holland GN, Fawzi AA, A
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Dean AW, Glasgow BJ. Mass spectrome
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Appendices | Publications of the Fu
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The emblem of the Jules Stein Eye I
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