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Joseph caprioli, mD David May II Professor of Ophthalmology Chief of the Glaucoma Division Member of the Jules Stein Eye Institute ReseaRch summaRy Causes and New Treatments for Glaucoma Dr. Caprioli’s long-term objective in his clinical and basic research is to identify those individuals at greatest risk for visual loss and to implement new treatment strategies to prevent blindness. Currently, the only tool that physicians have to treat glaucoma is reduction of intra- ocular pressure. This treatment does not prevent visual loss in a substantial proportion of patients whose damage progresses quickly. The development of effective neuroprotective avenues of treatment will be a hallmark advance to eliminate blindness from this disease. evaluation of methods to measure Rates of Glaucomatous Optic Nerve Damage Accurate assessment of optic nerve and nerve fiber layer is important to the early detection and timely treatment of glaucoma. Studies are underway to develop novel structural measures of the optic nerve and nerve fiber layer, which are sensitive and specific for early and progressive glaucomatous optic nerve damage. The goals of this work include identifying clinically implementable techniques to measure the rate of progressive damage. It is unlikely that a single structural or functional technique will be best throughout the course of the disease, and different methods will need to be applied at different stages to best measure disease progression. molecular mechanisms of Retinal Ganglion cell Damage and Neuroprotective approaches to Treatment Basic science research under Dr. Caprioli’s direction involves the mechanisms of glaucomatous optic nerve damage. The stress protein response in a glaucoma model is being intensively studied. An important goal in this research is to identify neuroprotective drugs that prevent the death of retinal ganglion cells in mammalian models of glaucoma, and to apply these findings to clinical trials of human glaucoma. Public Service Chair, American Academy of Ophthalmology, Committee on Practice Improvement Clinical Volunteer, Venice Family Clinic Editorial Board Member, American Journal of Ophthalmology, Investigative Ophthalmology and Visual Science, and Journal of Glaucoma Reviewer for many scientific journals Honors 2011 Life Achievement Award, American Academy of Ophthalmology Research Grants National Eye Institute: The Neuroprotective Effect of HSP72 Induction in Experimental Glaucoma (Principal Investigator: Natik Piri, PhD), 9/30/09–8/31/14 Outcome Sciences, Inc: Comparing the Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma, 4/29/11–4/28/13 Massachusetts Eye and Ear Infirmary: A Novel Computer Algorithm to Predict Visual Field Function Based on Structural Imaging in Glaucoma, 7/15/10–7/15/11 Faculty | Caprioli 31
Richard casey, mD Clinical Professor of Ophthalmology Associate Member of the Jules Stein Eye Institute ReseaRch summaRy Cornea External Disease Dr. Casey’s research is focused on understanding the causes of corneal disease and developing or improving treatments for patients with these disorders. He is collaborating with the Glaucoma and Ophthalmic Pathology Divisions on clinical research projects to understand the nature of comorbid conditions, such as glaucoma and dry eye disease. For dry eye disease, Dr. Casey is engaged in research to evaluate the ocular surface of patients undergoing corneal transplantation surgery to establish previously undescribed clinicalpathologic correlation with tear insufficiency and corneal epithelial abnormalities. The goal of these investigations is to improve the success of corneal transplantation in high-risk patients with the comorbid conditions of glaucoma and separately tear insufficiency. Public health services/health access Dr. Casey has elected to dedicate a significant portion of his professional career to improving access to health care in specific underserved communities of Los Angeles. He has focused on assessing unmet needs in vision health and developing innovative strategies to meet these deficits. He has established the Los Angeles Ophthalmology Medical Group, a comprehensive eye care service entity, which is currently engaged in a partnership to provide eye care services to facilities of the Los Angeles County, Department of Health Services in South Los Angeles. 32 Faculty | Casey Public Service Lead Physician, Martin Luther King, Jr. Multi-Service Ambulatory Care Center President, Los Angeles Ophthalmology Medical Group, Inc.
Page 1 and 2: Jules Stein Eye Institute ANNUAL RE
Page 3 and 4: ii Jules and Doris Stein The legacy
Page 5 and 6: iv Board of Trustees Board of Trust
Page 7 and 8: vi Jules Stein Mission Statement Th
Page 9 and 10: 2 Highlights Dear Friends, I am ple
Page 11 and 12: Institute Brings a Pediatric-Friend
Page 13 and 14: Honors Each year, as part of their
Page 15 and 16: Research Research is a key componen
Page 17 and 18: Adaptive Robotics for Ocular Surger
Page 19 and 20: 17th Annual Vision Science Conferen
Page 21 and 22: Audrey and Jack Skirball continued
Page 23 and 24: The Ahmanson Foundation Awards Gran
Page 25 and 26: Major Gifts over $25,000 American G
Page 27 and 28: Jules Stein Chair in Ophthalmology
Page 29 and 30: Community Outreach Much of the Jule
Page 31 and 32: Vision Education Vision IN-School (
Page 33 and 34: anthony J. aldave, mD Associate Pro
Page 35 and 36: Richard s. Baker, mD Associate Prof
Page 37: 30 Faculty | Bok Dean Bok, PhD Doll
Page 41 and 42: Joseph L. Demer, mD, PhD Leonard Ap
Page 43 and 44: Gordon L. Fain, PhD Distinguished P
Page 45 and 46: Joann a. Giaconi, mD Assistant Clin
Page 47 and 48: Robert alan Goldberg, mD Karen and
Page 49 and 50: michael B. Gorin, mD, PhD Harold an
Page 51 and 52: Gary N. holland, mD Jack H. Skirbal
Page 53 and 54: Wayne L. hubbell, PhD Jules Stein P
Page 55 and 56: sherwin J. Isenberg, mD Laraine and
Page 57 and 58: simon K. Law, mD, PharmD Associate
Page 59 and 60: colin a. mccannel, mD Associate Pro
Page 61 and 62: Kevin m. miller, mD Kolokotrones Pr
Page 63 and 64: Kouros Nouri-mahdavi, mD, msc Assis
Page 65 and 66: stacy L. Pineles, mD Assistant Prof
Page 67 and 68: David sarraf, mD Associate Clinical
Page 69 and 70: hui sun, PhD Associate Professor of
Page 71 and 72: Federico G. Velez, mD Assistant Cli
Page 73 and 74: David s. Williams, PhD Jules and Do
Page 75 and 76: 68 Faculty INsTITuTe memBeRs BaseD
Page 77 and 78: 70 Faculty PROFessIONaL ReseaRch se
Page 79 and 80: 72 Faculty michael D. Olson, OD, Ph
Page 81 and 82: 74 Faculty Vicki chan, mD Associate
Page 84 and 85: Programs
Page 86 and 87: Nearly all the evaluation, diagnosi
Page 88 and 89:
Diabetic Eye Disease and Retinal Va
Page 90 and 91:
Orbital Disease Center The Orbital
Page 92 and 93:
Ophthalmic Photography Clinical Lab
Page 94 and 95:
Didactic Education Residents receiv
Page 96 and 97:
Fellowship in Cornea-External Ocula
Page 98 and 99:
Fellowship in Vitreoretinal Disease
Page 100 and 101:
Appendices
Page 102 and 103:
Assistant Clinical Professor of Oph
Page 104 and 105:
Educational Offerings Ophthalmology
Page 106 and 107:
Research Contracts and Grants Fisca
Page 108 and 109:
Longitudinal Studies of Ocular Comp
Page 110 and 111:
Biochemical and Genetic Analysis of
Page 112 and 113:
Age-Related Eye Disease Study II Em
Page 114 and 115:
Corneal Endothelial Cell Changes in
Page 116 and 117:
Genetics of Age-Related Maculopathy
Page 118 and 119:
PET/CT Imaging for Early Detection
Page 120 and 121:
Publications of the Full-Time Facul
Page 122 and 123:
Li X, Bykhovskaya Y, Haritunians T,
Page 124 and 125:
Kalyani PS, Holland GN, Fawzi AA, A
Page 126 and 127:
Dean AW, Glasgow BJ. Mass spectrome
Page 128 and 129:
Appendices | Publications of the Fu
Page 130 and 131:
The emblem of the Jules Stein Eye I
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