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steven D. schwartz, mD Ahmanson Professor of Ophthalmology Chief of the Retina Division Director of the UCLA Diabetic Eye Disease and Retinal Vascular Center Director of the Macula Center Professor-in-Residence of Ophthalmology Member of the Jules Stein Eye Institute ReseaRch summaRy Stem Cell Research Dr. Schwartz is leading two new clinical trials testing the use of stem cell-derived retinal pigment epithelial cells to address vision loss in people suffering from Stargardt macular dystrophy and dry age-related macular degeneration. Retinal Diseases Dr. Schwartz’s primary areas of research include early diagnosis and treatment of diseases such as retinopathy of prematurity (ROP), diabetic eye disease, and macular degeneration. Additionally, his focus includes development and evaluation of novel medical device technologies, imaging technologies, surgical equipment (including surgical robots), and drug-delivery systems, with particular emphasis on diagnostic and treatment applications. Dr. Schwartz’s clinical research focuses on trials of novel pharmacotherapeutic agents to discover treatments for both wet and dry age-related macular degeneration, ROP, and diabetic retinopathy. Through innovative teleophthalmological approaches to screen for eye diseases, such as diabetic retinopathy and ROP, Dr. Schwartz is dedicated to improving both the quality of and access to specialized ophthalmology care. Currently, a collaborative program with UCLA’s Gonda Diabetes Center and Venice Family Clinic is underway, in which screening for diabetic retinopathy is conducted with a nonmydriatic camera (a camera that does not require dilation of the eyes) as part of each patient’s regular diabetes treatment. Results are telecommunicated to specialists at the Jules Stein Eye Institute for interpretation and follow up. Public Service Board Member, American Society of Retinal Specialists Program Committee Member, Association for Research in Vision and Ophthalmology Diabetic Eye Disease Screening, Venice Family Clinic Honors 2012 Southern California Super Doctors Keynote lecturer at the UCLA IMED Seminar Series with Dr. Robert Lanza Research Grants Advanced Cell Technology, Inc.: Research with Retinal Cells Derived from Stem Cells for Age-Related Macular Degeneration, 4/5/11–4/4/13 Advanced Cell Technology, Inc.: Research with Retinal Cells Derived from Stem Cells for Stargardt Macular Dystrophy, 3/23/11–3/22/13 Allergan Sales, LLC: DEX PS DDS Applicator System in the Treatment of Patients with Diabetic Macular Edema, 8/25/05–12/31/13 Emmes Corp.: Age-Related Eye Disease Study II, 1/1/06–12/31/12 Gen Vec, Inc.: GV-000.000: Gene Transfer Product Candidates in Clinical Development, 2/27/09–2/26/24 Genentech, Inc.: Ranibizumab Injection, 10/5/07–8/31/12 Lowy Medical Research Institute/NEI: Macular Telangiectasia, 9/1/05–8/31/13 ThromboGenics, Inc.: Resolution of Vitreomacular Adhesion (VMA) Associated with Neovascular Age-Related Macular Degeneration (AMD) with Intravitreal Microplasm, 6/30/09–9/1/13 Faculty | Schwartz 61
hui sun, PhD Associate Professor of Physiology and Ophthalmology Member of the Jules Stein Eye Institute ReseaRch summaRy Molecular Mechanism of Vitamin A Transport for Vision; Identification of New Therapeutic Targets for Blinding Diseases Dr. Sun’s laboratory studies the molecular mechanism of vitamin A transport for vision and new therapeutic targets for blinding diseases such as age-related macular degeneration. Vitamin A deficiency is the leading cause of blindness in third world countries, and age-related macular degeneration is a leading cause of blindness in the developed world. Vitamin A is essential for vision because it is the precursor for the chromophore of photoreceptor proteins and also plays critical roles in eye development. Plasma retinol binding protein (RBP) is the principal carrier of vitamin A in the blood and is essential for mobilizing the hepatic vitamin A store. Dr. Sun’s laboratory identified the long-sought RBP receptor as a multitransmembrane protein of previously unknown function. It functions simultaneously as a membrane receptor and a membrane transporter that mediates cellular uptake of vitamin A. The RBP/ RBP receptor system represents a rare example in eukaryotic cells of a small molecule delivery system that involves an extracellular carrier protein but does not depend on endocytosis. Human genetic studies found that the RBP receptor is essential for the formation of the human eye and many other organs, consistent with the critical role of vitamin A in embryonic development. Dr. Sun’s laboratory is using a variety of techniques to study this membrane transport system. 62 Faculty | Sun Public Service Ad hoc Reviewer, National Science Foundation, National Eye Institute (United States), Health Research Board (Ireland), and Medical Research Council (United Kingdom) Reviewer for many scientific journals Research Grants National Eye Institute: Molecular Mechanism of Vitamin A Uptake for Vision, 9/30/07–8/31/12 Howard Hughes Medical Institute, 9/1/09–8/31/15 Research to Prevent Blindness Ophthalmic Research Award, 1/1/12–12/31/14
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Jules Stein Eye Institute ANNUAL RE
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ii Jules and Doris Stein The legacy
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iv Board of Trustees Board of Trust
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vi Jules Stein Mission Statement Th
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2 Highlights Dear Friends, I am ple
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Institute Brings a Pediatric-Friend
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Honors Each year, as part of their
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Research Research is a key componen
Page 17 and 18: Adaptive Robotics for Ocular Surger
Page 19 and 20: 17th Annual Vision Science Conferen
Page 21 and 22: Audrey and Jack Skirball continued
Page 23 and 24: The Ahmanson Foundation Awards Gran
Page 25 and 26: Major Gifts over $25,000 American G
Page 27 and 28: Jules Stein Chair in Ophthalmology
Page 29 and 30: Community Outreach Much of the Jule
Page 31 and 32: Vision Education Vision IN-School (
Page 33 and 34: anthony J. aldave, mD Associate Pro
Page 35 and 36: Richard s. Baker, mD Associate Prof
Page 37 and 38: 30 Faculty | Bok Dean Bok, PhD Doll
Page 39 and 40: Richard casey, mD Clinical Professo
Page 41 and 42: Joseph L. Demer, mD, PhD Leonard Ap
Page 43 and 44: Gordon L. Fain, PhD Distinguished P
Page 45 and 46: Joann a. Giaconi, mD Assistant Clin
Page 47 and 48: Robert alan Goldberg, mD Karen and
Page 49 and 50: michael B. Gorin, mD, PhD Harold an
Page 51 and 52: Gary N. holland, mD Jack H. Skirbal
Page 53 and 54: Wayne L. hubbell, PhD Jules Stein P
Page 55 and 56: sherwin J. Isenberg, mD Laraine and
Page 57 and 58: simon K. Law, mD, PharmD Associate
Page 59 and 60: colin a. mccannel, mD Associate Pro
Page 61 and 62: Kevin m. miller, mD Kolokotrones Pr
Page 63 and 64: Kouros Nouri-mahdavi, mD, msc Assis
Page 65 and 66: stacy L. Pineles, mD Assistant Prof
Page 67: David sarraf, mD Associate Clinical
Page 71 and 72: Federico G. Velez, mD Assistant Cli
Page 73 and 74: David s. Williams, PhD Jules and Do
Page 75 and 76: 68 Faculty INsTITuTe memBeRs BaseD
Page 77 and 78: 70 Faculty PROFessIONaL ReseaRch se
Page 79 and 80: 72 Faculty michael D. Olson, OD, Ph
Page 81 and 82: 74 Faculty Vicki chan, mD Associate
Page 84 and 85: Programs
Page 86 and 87: Nearly all the evaluation, diagnosi
Page 88 and 89: Diabetic Eye Disease and Retinal Va
Page 90 and 91: Orbital Disease Center The Orbital
Page 92 and 93: Ophthalmic Photography Clinical Lab
Page 94 and 95: Didactic Education Residents receiv
Page 96 and 97: Fellowship in Cornea-External Ocula
Page 98 and 99: Fellowship in Vitreoretinal Disease
Page 100 and 101: Appendices
Page 102 and 103: Assistant Clinical Professor of Oph
Page 104 and 105: Educational Offerings Ophthalmology
Page 106 and 107: Research Contracts and Grants Fisca
Page 108 and 109: Longitudinal Studies of Ocular Comp
Page 110 and 111: Biochemical and Genetic Analysis of
Page 112 and 113: Age-Related Eye Disease Study II Em
Page 114 and 115: Corneal Endothelial Cell Changes in
Page 116 and 117: Genetics of Age-Related Maculopathy
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PET/CT Imaging for Early Detection
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Publications of the Full-Time Facul
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Li X, Bykhovskaya Y, Haritunians T,
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Kalyani PS, Holland GN, Fawzi AA, A
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Dean AW, Glasgow BJ. Mass spectrome
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Appendices | Publications of the Fu
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The emblem of the Jules Stein Eye I
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