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Tara a. mccannel, mD, PhD Assistant Professor of Ophthalmology Director of the Ophthalmic Oncology Center Member of the Jules Stein Eye Institute ReseaRch summaRy Metastatic Ocular Melanoma Dr. McCannel’s primary research interest is metastatic ocular melanoma. Under her direction, the Ophthalmic Oncology Laboratory is studying molecular markers in ocular melanoma to provide prognostic information to patients and advance understanding of metastatic disease. Discovery of candidate genes from tissue of patients undergoing surgical treatment for ocular melanoma is being explored. This information will be important to establish a better understanding of the biology of metastatic ocular melanoma and help develop better treatments for this cancer. New modalities are being investigated to predict, detect, and ultimately treat choroidal melanoma metastasis. surgical approaches to Vitreoretinal Disease and cancer Dr. McCannel is both a vitreoretinal surgeon and an ophthalmic oncologist. She manages the spectrum of vitreoretinal disease in addition to the surgical management of ocular melanoma, allowing patients to benefit maximally from her wide range of surgical prognostic and therapeutic expertise. Vitrectomy with silicone oil placement is a novel therapeutic strategy, which was discovered at UCLA to reduce radiation exposure to the healthy structures of the eye during plaque surgery for melanoma treatment. Dr. McCannel offers this potentially sight-saving technique to patients who need radiation treatment. health Psychology and Ocular melanoma Central to incorporating an integrative approach to health care, the concerns and wishes of the patient as a whole are important aspects of cancer management. In collaboration with the UCLA Department of Health Psychology and the Jonsson Comprehensive Cancer Center, Dr. McCannel works closely with health psychologists who are interested in providing clinical care while researching factors, which predict psychological adjustment to cancer. Public Service Reviewer for many scientific journals Research Grants American Association of Cancer Research, Career Development Award for Translational Cancer Research: High Resolution Cytogenetic Study of Archival Metastatic Choroidal Melanoma, 7/1/08–12/30/11 Faculty | McCannel 53
Kevin m. miller, mD Kolokotrones Professor of Clinical Ophthalmology Chief of the Comprehensive Ophthalmology Division Member of the Jules Stein Eye Institute ReseaRch summaRy Cataract and Refractive Surgery Dr. Miller’s research interests are in cataract and refractive surgery, intraocular lenses, artificial iris implants, ophthalmic optics, surgical devices, and surgical outcomes. Dr. Miller’s clinical practice focuses primarily on refractive cataract surgery and the surgical correction of presbyopia and astigmatism with premium technology intraocular lenses. He developed an astigmatism management service for treating corneal astigmatism at the time of cataract surgery that optimizes postoperative uncorrected visual acuity. He developed a nomogram for peripheral corneal relaxing incisions and participated in the clinical trial of the world’s most popular toric intraocular lens. He described a nonparametric multivariate technique for comparing astigmatism outcomes between treatment groups. In addition to refractive cataract surgery, he also performs DSEK, LASIK, and other cornea-based laser refractive procedures. Dr. Miller runs several clinical trials of artificial iris implants to treat congenital and acquired aniridia. The multicenter Ophtec 311 clinical trial is investigat- ing a colored iris reconstruction lens. Dr. Miller has an individual device exemption from the FDA to study Morcher GmbH artificial iris implants. He is the only surgeon in the United States who is permitted by the FDA to implant Morcher devices at this time. He is also studying a custom artificial iris implant from Dr. Schmidt Intraocularlinsen, a subsidiary of HumanOptics AG. All of these devices are showing promising results in patients who suffer from congenital and acquired iris defects. 54 Faculty | Miller Public Service Course Director, Southern California Cataract Surgery Course for Residents and Fellows American Academy of Ophthalmology, Skills Transfer Course Advisory Committee American Academy of Ophthalmology/Physician Consortium for Performance Improvement/National Committee for Quality Assurance Eye Care Work Group, Surgical Management Subgroup Committee American Academy of Ophthalmology, Annual Meeting Program Committee, Cataract Subcommittee Column Editor, American Society of Cataract and Refractive Surgery, EyeWorld Magazine American Society of Cataract and Refractive Surgery, Retina Clinical Committee World Congress of Ophthalmology 2012 Biannual Meeting Program Planning Committee, Cataract Section International Editorial Board, Oftalmologia Em Foco Faculty of 1000, Post-Publication Peer Review, Lens Disorders Section American Society of Cataract and Refractive Surgery Skills Transfer Subcommittee Reviewer for many scientific journals Research Grants Physical Optics Corp./NIH: Clinical Testing of the Tracking Adaptive-Optic Scanning Laser Ophthalmoscope, 1/15/11–9/29/11
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Jules Stein Eye Institute ANNUAL RE
Page 3 and 4:
ii Jules and Doris Stein The legacy
Page 5 and 6:
iv Board of Trustees Board of Trust
Page 7 and 8:
vi Jules Stein Mission Statement Th
Page 9 and 10: 2 Highlights Dear Friends, I am ple
Page 11 and 12: Institute Brings a Pediatric-Friend
Page 13 and 14: Honors Each year, as part of their
Page 15 and 16: Research Research is a key componen
Page 17 and 18: Adaptive Robotics for Ocular Surger
Page 19 and 20: 17th Annual Vision Science Conferen
Page 21 and 22: Audrey and Jack Skirball continued
Page 23 and 24: The Ahmanson Foundation Awards Gran
Page 25 and 26: Major Gifts over $25,000 American G
Page 27 and 28: Jules Stein Chair in Ophthalmology
Page 29 and 30: Community Outreach Much of the Jule
Page 31 and 32: Vision Education Vision IN-School (
Page 33 and 34: anthony J. aldave, mD Associate Pro
Page 35 and 36: Richard s. Baker, mD Associate Prof
Page 37 and 38: 30 Faculty | Bok Dean Bok, PhD Doll
Page 39 and 40: Richard casey, mD Clinical Professo
Page 41 and 42: Joseph L. Demer, mD, PhD Leonard Ap
Page 43 and 44: Gordon L. Fain, PhD Distinguished P
Page 45 and 46: Joann a. Giaconi, mD Assistant Clin
Page 47 and 48: Robert alan Goldberg, mD Karen and
Page 49 and 50: michael B. Gorin, mD, PhD Harold an
Page 51 and 52: Gary N. holland, mD Jack H. Skirbal
Page 53 and 54: Wayne L. hubbell, PhD Jules Stein P
Page 55 and 56: sherwin J. Isenberg, mD Laraine and
Page 57 and 58: simon K. Law, mD, PharmD Associate
Page 59: colin a. mccannel, mD Associate Pro
Page 63 and 64: Kouros Nouri-mahdavi, mD, msc Assis
Page 65 and 66: stacy L. Pineles, mD Assistant Prof
Page 67 and 68: David sarraf, mD Associate Clinical
Page 69 and 70: hui sun, PhD Associate Professor of
Page 71 and 72: Federico G. Velez, mD Assistant Cli
Page 73 and 74: David s. Williams, PhD Jules and Do
Page 75 and 76: 68 Faculty INsTITuTe memBeRs BaseD
Page 77 and 78: 70 Faculty PROFessIONaL ReseaRch se
Page 79 and 80: 72 Faculty michael D. Olson, OD, Ph
Page 81 and 82: 74 Faculty Vicki chan, mD Associate
Page 84 and 85: Programs
Page 86 and 87: Nearly all the evaluation, diagnosi
Page 88 and 89: Diabetic Eye Disease and Retinal Va
Page 90 and 91: Orbital Disease Center The Orbital
Page 92 and 93: Ophthalmic Photography Clinical Lab
Page 94 and 95: Didactic Education Residents receiv
Page 96 and 97: Fellowship in Cornea-External Ocula
Page 98 and 99: Fellowship in Vitreoretinal Disease
Page 100 and 101: Appendices
Page 102 and 103: Assistant Clinical Professor of Oph
Page 104 and 105: Educational Offerings Ophthalmology
Page 106 and 107: Research Contracts and Grants Fisca
Page 108 and 109: Longitudinal Studies of Ocular Comp
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Biochemical and Genetic Analysis of
Page 112 and 113:
Age-Related Eye Disease Study II Em
Page 114 and 115:
Corneal Endothelial Cell Changes in
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Genetics of Age-Related Maculopathy
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PET/CT Imaging for Early Detection
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Publications of the Full-Time Facul
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Li X, Bykhovskaya Y, Haritunians T,
Page 124 and 125:
Kalyani PS, Holland GN, Fawzi AA, A
Page 126 and 127:
Dean AW, Glasgow BJ. Mass spectrome
Page 128 and 129:
Appendices | Publications of the Fu
Page 130 and 131:
The emblem of the Jules Stein Eye I
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