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Gabriel h. Travis, mD Charles Kenneth Feldman Professor of Ophthalmology Associate Director of the Jules Stein Eye Institute Co-Chief of the Vision Science Division ReseaRch summaRy Biochemistry of Vertebrate Photoreceptors and Mechanisms of Retinal Degeneration Dr. Travis’ laboratory uses biochemical and genetic approaches to study the visual cycle and its role in retinal and macular degenerations. Vision in vertebrates is mediated by two types of light-sensitive cells: rods and cones. These cells contain light-detecting molecules called opsin pigments. Detection of a single light particle bleaches the opsin pigment. Restoring light sensitivity to a bleached opsin involves an enzymatic pathway called the visual cycle. Mutations in the genes for many proteins of the visual cycle cause inherited blinding diseases. One project in Dr. Travis’ laboratory studies the function of a transporter protein in rods and cones called ABCA4. Mutations in the human ABCA4 gene cause recessive Stargardt macular degeneration and cone-rod dystrophy. Dr. Travis’ group generated mice with a null mutation in this gene. Biochemical analysis of the phenotype in these ABCA4 “knockout” mice led them to the function of ABCA4 in photoreceptors, and the biochemical etiology of Stargardt disease. This understanding suggested a pharmacological strategy to reverse the biochemical defect in patients with Stargardt disease and agerelated macular degeneration. A phase II clinical trial is currently underway to test a drug based on this strategy as a treatment for age-related macular degeneration. Another ongoing project in Dr. Travis’ laboratory characterizes Rpe65, which catalyzes the critical isomeriza- tion step in the visual cycle. Previously, Dr. Travis and co-workers identified Rpe65 as the retinoid isomerase. Still another project in Dr. Travis’ laboratory concerns the mechanism of visual-pigment regeneration in cone photoreceptors. Despite the importance of cones, little is known about how visual pigments are replenished to permit sustained vision under daylight conditions. Recent results from Dr. Travis’ group point to the existence of a new enzymatic pathway for regenerating visual pigments in cones. His group is currently working to purify and clone the enzymes that define this new biochemical pathway. Public Service Scientific Advisory Panel Member, the Karl Kirchgessner Foundation Vision Science Program Grant Reviewer, National Institutes of Health: The Biology and Diseases of the Posterior Eye Study Section Reviewer, Howard Hughes Medical Institute Investigators Reviewer for many scientific journals Research Grants California Institute for Regenerative Medicine: Development of a Stem Cell-Based Transplantation Strategy for Treating Age-Related Macular Degeneration (Principal Investigator, with other investigators), 11/1/09–10/31/12 National Eye Institute: The Role of Muller Cells in Visual Pigment Regeneration, 3/1/08–2/28/13 National Eye Institute: Vision Science Training Grant for the Jules Stein Eye Institute (Principal Investigator), 9/30/05–9/29/12 Bruce Ford and Anne Smith Bundy Foundation, 8/16/11–8/15/12 Faculty | Travis 63
Federico G. Velez, mD Assistant Clinical Professor of Ophthalmology Member of the Jules Stein Eye Institute ReseaRch summaRy Strabismus and Childhood Eye Disorders Dr. Velez’s primary research interest is studying the mechanisms of congenital and acquired forms of strabismus. He has participated in the development of guidelines for preoperative assessment and surgical approaches to patients with convergent (esotropia), divergent (exotropia), and vertical forms of strabismus, and has developed new techniques to treat pediatric patients with eyelid abnormalities and cataracts. Dr. Velez has recently completed studies that apply bioengineering technology to the correction of ocular motility disorders. He has also identified a new ocular motility disorder in patients with the human immunodeficiency virus. 64 Faculty | Velez Public Service Editorial Board Advisory Panel Member, Treatment Strategies—Pediatrics, The Cambridge Research Centre Editorial Board Member, Journal of the American Association of Pediatric Ophthalmology and Strabismus, Journal of the Colombian Society of Ophthalmology, and Video Journal of Ophthalmology Member, American Academy of Ophthalmology, American Association for Pediatric Ophthalmology and Strabismus, Latin American Council of Strabismus, Latin American Pediatric Ophthalmology Society, Colombian Society of Ophthalmology, and Colombian Society of Pediatric Ophthalmology and Strabismus Reviewer for many scientific journals Research Grants Jules Stein Eye Institute: Ocular Motility Disorders in Patients Infected with the Human Immunodeficiency Virus, 6/1/11–5/31/12
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Jules Stein Eye Institute ANNUAL RE
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ii Jules and Doris Stein The legacy
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iv Board of Trustees Board of Trust
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vi Jules Stein Mission Statement Th
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2 Highlights Dear Friends, I am ple
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Institute Brings a Pediatric-Friend
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Honors Each year, as part of their
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Research Research is a key componen
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Adaptive Robotics for Ocular Surger
Page 19 and 20: 17th Annual Vision Science Conferen
Page 21 and 22: Audrey and Jack Skirball continued
Page 23 and 24: The Ahmanson Foundation Awards Gran
Page 25 and 26: Major Gifts over $25,000 American G
Page 27 and 28: Jules Stein Chair in Ophthalmology
Page 29 and 30: Community Outreach Much of the Jule
Page 31 and 32: Vision Education Vision IN-School (
Page 33 and 34: anthony J. aldave, mD Associate Pro
Page 35 and 36: Richard s. Baker, mD Associate Prof
Page 37 and 38: 30 Faculty | Bok Dean Bok, PhD Doll
Page 39 and 40: Richard casey, mD Clinical Professo
Page 41 and 42: Joseph L. Demer, mD, PhD Leonard Ap
Page 43 and 44: Gordon L. Fain, PhD Distinguished P
Page 45 and 46: Joann a. Giaconi, mD Assistant Clin
Page 47 and 48: Robert alan Goldberg, mD Karen and
Page 49 and 50: michael B. Gorin, mD, PhD Harold an
Page 51 and 52: Gary N. holland, mD Jack H. Skirbal
Page 53 and 54: Wayne L. hubbell, PhD Jules Stein P
Page 55 and 56: sherwin J. Isenberg, mD Laraine and
Page 57 and 58: simon K. Law, mD, PharmD Associate
Page 59 and 60: colin a. mccannel, mD Associate Pro
Page 61 and 62: Kevin m. miller, mD Kolokotrones Pr
Page 63 and 64: Kouros Nouri-mahdavi, mD, msc Assis
Page 65 and 66: stacy L. Pineles, mD Assistant Prof
Page 67 and 68: David sarraf, mD Associate Clinical
Page 69: hui sun, PhD Associate Professor of
Page 73 and 74: David s. Williams, PhD Jules and Do
Page 75 and 76: 68 Faculty INsTITuTe memBeRs BaseD
Page 77 and 78: 70 Faculty PROFessIONaL ReseaRch se
Page 79 and 80: 72 Faculty michael D. Olson, OD, Ph
Page 81 and 82: 74 Faculty Vicki chan, mD Associate
Page 84 and 85: Programs
Page 86 and 87: Nearly all the evaluation, diagnosi
Page 88 and 89: Diabetic Eye Disease and Retinal Va
Page 90 and 91: Orbital Disease Center The Orbital
Page 92 and 93: Ophthalmic Photography Clinical Lab
Page 94 and 95: Didactic Education Residents receiv
Page 96 and 97: Fellowship in Cornea-External Ocula
Page 98 and 99: Fellowship in Vitreoretinal Disease
Page 100 and 101: Appendices
Page 102 and 103: Assistant Clinical Professor of Oph
Page 104 and 105: Educational Offerings Ophthalmology
Page 106 and 107: Research Contracts and Grants Fisca
Page 108 and 109: Longitudinal Studies of Ocular Comp
Page 110 and 111: Biochemical and Genetic Analysis of
Page 112 and 113: Age-Related Eye Disease Study II Em
Page 114 and 115: Corneal Endothelial Cell Changes in
Page 116 and 117: Genetics of Age-Related Maculopathy
Page 118 and 119: PET/CT Imaging for Early Detection
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Publications of the Full-Time Facul
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Li X, Bykhovskaya Y, Haritunians T,
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Kalyani PS, Holland GN, Fawzi AA, A
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Dean AW, Glasgow BJ. Mass spectrome
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Appendices | Publications of the Fu
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The emblem of the Jules Stein Eye I
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