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Debora B. Farber, PhD, DPhhc Karl Kirchgessner Professor of Ophthalmology Distinguished Professor of Ophthalmology Member of the Jules Stein Eye Institute Member of the Brain Research Institute Member of the Molecular Biology Institute ReseaRch summaRy Retinal Biochemistry, Molecular Biology, and Genetics of Retinal Degenerations Dr. Farber’s research focuses on the isolation and characterization of genes involved in inherited retinal diseases. Her team has cloned several genes encoding enzymes and proteins that play a key role in vision, including the β-PDE gene, that leads to blindness in mice and dogs, and causes one type of autosomal recessive retinitis pigmentosa (arRP) (utilizing gene therapy methods, they rescued mice photoreceptors by delivering the normal gene to these cells); RP1 (responsible for a type of autosomal dominant RP); the gene causing disease in the rd7 mouse—a model for Enhanced S-Cone Syndrome; the β-transducin gene, disrupted in the Rd4 mouse, another model of retinal disease; and the mouse homologue of the gene causing X-linked juvenile retinochisis (Xlrs1). Dr. Farber’s group is also working on the mechanisms that regulate transcription and expression of retinal genes. They found that the transcription factor SP4 controls the activity of the β-PDE promoter and that mutations in both SP4 and β-transducin cause digenic arRP and cone-rod dystrophy (arCRD). Other projects include the identification of cone genes (mutations in 7R and ZBED4 cause arRP and arCRD); the characterization of animal models of ocular albinism, which are affected with permanent visual impairment; and the study of microvesicles released by mouse embryonic stem cells that transfer RNA or protein to other cells, in vitro. Public Service Scientific Advisory Board Member, the Foundation Fighting Blindness; the Center for Vision Research, State University of New York at Syracuse; the Vision of Children Foundation; and an Advisor for the Canadian Retinitis Pigmentosa Foundation Editorial Board Member, Molecular Vision; The Open Ophthalmology Journal; Journal of Ocular Biology, Diseases, and Informatics; and Stem Cells and Cloning Advances and Applications Reviewer for many scientific journals Research Grants National Eye Institute: Molecular Mechanisms in Retinal Degeneration, 7/1/06–11/30/12 Hope for Vision: Characterization of the Interaction Between ZBED4, a Novel Retinal Protein and SAFB1, 11/1/09–10/31/11 Foundation Fighting Blindness: Clinical and Genetic Characterization of Stargardt and Stargardt-Like Macular Dystrophies: The Potential Role of AMD Risk Factors on the Severity and Progression of These Macular Dystrophies (P.I. Michael Gorin and other investigators), 6/1/11–6/30/13 Faculty | Farber 37
Joann a. Giaconi, mD Assistant Clinical Professor of Ophthalmology Member of the Jules Stein Eye Institute ReseaRch summaRy Glaucoma Dr. Giaconi’s research focuses on the treatment of glaucoma and the effects of glaucoma surgery on the cornea and vision. She is currently working on a project examining the overtreatment or undertreatment of glaucoma in the veteran population. She is also enrolling patients in two clinical studies at the Jules Stein Eye Institute. One study is examining the effect of various glaucoma surgeries on the corneal endothelium, which is the layer of cells that keeps the cornea clear, and the other is investigating the postoperative eye pressure course following Ahmed valve implant surgery. 38 Faculty | Giaconi Public Service Member, Glaucoma Panel, American Academy of Ophthalmology Knowledge Base Development Project Secretary, Women in Ophthalmology President, Los Angeles Society of Ophthalmology Member, American Academy of Ophthalmology Liaisons Committee Volunteer, Eye Care America Reviewer for many scientific journals Research Grants American Glaucoma Society: Evaluation of Evidence-Based Glaucoma Practices at the VA, 9/1/10–8/31/12
Page 1 and 2: Jules Stein Eye Institute ANNUAL RE
Page 3 and 4: ii Jules and Doris Stein The legacy
Page 5 and 6: iv Board of Trustees Board of Trust
Page 7 and 8: vi Jules Stein Mission Statement Th
Page 9 and 10: 2 Highlights Dear Friends, I am ple
Page 11 and 12: Institute Brings a Pediatric-Friend
Page 13 and 14: Honors Each year, as part of their
Page 15 and 16: Research Research is a key componen
Page 17 and 18: Adaptive Robotics for Ocular Surger
Page 19 and 20: 17th Annual Vision Science Conferen
Page 21 and 22: Audrey and Jack Skirball continued
Page 23 and 24: The Ahmanson Foundation Awards Gran
Page 25 and 26: Major Gifts over $25,000 American G
Page 27 and 28: Jules Stein Chair in Ophthalmology
Page 29 and 30: Community Outreach Much of the Jule
Page 31 and 32: Vision Education Vision IN-School (
Page 33 and 34: anthony J. aldave, mD Associate Pro
Page 35 and 36: Richard s. Baker, mD Associate Prof
Page 37 and 38: 30 Faculty | Bok Dean Bok, PhD Doll
Page 39 and 40: Richard casey, mD Clinical Professo
Page 41 and 42: Joseph L. Demer, mD, PhD Leonard Ap
Page 43: Gordon L. Fain, PhD Distinguished P
Page 47 and 48: Robert alan Goldberg, mD Karen and
Page 49 and 50: michael B. Gorin, mD, PhD Harold an
Page 51 and 52: Gary N. holland, mD Jack H. Skirbal
Page 53 and 54: Wayne L. hubbell, PhD Jules Stein P
Page 55 and 56: sherwin J. Isenberg, mD Laraine and
Page 57 and 58: simon K. Law, mD, PharmD Associate
Page 59 and 60: colin a. mccannel, mD Associate Pro
Page 61 and 62: Kevin m. miller, mD Kolokotrones Pr
Page 63 and 64: Kouros Nouri-mahdavi, mD, msc Assis
Page 65 and 66: stacy L. Pineles, mD Assistant Prof
Page 67 and 68: David sarraf, mD Associate Clinical
Page 69 and 70: hui sun, PhD Associate Professor of
Page 71 and 72: Federico G. Velez, mD Assistant Cli
Page 73 and 74: David s. Williams, PhD Jules and Do
Page 75 and 76: 68 Faculty INsTITuTe memBeRs BaseD
Page 77 and 78: 70 Faculty PROFessIONaL ReseaRch se
Page 79 and 80: 72 Faculty michael D. Olson, OD, Ph
Page 81 and 82: 74 Faculty Vicki chan, mD Associate
Page 84 and 85: Programs
Page 86 and 87: Nearly all the evaluation, diagnosi
Page 88 and 89: Diabetic Eye Disease and Retinal Va
Page 90 and 91: Orbital Disease Center The Orbital
Page 92 and 93: Ophthalmic Photography Clinical Lab
Page 94 and 95:
Didactic Education Residents receiv
Page 96 and 97:
Fellowship in Cornea-External Ocula
Page 98 and 99:
Fellowship in Vitreoretinal Disease
Page 100 and 101:
Appendices
Page 102 and 103:
Assistant Clinical Professor of Oph
Page 104 and 105:
Educational Offerings Ophthalmology
Page 106 and 107:
Research Contracts and Grants Fisca
Page 108 and 109:
Longitudinal Studies of Ocular Comp
Page 110 and 111:
Biochemical and Genetic Analysis of
Page 112 and 113:
Age-Related Eye Disease Study II Em
Page 114 and 115:
Corneal Endothelial Cell Changes in
Page 116 and 117:
Genetics of Age-Related Maculopathy
Page 118 and 119:
PET/CT Imaging for Early Detection
Page 120 and 121:
Publications of the Full-Time Facul
Page 122 and 123:
Li X, Bykhovskaya Y, Haritunians T,
Page 124 and 125:
Kalyani PS, Holland GN, Fawzi AA, A
Page 126 and 127:
Dean AW, Glasgow BJ. Mass spectrome
Page 128 and 129:
Appendices | Publications of the Fu
Page 130 and 131:
The emblem of the Jules Stein Eye I
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