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Computational tools and Interoperability in Comparative ... - CBS

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74 Tools for Comparison of<br />

Bacterial Genomes<br />

T. M. Wassenaar 1,2 . T. T. B<strong>in</strong>newies 1,3 . P. F. Hall<strong>in</strong> 1 . D. W. Ussery 1, *<br />

1<br />

Center for Biological Sequence Analysis, Technical University of<br />

Denmark, Kgs. Lyngby, Denmark<br />

*dave@cbs.dtv.dk<br />

2<br />

Molecular Microbiology <strong>and</strong> Genomics Consultants, Zotzenheim,<br />

Germany<br />

3<br />

Roche Diagnostics Ltd., Advanced Systems Group, Global Platforms &<br />

Support, Rotkreuz, Switzerl<strong>and</strong><br />

1 Introduction . . . . . . ..................................................................4314<br />

2 Genomic DNA Sequence Comparisons . ...........................................4314<br />

3 Visualization of Genomic Data: The Genome Atlas ..............................4317<br />

4 Whole Genome Alignment Methods . . . . ...........................................4319<br />

5 Compar<strong>in</strong>g the Cod<strong>in</strong>g Fraction of Genomes . . . . . . . . ..............................4321<br />

6 Codon Usage Comparisons . . . . .....................................................4322<br />

7 Prote<strong>in</strong> Sequence Comparisons . . . . . . . . . ...........................................4322<br />

8 Gene Synteny <strong>and</strong> Genome Isl<strong>and</strong>s . . . . . ...........................................4325<br />

9 M<strong>in</strong>imal Information About a Genome Sequence . . . ..............................4325<br />

10 Research Needs . . . ..................................................................4325<br />

K. N. Timmis (ed.), H<strong>and</strong>book of Hydrocarbon <strong>and</strong> Lipid Microbiology, DOI 10.1007/978-3-540-77587-4_337,<br />

# Spr<strong>in</strong>ger-Verlag Berl<strong>in</strong> Heidelberg, 2010

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