BIBLIOGRAPHY Q. J<strong>in</strong>, Z. Yuan, J. Xu, Y. Wang, Y. Shen, W. Lu, J. Wang, H. Liu, J. Yang, F. Yang, X. Zhang, J. Zhang, G. Yang, H. Wu, D. Qu, J. Dong, L. Sun, Y. Xue, A. Zhao, Y. Gao, J. Zhu, B. Kan, K. D<strong>in</strong>g, S. Chen, H. Cheng, Z. Yao, B. He, R. Chen, D. Ma, B. Qiang, Y. Wen, Y. Hou, & J. Yu (2002). ‘Genome sequence of Shigella flexneri 2a: <strong>in</strong>sights <strong>in</strong>to pathogenicitythrough comparison with genomes of Escherichia coli k12 <strong>and</strong> o157.’ Nucleic Acids Res 30:4432–41. T. J. Johnson, S. Kariyawasam, Y. Wannemuehler, P. Mangiamele, S. J. Johnson, C. Doetkott, J. A. Skyberg, A. M. Lynne, J. R. Johnson, & L. K. Nolan (2007). ‘The genome sequence of avian pathogenic Escherichia coli stra<strong>in</strong> o1:k1:h7shares strong similarities with human extra<strong>in</strong>test<strong>in</strong>al pathogenic e. coligenomes.’ J Bacteriol 189:3228–36. J. Kyte & R. F. Doolittle (1982). ‘A simple method for display<strong>in</strong>g the hydropathic character of a prote<strong>in</strong>.’ J Mol Biol 157:105–32. K. Lagesen, P. Hall<strong>in</strong>, E. A. Rodl<strong>and</strong>, H.-H. Staerfeldt, T. Rognes, & D. W. Ussery (2007). ‘RNAmmer: consistent <strong>and</strong> rapid annotation of ribosomal rna genes.’ Nucleic Acids Res 35:3100–8. T. S. Larsen & A. Krogh (2003). ‘EasyGene–a prokaryotic gene f<strong>in</strong>der that ranks ORFs by statistical significance.’ BMC Bio<strong>in</strong>formatics 4:21. T. Lefebure & M. J. Stanhope (2007). ‘Evolution of the core <strong>and</strong> pan–genome of Streptococcus: positive selection, recomb<strong>in</strong>ation, <strong>and</strong> genome composition.’ Genome Biol 8:R71. X. Liao, T. Y<strong>in</strong>g, H. Wang, J. Wang, Z. Shi, E. Feng, K. Wei, Y. Wang, X. Zhang, L. Huang, G. Su, & P. Huang (2003). ‘A two–dimensional proteome map of Shigella flexneri.’ Electrophoresis 24:2864–82. B. Liebig & R. Wagner (1995). ‘Effects of different growth conditions on the <strong>in</strong> vivo activity of thet<strong>and</strong>em Escherichia coli ribosomal rna promoters p1 <strong>and</strong> p2.’ Mol Gen Genet 249:328–35. D. Lim & N. C. J. Strynadka (2002). ‘Structural basis for the beta lactam resistance of pbp2a from methicill<strong>in</strong>–resistant Staphylococcus aureus.’ Nat Struct Biol 9:870–6. T. M. Lowe & S. R. Eddy (1997). ‘tRNAscan–se: a program for improved detection of transfer rna genes <strong>in</strong>genomic sequence.’ Nucleic Acids Res 25:955–64. J. P. McCutcheon, B. R. McDonald, & N. A. Moran (2009). ‘Orig<strong>in</strong> of an alternative genetic code <strong>in</strong> the extremely small <strong>and</strong> gc–rich genome of a bacterial symbiont.’ PLoS Genet 5:e1000565. C. E. McEwan, D. Gatherer, & N. R. McEwan (1998). ‘Nitrogen–fix<strong>in</strong>g aerobic bacteria have higher genomic gc content than non–fix<strong>in</strong>g species with<strong>in</strong> the same genus.’ Hereditas 128:173–8. W. G. Miller, C. T. Parker, M. Rubenfield, G. L. Mendz, M. M. S. M. Wosten, D. W. Ussery, J. F. Stolz, T. T. B<strong>in</strong>newies, P. F. Hall<strong>in</strong>, G. Wang, J. A. Malek, A. Rogos<strong>in</strong>, L. H. Stanker, & R. E. M<strong>and</strong>rell (2007). ‘The complete genome sequence <strong>and</strong> analysis of the epsilonproteobacteriumArcobacter butzleri.’ PLoS One 2:e1358. H. D. Murray & R. L. Gourse (2004). ‘Unique roles of the rrn p2 rrna promoters <strong>in</strong> Escherichia coli.’ Mol Microbiol 52:1375–87. 177
BIBLIOGRAPHY A. Nakabachi, A. Yamashita, H. Toh, H. Ishikawa, H. E. Dunbar, N. A. Moran, & M. Hattori (2006). ‘The 160–kilobase genome of the bacterial endosymbiont Carsonella.’ Science 314:267. C. Ong, C. H. Ooi, D. Wang, H. Chong, K. C. Ng, F. Rodrigues, M. A. Lee, & P. Tan (2004). ‘Patterns of large–scale genomic variation <strong>in</strong> virulent <strong>and</strong> avirulentBurkholderia species.’ Genome Res 14:2295–307. J. Parkhill, B. W. Wren, K. Mungall, J. M. Ketley, C. Churcher, D. Basham, T. Chill<strong>in</strong>gworth, R. M. Davies, T. Feltwell, S. Holroyd, K. Jagels, A. V. Karlyshev, S. Moule, M. J. Pallen, C. W. Penn, M. A. Quail, M. A. Raj<strong>and</strong>ream, K. M. Rutherford, A. H. van Vliet, S. Whitehead, & B. G. Barrell (2000). ‘The genome sequence of the food–borne pathogen Campylobacter jejunireveals hypervariable sequences.’ Nature 403:665–8. A. G. Pedersen, L. J. Jensen, S. Brunak, H. H. Staerfeldt, & D. W. Ussery (2000). ‘A dna structural atlas for Escherichia coli.’ J Mol Biol 299:907–30. V. Perez-Brocal, R. Gil, S. Ramos, A. Lamelas, M. Postigo, J. M. Michelena, F. J. Silva, A. Moya, & A. Latorre (2006). ‘A small microbial genome: the end of a long symbiotic relationship?’ Science 314:312–3. N. T. Perna, G. r. Plunkett, V. Burl<strong>and</strong>, B. Mau, J. D. Glasner, D. J. Rose, G. F. Mayhew, P. S. Evans, J. Gregor, H. A. Kirkpatrick, G. Posfai, J. Hackett, S. Kl<strong>in</strong>k, A. Bout<strong>in</strong>, Y. Shao, L. Miller, E. J. Grotbeck, N. W. Davis, A. Lim, E. T. Dimalanta, K. D. Potamousis, J. Apodaca, T. S. Anantharaman, J. L<strong>in</strong>, G. Yen, D. C. Schwartz, R. A. Welch, & F. R. Blattner (2001). ‘Genome sequence of enterohaemorrhagic Escherichia coli o157:h7.’ Nature 409:529–33. O. N. Reva, P. F. Hall<strong>in</strong>, H. Willenbrock, T. Sicheritz-Ponten, B. Tummler, & D. W. Ussery (2008). ‘Global features of the Alcanivorax borkumensis sk2 genome.’ Environ Microbiol 10:614–25. E. P. C. Rocha (2004). ‘Codon usage bias from trna‘s po<strong>in</strong>t of view: redundancy, specialization, <strong>and</strong> efficient decod<strong>in</strong>g for translation optimization.’ Genome Res 14:2279–86. W. Ross, J. Salomon, W. M. Holmes, & R. L. Gourse (1999). ‘Activation of Escherichia coli leuv transcription by fis.’ J Bacteriol 181:3864–8. K. Rutherford, J. Parkhill, J. Crook, T. Horsnell, P. Rice, M. A. Raj<strong>and</strong>ream, & B. Barrell (2000). ‘Artemis: sequence visualization <strong>and</strong> annotation.’ Bio<strong>in</strong>formatics 16:944–5. R. A. Sanford, J. R. Cole, & J. M. Tiedje (2002). ‘Characterization <strong>and</strong> description of Anaeromyxobacter dehalogenans gen. nov., sp. nov., an aryl–halorespir<strong>in</strong>g facultative anaerobic myxobacterium.’ Appl Environ Microbiol 68:893–900. S. C. Satchwell, H. R. Drew, & A. A. Travers (1986). ‘Sequence periodicities <strong>in</strong> chicken nucleosome core dna.’ J Mol Biol 191:659–75. S. Schneiker, O. Perlova, O. Kaiser, K. Gerth, A. Alici, M. O. Altmeyer, D. Bartels, T. Bekel, S. Beyer, E. Bode, H. B. Bode, C. J. Bolten, J. V. Choudhuri, S. Doss, Y. A. Elnakady, B. Frank, L. Gaigalat, A. Goesmann, C. Groeger, F. Gross, L. Jelsbak, L. Jelsbak, J. Kal<strong>in</strong>owski, C. Kegler, T. Knauber, S. Konietzny, M. Kopp, L. Krause, D. Krug, B. L<strong>in</strong>ke, T. Mahmud, R. Mart<strong>in</strong>ez-Arias, A. C. McHardy, M. Merai, F. Meyer, S. Mormann, J. Munoz-Dorado, J. Perez, S. Pradella, S. Rachid, G. Raddatz, F. Rosenau, C. Ruckert, F. Sasse, M. Scharfe, S. C. Schuster, G. Suen, A. Treuner-Lange, G. J. 178
- Page 1 and 2:
Peter Fischer Hallin | 2009 Peter F
- Page 4:
Preface This Ph.D. thesis is writte
- Page 7 and 8:
thesis, the work is just being publ
- Page 9 and 10:
ved at blive publiceret i Standards
- Page 11 and 12:
viii
- Page 13 and 14:
Paper VI [Lagesen K, Hallin P] 1 ,
- Page 15 and 16:
xii
- Page 17 and 18:
3.3.3 Refining E. coli and Shigella
- Page 19 and 20:
xvi
- Page 21 and 22:
xviii 2.17 Pan- and core-genome plo
- Page 24 and 25:
Chapter 1 Introduction Introduction
- Page 26 and 27:
Chapter 2 Comparative Genomics 2.1
- Page 28 and 29:
Comparative Genomics the publicly a
- Page 30 and 31:
Comparative Genomics source CDS tot
- Page 32 and 33:
Comparative Genomics 1 mysql -N -B
- Page 34 and 35:
Listing 2.8: R code to generate a 2
- Page 36 and 37:
1st U C A G U 2nd position C A G 3r
- Page 38 and 39:
1st U C A G U 2nd position C A G 3r
- Page 40 and 41:
Escherichia coli strain K-12, subst
- Page 42 and 43:
Comparative Genomics
- Page 44 and 45:
3M 2.5M 3.5M 2.5M 2M 0M 2M 0.5M B.
- Page 46 and 47:
Streptococcus Escherichia Bacillus
- Page 48 and 49:
2.4 Summary Comparative Genomics Th
- Page 50 and 51:
Comparative Genomics 2.5 Instant in
- Page 52 and 53:
‘ReSourCe is he best online submi
- Page 54 and 55:
up to a total of 41 different E. co
- Page 56 and 57:
Fig. 2 Genes (or segments) from eac
- Page 58 and 59:
Fig. 5 BLASTatlas of Clostridium bo
- Page 60 and 61:
different applications, such as ide
- Page 62 and 63:
1 Comparative Genomics 2.7 Paper II
- Page 64 and 65:
166 literally millions of bacterial
- Page 66 and 67:
168
- Page 68 and 69:
170 resistance genes on mobile gene
- Page 70 and 71:
172 involved in generating diversit
- Page 72 and 73:
174 recipient DNA. A feature observ
- Page 74 and 75:
176 Fig. 5 Genome length distributi
- Page 76 and 77:
178
- Page 78 and 79:
180 reasons why organisms remain un
- Page 80 and 81:
182 A final problem has to do with
- Page 82 and 83:
184 Middendorf B, Hochhut B, Leipol
- Page 84 and 85:
1 Comparative Genomics 2.8 Paper II
- Page 86 and 87:
2 O. N. Reva et al. Fig. 1. Genome
- Page 88 and 89:
4 O. N. Reva et al. decrease of the
- Page 90 and 91:
6 O. N. Reva et al. of which are kn
- Page 92 and 93:
8 O. N. Reva et al. compiled into a
- Page 94 and 95:
10 O. N. Reva et al. encoded by a c
- Page 96 and 97:
12 O. N. Reva et al. systems and ef
- Page 98 and 99:
1 2.9 Paper IV: The origins of Vibr
- Page 100 and 101:
phylogenies based on alternative ho
- Page 102 and 103:
Figure 1 Phylogenetic tree of the 1
- Page 104 and 105:
25000 20000 15000 10000 5000 0 Pan
- Page 106 and 107:
Gap F 2M 2.5M Gap E 875k 750k 625k
- Page 108 and 109:
Table 2 A selection of genes locate
- Page 110 and 111:
Open Access This article is distrib
- Page 112 and 113:
1 Comparative Genomics 2.10 Paper V
- Page 114 and 115:
4314 74 Tools Abstract: Of the plet
- Page 116 and 117:
4316 74 Tools Size distribution of
- Page 118 and 119:
4318 74 Tools Genome atlas Intrinsi
- Page 120 and 121:
4320 74 Tools Genome atlas Intrinsi
- Page 122 and 123:
4322 74 Tools for Comparison of Bac
- Page 124 and 125:
4324 74 Tools for Comparison of Bac
- Page 126 and 127:
4326 74 Tools information, as genet
- Page 128 and 129:
Chapter 3 rRNA operons and promoter
- Page 130 and 131:
tuB murI Fis III Fis II Fis I UP -3
- Page 132 and 133:
Bits 2.0 1.5 1.0 0.5 0.0 Bits 2.0 1
- Page 134 and 135:
RNA operons and promoter analysis O
- Page 136 and 137:
Bits 2.0 1.5 1.0 0.5 0.0 Bits T A T
- Page 138 and 139:
Code Meaning Example C Coding CCCCC
- Page 140 and 141:
RNA operons and promoter analysis 3
- Page 142 and 143:
P2 -10 -35 UP P1 -10 -35 UP FIS FIS
- Page 144 and 145:
1 rRNA operons and promoter analysi
- Page 146 and 147:
Using HMMs also simplifies the use
- Page 148 and 149:
Information content Information con
- Page 150 and 151: of the annotation. Some of the majo
- Page 152 and 153: where match states stop around 10 c
- Page 154 and 155: 1 rRNA operons and promoter analysi
- Page 156 and 157: synthesis in flow cells to simultan
- Page 158 and 159: Read absence. A boolean where ‘on
- Page 160 and 161: Hallin, et al. Figure 4 | The dataf
- Page 162 and 163: Genome homology: Comparing multiple
- Page 164 and 165: ing platform-‐independent Java
- Page 166 and 167: 34. Wang H, Noordewier M, Benham CJ
- Page 168 and 169: Chapter 4 Web Services and Interope
- Page 170 and 171: Web Services and Interoperability i
- Page 172 and 173: Web Services and Interoperability i
- Page 174 and 175: Web Services and Interoperability i
- Page 176 and 177: Web Services and Interoperability i
- Page 178 and 179: Chapter 5 Conclusion and perspectiv
- Page 180 and 181: Appendix A Appendix: Workshops, tea
- Page 182 and 183: Appendix B Appendix: Ph.D. study pl
- Page 184 and 185: Danmarks Tekniske Universitet AFI,
- Page 186 and 187: Danmarks Tekniske Universitet AFI,
- Page 188 and 189: Appendix C Appendix: Courses C.1 Gl
- Page 190 and 191: D.2 Sample output from queryGenomes
- Page 192 and 193: Appendix: Software 13 w a r n " $ o
- Page 194 and 195: Appendix: Software 109 m y ( $ m i
- Page 196 and 197: Appendix: Software 25 [ ] A l t e r
- Page 198 and 199: BIBLIOGRAPHY J. Rogers, P. F. Stadl
- Page 202 and 203: BIBLIOGRAPHY Velicer, F.-J. Vorholt