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may be made of gold, silver, Fe 2 O 3 , metal alloys, etc. while the core is surrounded by a functional ized linker or ligands (aliphatic chain, PEG, dextran or mixture thereof) to increase drug delivery specifity (Parak, W. J. Chem. Soc. Rev,, 2008, 37, 1896 - 1908). Carbon nanotubes belong to the family of fullerenes and are formed of coaxial graphite sheets rolled up into cylinders, in the form of single (one graphite sheet) or multi-walled concentric nanotubes. Carbon nanotubes can also be rendered water soluble by surface functionalization (Pilizu, S. et a/., J. Nanosci. Nanotechnol., 2006, 6, 1883-1904). Suitable polymers, which may be used as the Z scaffold comprise both artificial and natural polymers. For instance, artificial polymers include poly(ethylene glycol)(PEG), poly(amidoamine), poly(propyleneamine) (POPAM), poly(propyleneimine) (PPI), etc., while natural polymers include peptides, oligopeptides and sugars, such as, for instance, dextran, cellulose, etc. Other suitable scaffolds may be aromatic based, ethylene diamine based or propylene diamine based. In particular, in a preferred embodiment, the Z scaffold is a polyester dendron based on 2,2'-bis(methoxyol)propanoic acid (bis-MPA), such as the dendron or is a first or second or higher generation dendrimer based on 2,2'- bis(methoxyol)propanoic acid (bis-MPA) such as
Alternatively, Z is a poly(amidoamine) (PAMAM) dendron or dendrimer (see, for instance, at Fig. 13) Within the compounds of formula (I), the one wherein when the dendrimer is the third generation dendrimer based on 2,2'-bis(methoxyol)propanoic acid (bis-MPA): and the X moiety is is excluded from the present invention.
Page 1 and 2: (12) INTERNATIONAL APPLICATION PUBL
Page 3 and 4: mannose disaccharide (Manα1-2Man),
Page 5 and 6: It is a forth object of the inventi
Page 7 and 8: M' is a saccharidic or pseudo-sacch
Page 9 and 10: wherein Q and n are above disclosed
Page 12 and 13: wherein R is as above disclosed,
Page 16 and 17: Within the compound of formula (I)
Page 18 and 19: wherein R and R 2 are as above repo
Page 20 and 21: through the Y linker and n is 1 to
Page 22 and 23: and (12a) 12b. As per a third aspec
Page 24 and 25: H wherein Q is selected from — N
Page 26 and 27: According to a second object of the
Page 28 and 29: wherein aj is 32 and J is a third g
Page 30 and 31: eactions requiring anhydrous condit
Page 32 and 33: To a solution of the silylmannopyra
Page 34 and 35: 3H, CH 3 CO), 1.99 (s, 3H, CH 3 CO)
Page 36 and 37: To a solution of the compound 9 (12
Page 38 and 39: (C2 D ), 70.36 (C6 M ), 70.01 (C6 M
Page 40 and 41: EXAMPLE 2 Synthesis of compound 12a
Page 42 and 43: 13 C-NMR (100 MHz, D2 O) δ (ppm):
Page 44 and 45: (the R5 tropic laboratory-adapted s
Page 46 and 47: derived from 1 (see above); G3Man32
Page 48 and 49: CLAIMS: 1 A compound of general for
Page 50: OCH 3 ), hydroxymethyl (-CH 2 OH),
Page 53 and 54: alkyl chain, C1-C8 linear or branch
Page 55 and 56: 7 . A compound having the general f
Page 57 and 58: H wherein Q is selected from — N
Page 59: or methyl substituted 1,3-thiazole;
Page 62 and 63: wherein R 2 may be hydroxyl (-0H),
Page 64 and 65:
12. A compound according to claim 1
Page 66:
or methyl substituted 1,3-thiazole;
Page 82 and 83:
INTERNATIONAL SEARCH REPORT C(Conti
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W0 2011/000721 A1 I||||||||||||||||||||||||||||||||||||||||||||||||||||||||| - Questel

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