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W0 2011/000721 A1 I||||||||||||||||||||||||||||||||||||||||||||||||||||||||| - Questel

W0 2011/000721 A1 I||||||||||||||||||||||||||||||||||||||||||||||||||||||||| - Questel

W0 2011/000721 A1 I||||||||||||||||||||||||||||||||||||||||||||||||||||||||| - Questel

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wherein aj is 32 and J is a third generation 2,2'-bis(methoxyol)propanoic acid<br />

(bis-MPA) based dendrimerforthe treatment and/or prevention of HIV (Human<br />

Immunodeficiency Virus), Dengue, Ebola, Hepatitis C, SARS and<br />

Mycobacterium tuberculosis infections.<br />

For the purposes of a forth embodiment of the present invention, the disclosed<br />

compounds may be formulated in a suitable effective amount together with<br />

suitable pharmaceutically acceptable excipients according to the specific form<br />

of administration and/or additives selected in the group comprising diluent,<br />

solvents, bulking agents, fillers, reological modifier, stabilizers, binders,<br />

lubricants, disintegrant, preservatives, pH adjusting agents, buffers,<br />

antioxidant, chelating agents, plasticizer, polymers, emulsifiers, edulcorants,<br />

flavoring agents, alone or in combination thereof, to give a pharmaceutical<br />

preparation as per a further embodiment of the invention.<br />

The preparations of the present invention may be administered by various<br />

route of administration, such as, for instance, oral, including buccal or<br />

sublingual administration; rectal; nasal; transdermal; vaginal; or parenteral,<br />

including subcutaneous, intramuscular, intravenous or intradermal route or<br />

topically.<br />

In particular, for oral administration, they can be prepared in the form of hard or<br />

soft capsules, tables, powders or granules; solutions syrups or suspensions in<br />

aqueous or non-aqueous liquids; edible foams or whips; or either oil-in-water or<br />

water-in-oil liquid emulsions. Alternatively, for nasal administration sprays or

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