W0 2011/000721 A1 I||||||||||||||||||||||||||||||||||||||||||||||||||||||||| - Questel

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CLAIMS: 1 A compound of general formula (I): [X-Y] 2 -Z (I) wherein X is a saccharidic or pseudosaccharidic unit of formula M-D-M', wherein M' is of formula D is of formula wherein R 2 may be hydroxyl (-OH), alkoxy (-0-R'), wherein R' is a C1-C8 linear or branched, saturated or unsaturated alkyl chain and is preferably a methoxy group (-OCH 3 ), or R 2 is -N-R 3 2 , wherein each R3 may be independently H, a C1-C8 linear or branched, saturated or unsaturated alkyl chain, optionally substituted with an A group, wherein the A group is a C3-C6 saturated or partially unsaturated cyclic- or heterocyclic ring or a C5-C6 aromatic or heteroaromatic ring, optionally substituted at any available position with one or more of hydroxyl (-OH), C1-C8 linear or branched, saturated or unsaturated alkyl chain, C1-C8 linear or branched, saturated or unsaturated alkoxy carbon chain, hydroxyalkyl, such as hydroxymethyl (-CH 2 OH), amino (-NH 2 ), thiol (- M
SH), nitro (-NO 2 ), carboxy (-C00H); or R 3 is an A group as above defined; and M is -(O-CH 2 -CH 2 -)n-Q or -(O-CH 2 -CH 2 -CH 2 -)n-Q or H wherein Q is selected from — N — , -S- or -O- and it is linked to the scaffold Z through a Y linker and n is 1 to 3 ; the Y linker is selected from an amino acidic residue or a succinic acid or diglycolic acid residue, Z is a scaffold selected from liposomes, nanoparticles, polymers, dendrimers or dendrons and az is the functionality of said scaffold Z and it is comprised between 1 and 150, provided that when in the X moiety R 1 is H, R 2 is methoxy, M is -(0-CH 2 -CH 2 - ) n -Q wherein n is 1 and Y is a succinic acid residue, the Z scaffold is not the dendrimer of formula 2 . A compound of formula (I) according to claim 1, wherein R 2 is methoxy or is -NHR 3 , wherein R 3 is an A group selected among cyclopropan, cyclohexil, phenyl, benzyl or benzyl meta or para substituted with methoxy (-OCH 3 ), nitro (-NO 2 ), carboxy (-COOH), methylester (-COOCH 3 ), methyl (-CH 3 ), methoxy (-
Page 1 and 2: (12) INTERNATIONAL APPLICATION PUBL
Page 3 and 4: mannose disaccharide (Manα1-2Man),
Page 5 and 6: It is a forth object of the inventi
Page 7 and 8: M' is a saccharidic or pseudo-sacch
Page 9 and 10: wherein Q and n are above disclosed
Page 12 and 13: wherein R is as above disclosed,
Page 14 and 15: may be made of gold, silver, Fe 2 O
Page 16 and 17: Within the compound of formula (I)
Page 18 and 19: wherein R and R 2 are as above repo
Page 20 and 21: through the Y linker and n is 1 to
Page 22 and 23: and (12a) 12b. As per a third aspec
Page 24 and 25: H wherein Q is selected from — N
Page 26 and 27: According to a second object of the
Page 28 and 29: wherein aj is 32 and J is a third g
Page 30 and 31: eactions requiring anhydrous condit
Page 32 and 33: To a solution of the silylmannopyra
Page 34 and 35: 3H, CH 3 CO), 1.99 (s, 3H, CH 3 CO)
Page 36 and 37: To a solution of the compound 9 (12
Page 38 and 39: (C2 D ), 70.36 (C6 M ), 70.01 (C6 M
Page 40 and 41: EXAMPLE 2 Synthesis of compound 12a
Page 42 and 43: 13 C-NMR (100 MHz, D2 O) δ (ppm):
Page 44 and 45: (the R5 tropic laboratory-adapted s
Page 46 and 47: derived from 1 (see above); G3Man32
Page 50: OCH 3 ), hydroxymethyl (-CH 2 OH),
Page 53 and 54: alkyl chain, C1-C8 linear or branch
Page 55 and 56: 7 . A compound having the general f
Page 57 and 58: H wherein Q is selected from — N
Page 59: or methyl substituted 1,3-thiazole;
Page 62 and 63: wherein R 2 may be hydroxyl (-0H),
Page 64 and 65: 12. A compound according to claim 1
Page 66: or methyl substituted 1,3-thiazole;
Page 82 and 83: INTERNATIONAL SEARCH REPORT C(Conti

W0 2011/000721 A1 I||||||||||||||||||||||||||||||||||||||||||||||||||||||||| - Questel

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