THIS WEEK IN

More documents

Recommendations

Info

special advertising section with the pathways the genes are involved with,” Baharloo explains. “It deconvolutes the various pathways.” To update pathways, a group at GeneGo combs through the peer-reviewed literature. “We’ll update significant changes instantly and minor ones shortly,” Baharloo says. Affymetrix, meanwhile, recently launched a GeneChip Compatible Software Partners Program that provides users of microarrays with a broad spectrum of integrated solutions for biomedical research and development. Software and Hardware Agilent’s Silicon Genetics unit specializes in software for expression data analysis and management. Its GeneSpring software product is a powerful visualization and analysis solution, designed for use with genomic expression data from virtually any source, that can display and analyze large datasets on a typical desktop computer. “GeneSpring is the center of our code base. We’re aiming to add new applications and uses for any high throughput technologies,” Stockton says “Data generated from many different types of microarray applications tend to be useful in the same experiment,” Cole adds. “So it’s becoming important to leverage many pieces of microarray data. We’re working on tools to do that in the GeneSpring platform.” Microarray applications are clearly pressing the limits of conventional computing power. Hardware companies such as Apple, HP, and IBM are working on ways to obtain more power from existing computers, to develop more powerful computers, and to devise more capable software. “We are doing our own research and supporting research at academic institutions,” HP’s Gabashvili says. “For real-time results you need good middleware, which we are designing. Ours is unique in that our customers can decide just what they want.” The firm also takes a highly customized approach to bioinformatics, aiming to determine the optimum high performance architectures for its customers’ needs. “Every bioinformatics company says that it offers customized software,” Gabashvili says. “But we are supporting the IEEE standardization initiative for bioinformatics – in particular in microarrays – to increase productivity in the field.” HP also encourages a move of microarraying into the diagnostic arena. “One of our collaborators, Harvard Partners Centers for Genetics and Genomics, is using microarrays to diagnose certain diseases such as deafness, particularly in babies,” Gabashvili says. “And another partner, at the Biomedical Engineering department of the Georgia Institute of Technology and Emory University, is integrating the microarray technology with bionanotechnology in cancer research for uses such as early detection, diagnosis, prognosis, and therapeutics.” FEATURED COMPANIES Affymetrix, DNA microarrays, http://www.affymetrix.com Agilent Technologies, lab-on-a-chip systems, http://www.agilent.com Apple Computer, Inc., computers and operating systems, http://www.apple.com Association of Biomolecular Resource Facilities (ABRF), scientific society, http://www.abrf.org BD Biosciences Clontech, nylon membrane arrays, http://www.clontech.com Columbus Children's Research Institute, nonprofit research institute, http://www.ccri.net GE Healthcare, products for microarray fabrication, http://www.gehealthcare.com GeneGo, Inc., bioinformatics software, http://www.genego.com Georgia Institute of Technology, university, http://www.gatech.edu >> advances in: Biochips Diagnostic Applications in View Roche Molecular Systems has taken that movement a stage further. The U.S. Food and Drug Administration has cleared its first microarray based test, the AmpliChip CYP450 Test, powered by Affymetrix microarray technology, for diagnostic use in the United States. “The test detects variations in the CYP2D6 and CYP2C19 genes, which play a primary role in the metabolism of many widely prescribed drugs,” Koch explains. “The test also provides a predicted phenotype – that is, poor, intermediate, extensive, or ultrarapid metabolizer.” That represents just a start. “We are continuing to develop other innovative clinical diagnostic AmpliChip tests based on the Affymetrix highdensity oligonucleotide microarray platform,” Koch says. “Several other companies are also working on developing microarrays for diagnostic use, so one might say a trend is beginning.” Microarrays have proven their utility for research in several areas, including expression profiling, SNP analysis, and tumor sub-typing. The data from these devices just keeps on coming as microarrays gain popularity with researchers worldwide. And as progress continues in developing standards and more application-specific arrays come to market, these new tools will become increasingly useful in revealing more and more scientific data from less and less sample. Peter Gwynne (pgwynne767@aol.com) is a freelance science writer based on Cape Cod, Massachusetts, U.S.A. Gary Heebner (gheebner@cell-associates.com) is a marketing consultant with Cell Associates in St. Louis, Missouri, U.S.A. Harvard Partners Center for Genetics and Genomics, research institute, http://www.hpcgg.org Hewlett-Packard, computers and operating systems, http://www.hp.com Hitachi Genetic Systems/MiraiBio, products for microarray fabrication, http://www.miraibio.com IBM Healthcare and Life Sciences, computers and operating systems, http://www.ibm.com Invitrogen Corporation, scientific software, http://www.invitrogen.com LION Bioscience AG [Germany], bioinformatics software, http://www.lionbioscience.com Massachusetts Institute of Technology (MIT), university, http://www.mit.edu Millipore Corporation, nylon membrane arrays, http://www.millipore.com Molecular Devices, image detection systems, http://www.moldev.com MP Biomedicals, radiolabeled biochemical, http://www.mpbio.com PerkinElmer Life and Analytical Sciences, radiolabeled biochemical, http://las.perkinelmer.com Premier BioSoft, bioinformatics software, http://www.premierbiosoft.com Roche Molecular Diagnostics, diagnostic kits and reagents, http://www.roche.com Sigma-Aldrich Corporation, products for microarray fabrication, http://www.sigma-aldrich.com Spotfire, Inc., bioinformatics software, http://www.spotfire.com Telechem International, Inc., bioinformatics software, http://www.arrayit.com U.S. Food and Drug Administration (FDA), government organization, http://www.fda.gov Science’s GetInfo – products and more > science.labvelocity.com 1595
1596 Classified Advertising Thomas Edison 1847–1931 Founder of Science For full advertising details, go to www.sciencecareers.org and click on How to Advertise, or call one of our representatives. United States & Canada E-mail: advertise@sciencecareers.org Fax: 202-289-6742 jill downing (CT, DE, DC, FL, GA, MD, ME, MA, NH, NJ, NY, NC, PA, RI, SC, VT, VA) Phone: 631-580-2445 kristine von zedlitz (AK, AZ, CA, CO, HI, ID, IA, KS, MT, NE, NV, NM, ND, OR, SD, TX, UT, WA, WY) Phone: 415-956-2531 kathleen clark Employment: AR, IL, LA, MN, MO, OK, WI, Canada; Graduate Programs; Meetings & Announcements (U.S., Canada, Caribbean, Central and South America) Phone: 510-271-8349 emnet tesfaye (Display Ads: AL, IN, KY, MI, MS, OH, TN, WV; Line Ads) Phone: 202-326-6740 gabrielle boguslawski (U.S. Recruitment Advertising Sales Director) Phone: 718-491-1607 Europe & International E-mail: ads@science-int.co.uk Fax: +44 (0) 1223-326-532 tracy holmes Phone: +44 (0) 1223-326-525 helen moroney Phone: +44 (0) 1223-326-528 christina harrison Phone: +44 (0) 1223-326-510 svitlana barnes Phone: +44 (0) 1223-326-527 jason hannaford Phone: +81 (0) 52-789-1860 To subscribe to Science: In U.S./Canada call 202-326-6417 or 1-800-731-4939 In the rest of the world call +44 (0) 1223-326-515 Science makes every effort to screen its ads for offensive and/or discriminatory language in accordance with U.S. and non-U.S. law. Since we are an international journal, you may see ads from non-U.S. countries that request applications from specific demographic groups. Since U.S. law does not apply to other countries we try to accommodate recruiting practices of other countries. However, we encourage our readers to alert us to any ads that they feel are discriminatory or offensive. POSITIONS OPEN FACULTY POSITIONS IN BIOPSYCHOLOGY The University of Chicago The University of Chicago is seeking to fill SENIOR or JUNIOR POSITIONS in biopsychology. Our primary goal is to understand behavior and the mind in relation to biological mechanisms. We construe biological mechanisms to include the interactions among the nervous, endocrine, and immune systems, and we are particularly interested in those who study effects of mental and behavioral processes on biological mechanisms. The Institute for Mind and Biology, housed in a new biopsychological sciences research facility, is dedicated to behavioral studies in animals and humans, with fully accredited animal care facilities and communal research equipment. Ideal candidates are those whose research interests bridge to other strengths in the Department of Psychology, and are enthusiastic about engaging in collaborative transdisciplinary research within a highly interactive research community both inside and outside the Department of Psychology. We invite applications from individuals who primarily study animals and employ an integrative approach incorporating multiple biological mechanisms (e.g., genetic, molecular, neurochemical, hormonal, immune, electrophysiological) that complement their behavioral research. Of particular interest is research in the developmental, emotional, social, and cognitive aspects of psychological processes. Evaluation of applicants will begin November 1, 2005. Applicants should submit curriculum vitae, a conceptual summary of research, a statement of teaching interests/philosophy, representative publications, and three letters of reference. Please send all materials to: Biopsychology Search Committee, 5730 Woodlawn Avenue, Room 101, Chicago, IL 60637. The University of Chicago is an Affirmative Action/Equal Opportunity Employer. UC DAVIS SCHOOL OF MEDICINE Department of Psychiatry and Behavioral Sciences ASSISTANT/ASSOCIATE/FULL PROFES- SOR of psychiatry. The Department of Psychiatry and Behavioral Sciences and the Center for Neuroscience, University of California, Davis, invite applications for a Neuroscientist at the Assistant/ Associate/Full Professor level, to begin July 1, 2006. Specialization within any area of cellular or molecular neuroscience consistent with the broad goals of the Department and Center is open but candidates with backgrounds in the neuropathology of schizophrenia are encouraged to apply, especially if their research can interact productively with existing and developing programs on the neuropathology of major mental illnesses in the School of Medicine. The successful candidate will be expected to demonstrate leadership in their research specialty, obtain extramural funds, and participate in teaching, and University and public service. Candidate will teach graduate students, medical students, and psychiatry residents. Candidates must possess a Ph.D. or M.D. degree. Some clinical responsibilities possible for qualified applicants but not essential. Applicants should send a letter, in response to search #3824, describing their research and teaching interests, curriculum vitae, copies of representative publications, and the names of at least five persons from whom references can be obtained to: Edward G. Jones M.D., Ph.D., Director, Center for Neuroscience and Distinguished Professor of Psychiatry and Behavioral Sciences, 1544 Newton Court, University of California, Davis, CA 95616-8659. All materials must be received by November 30, 2005, to be assured of consideration. The search will continue until the position is filled. The University of California is an Affirmative Action/Equal Opportunity Employer. 2 SEPTEMBER 2005 VOL 309 SCIENCE www.sciencecareers.org POSITIONS OPEN FACULTY POSITION, IMMUNOLOGY Department of Microbiology and Immunology University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma The Department of Microbiology and Immunology at the University of Oklahoma Health Sciences Center invites applications for a 12-month, tenuretrack position at the ASSISTANT or ASSOCIATE PROFESSOR level with emphasis in immunology. Outstanding scientists in all areas of immunology are encouraged to apply. Applicants at the Assistant Professor level must have a Ph.D. or equivalent degree with at least two years of postdoctoral training. At the Associate Professor level, the candidate is expected to have an independent, extramurally funded research program. In addition to developing their own research program, the successful candidate will have the opportunity to interact with strong existing programs in basic immunology, cancer, and microbial pathogenesis. Close ties exist with immunologists at the adjacent Oklahoma Medical Research Foundation. Teaching responsibilities will involve participation in the immunology portions of the team-taught graduate, medical, and/or dental curricula within the Department. The Department currently has 14 full-time, tenured, or tenure-track faculty, more than 40 extramural grants and contracts, and ranks in the top 10 medical school microbiology departments in NIH funding. For an overview of the Department, visit our website: http://w3.ouhsc.edu/mi. Submit curriculum vitae, description of research interests and teaching experience, and the names and contact information, including e-mail addresses, of three references to e-mail: immuno-search@ouhsc.edu or mail to: Dr. Frank Waxman, Chair of the Search Committee, Department of Microbiology and Immunology, BMSB-1053, 940 S. L. Young Boulevard, Oklahoma City, OK 73104. Applications will be reviewed as they are received and the position will remain open until filled. The University of Oklahoma is an Equal Opportunity/Affirmative Action Employer. Applications from women and ethnic minorities are strongly encouraged. The Department of Chemistry at Lehman College of The City University of New York (CUNY) invites applications for the position of DEPARTMENT CHAIR beginning September 1, 2006; compensation commensurate with the applicant_s qualifications. The successful candidate will have a distinguished record of research and scholarly activity that is sufficient to merit appointment in the rank of FULL PROFESSOR with tenure, and have a significant record of extramural funding. The applicant should have expertise in either environmental chemistry or structural biochemistry. Applicants should hold a Doctorate in chemistry or biochemistry and should have excellent oral and administrative skills and a commitment to teaching at the undergraduate and graduate levels. The Chair is expected to provide leadership in expanding and further developing the Department, and to participate fully in the life of the College, including teaching, research, and faculty leadership groups. The position will be part of the University_s Flagship Initiative in either the Urban Environment or Structural Biology, and the successful applicant will be expected to participate in collaborative CUNYwide efforts in one of these areas. Applications containing a cover letter; curriculum vitae; statements of research experience, vision for undergraduate and graduate education, and departmental leadership philosophy; and the names of three references should be submitted before December 31, 2005, to: Search Committee for the Chair of the Department of Chemistry, Office of the Dean of Natural and Social Sciences, Lehman College, The City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468-1589. Please check the Lehman College website: http://www.lehman.cuny.edu for upcoming faculty announcements. Lehman College/CUNY is an Equal Employment Opportunity/Affirmative Action/ ADA/IRCA Employer.
Page 2 and 3:
2 September 2005 Vol. 309 No. 5740
Page 4 and 5:
$ """# % ## "$%$ ## !%$$$& " #$'"
Page 6 and 7:
SPECIAL ISSUE MAPPING RNA FORM AND
Page 10 and 11:
PERSPECTIVES 1498 NATURAL HISTORY B
Page 12 and 13:
REPORTS CONTINUED 1548 ATMOSPHERIC
Page 14 and 15:
sciencenow www.sciencenow.org DAILY
Page 16:
THIS WEEK IN edited by Stella Hurtl
Page 19 and 20:
What if moving from one particular
Page 22 and 23:
H IGHLIGHTS OF THE R ECENT L ITERAT
Page 24 and 25:
CREDITS: NELSON ET AL., PROC. NATL.
Page 26 and 27:
DISEASE: A 20-YEAR RIDDLE Well that
Page 29 and 30:
Finish your research projects in re
Page 31 and 32:
NEWS This Week PAGE 1471 1473 Good
Page 33 and 34:
New England Biolabs - an uncommon p
Page 35 and 36:
N EWS OF THE W EEK SPACE-BASED ASTR
Page 38 and 39:
CREDIT: BIO-GERM PROTECTION 2005 BI
Page 40 and 41:
CVS and amniocentesis are 99% accur
Page 42:
CREDIT: U.S. DEPARTMENT OF ENERGY N
Page 45 and 46:
Cosmology The Quest for Dark Energy
Page 47 and 48:
The power of small. It’s a small
Page 49 and 50:
Career advice, insight and tools. T
Page 51:
RANDOM SAMPLES PEOPLE Edited by Yud
Page 55 and 56:
L ETTERS São Paulo, Brazil Atlanti
Page 57 and 58:
Q Who’s delivering science to eve
Page 59 and 60:
B OOKS ET AL. of the relationship b
Page 61 and 62:
G LOBAL V OICES OF S CIENCE as an i
Page 63 and 64:
PERSPECTIVES NATURAL HISTORY Beyond
Page 65 and 66:
P ERSPECTIVES Selection Chimpanzee
Page 67 and 68:
P ERSPECTIVES observed by STM for s
Page 69 and 70:
The W. M. Keck Foundation is proud
Page 71 and 72:
Now it’s your turn to rock the wo
Page 73 and 74:
RNA S PECIAL S ECTION REVIEW RNA St
Page 75 and 76:
S PECIAL S ECTION RNA cleotides eac
Page 77 and 78:
RNA S PECIAL S ECTION impression th
Page 79 and 80:
RNA S PECIAL S ECTION 17. A. R. Fer
Page 81 and 82:
RNA S PECIAL S ECTION EJC is a set
Page 89 and 90:
RNA S PECIAL S ECTION translation l
Page 91 and 92:
RNA S PECIAL S ECTION rapidly, with
Page 93 and 94:
S PECIAL S ECTION RNA Fig. 2. A day
Page 95 and 96:
RNA S PECIAL S ECTION silencing mac
Page 97 and 98:
RNA S PECIAL S ECTION expressed seq
Page 99 and 100:
RNA S PECIAL S ECTION Ascribing fun
Page 101 and 102:
RNA S PECIAL S ECTION in EST databa
Page 103 and 104:
.:+2-21 /786463:21 0/ 8 320/6/2-/
Page 105 and 106:
RESEARCH ARTICLE Inositol Hexakisph
Page 107 and 108:
R ESEARCH A RTICLE IP 6 is required
Page 109 and 110:
R ESEARCH A RTICLE Fig. 6. (A) Edit
Page 111 and 112:
R EPORTS SWNT allows for an easily
Page 113 and 114:
R EPORTS Controlling the Kondo Effe
Page 115 and 116: R EPORTS system. Moreover, the crys
Page 117 and 118: R EPORTS cylindrical shells centere
Page 119 and 120: R EPORTS downhill currents is quite
Page 121 and 122: R EPORTS The long-term behavior of
Page 123 and 124: R EPORTS Our second method for esti
Page 125 and 126: R EPORTS Fig. 3. Atmospheric profil
Page 127 and 128: R EPORTS realizations reduces noise
Page 129 and 130: R EPORTS should be small due to nea
Page 131 and 132: R EPORTS large majority of transcri
Page 133 and 134: R EPORTS Fig. 3. Noncoding RNA prom
Page 135 and 136: R EPORTS Antisense Transcription in
Page 137 and 138: R EPORTS transcripts are processed
Page 139 and 140: R EPORTS Fig. 1. Small RNAs map to
Page 141 and 142: R EPORTS A Strategy for Probing the
Page 143 and 144: R EPORTS increase in NFAT activity
Page 145 and 146: R EPORTS ER-HA-RL expression was si
Page 147 and 148: R EPORTS Fig. 3. Localization of tr
Page 149 and 150: R EPORTS cells or even in human liv
Page 151 and 152: R EPORTS Fig. 4. Effects of mutatio
Page 153 and 154: R EPORTS Fig. 1. Bidirectional E-pr
Page 155 and 156: R EPORTS model is supported by evid
Page 157 and 158: R EPORTS spliceosomal introns (1)^.
Page 159 and 160: R EPORTS Fig. 1. The group I intron
Page 161 and 162: R EPORTS ner. The simultaneous coor
Page 163 and 164: Q: Where can I present my research
Page 165: special advertising section >> adva
Page 169 and 170: National Human Genome Research Inst
Page 171 and 172: United States National Institute of
Page 173: Director of Research with Endowed C
Page 177 and 178: Breast Cancer Basic Science Researc
Page 179 and 180: Research Faculty Positions in Thora
Page 181 and 182: Vice Chief of Cardiovascular Resear
Page 183 and 184: DUQUESNE UNIVERSITY CHAIR OF BIOLOG
Page 185 and 186: POSITIONS OPEN FACULTY POSITION, AN
Page 187 and 188: POSITIONS OPEN FACULTY POSITION Cel
Page 189 and 190: POSITIONS OPEN FACULTY POSITION: TH
Page 191 and 192: POSITIONS OPEN BIOMATERIALS/BIOTECH
Page 193 and 194: POSITIONS OPEN TENURE-TRACK FACULTY
Page 195 and 196: POSITIONS OPEN FACULTY POSITION, VI
Page 197 and 198: POSITIONS OPEN ANIMAL ECOLOGY Unive
Page 199 and 200: POSITIONS OPEN ECOLOGY AND ECONOMIC
Page 201 and 202: MARKETPLACE MARKETPLACE q: How can
show all

THIS WEEK IN

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?