C:\Eco-SSLs\Contaminant Specific Documents\Lead\November ...

Dose (mg Pb/kg bw/day)
10000.000
1000.000
100.000
74 75
74
71
73
76 78 72
68 78
66
70
66
66
80
6671
71
6670
71
8076
7174 73 75
74
71
70
10.000
1.000
0.100
78
78
78
78
66 78
66 78
68
72
72
77
72
69 77
72
69667267
727277
66 72
69 6972
72
7272
73
69
68
74
68 80
67 7179
70
70 66 7373
71
67
70
67
75
797373
80
69
72
74
666
72
7568
66
74
7267 67
68
6769
69 75
68
68
72
67
69
78
678372
67
75
71
69
8378
79
72
Figure 6.1 Mammalian TRV Derivation for Lead
Wildlife TRV Derivation Process Data Evaluation Score
74
79
77
74
81 72
77 81
76
8181
66
75
8181
76
68
71
66
67
68
7580 8072
67
7570
68 727575
7275
80 68
75 7575
68
72
66
68 7673
78 7673
68
85
67
667169728784736967
72
76
77
79
74
Lowest-Observed Adverse Effect Dose
Paired values from same study when joined by line
No-Observed Adverse Effect Dose
1) There are at least three results available for two test species within the growth, reproduction, and mortality effect groups. There are enough data to derive a TRV.
2) There are three NOAEL results available for calculation of a geometric mean.
72 79
74
77
78
86
668666
7979
69
7471
74 8772686878
74
7979
71
67
78
73
85
7374
87
72
84
71
87
81 69
77 746767
4) The geometric mean is equal to 40.7 mg/kg bw/d but is higher than the lowest bounded LOAEL for results within the reproduction, growth, and survival effect groups.
5) The mammalian wildlife TRV for lead is equal to 4.70 mg lead/kg bw/day which is the highest bounded NOAEL below the lowest bounded LOAEL for results in the growth, reproduction, and survival effect groups.
86 7816869
66
6974 7278696971737073737378686968686969686869696870
6969697366 7368787874
69 69
Geometric Mean of
NOAELs for REP and
GRO = 40.7
74
73
75
70
787878 78
70
8068 7173
80 6778697867
7179747171 83727171
73
80
72
67
68
75 7266
72 73
7173
69
78
71 83 8285
6766 677279
76
71
71767274767969 707968776767678585706779776671
67
8285
74
69 77
8585
77
77 71
77
76
72
70666706967
79
84 8476
73 79
72 79676779796771
TRV = Highest bounded NOAEL
lower than lowest bounded
LOAEL for REP, GRO or MOR =
4.70
Biochemical (BIO) Behavior (BEH)
Pathology (PTH) Reproduction (REP)
Growth (GRO)
Mortality (MOR)
BIO-NOAEL BIO-LOAEL BEH-NOAEL BEH-LOAEL PHY-NOAEL PHY-LOAEL PTH-NOAEL PTH-LOAEL REP-NOAEL REP-LOAEL GRO-NOAEL GRO-LOAEL MOR-NOAEL MOR-LOAEL
Eco-SSL for Lead 18 March 2005
83
6979 77
67 73
72
7279
79
8481
82 85
68 82
84 8188
68 7268
88
7366 80
83
68 85
8377
7373
6868
8686
72
6886868
80
86
86
7267 73
67
77
72
80 8480
727472