C:\Eco-SSLs\Contaminant Specific Documents\Lead\November ...

Result #
Ref N.
Chemical Form
MW%
Appendix 6.1 Mammalian Toxicity Data Extracted for Wildlife Toxicity Reference Value (TRV)
Lead
Page 10 of 12
Ref Exposure Effects Conversion to mg/kg bw/day
Test Species
# of Conc/ Doses
Conc/ Doses
Conc/Dose Units
Wet Weight Reported?
Percent Moisture
Application Frequency
Method of Analyses
Route of Exposure
Exposure Duration
Duration Units
Age
Age Units
Lifestage
Sex
Control Type
Effect Type
Effect Measure
Response Site
Study NOAEL
Study LOAEL
Body Weight Reported?
Body Weight in kg
Ingestion Rate Reported?
Ingestion Rate in kg or L/day
NOAEL Dose (mg/kg/day)
Result Data Evaluation Score
470 14752 Piasek and Kostial, 1990 Lead acetate 100 Rat (Rattus norvegicus ) 4 0/1500/3500/5500 mg/L N ADL U DR 6 w 15 w LC B C PHY BLPR BL 5500 Y 0.185 N 0.02168 645 10 5 5 5 6 4 4 10 10 4 63
471 2505 Lamb et al., 1997 Lead acetate trihydrate 100 Mouse (Mus musculus ) 2 0/0.67 g/kg bw/d N ADL U DR 105 d 6 w JV B C GRO BDWT WO 0.670 Y 0.0376 N 0.00517 670 10 5 5 5 10 8 4 1 10 4 62
472 2505 Lamb et al., 1997 Lead acetate trihydrate 100 Mouse (Mus musculus ) 2 0/0.67 g/kg bw/d N ADL U DR 105 d 6 w JV B C ORW ORWT LI 0.670 Y 0.0376 N 0.00517 670 10 5 5 5 10 4 4 1 10 4 58
473 2818 Piasek and Kostial 1991 Lead acetate 100 Rat (Rattus norvegicus ) 2 0/750 mg/kg bw/d N NR U DR 20 w 10 w GE F C MOR MORT WO 750 Y 0.2681 N 0.03028 750 10 5 5 5 10 9 4 1 10 4 63
474 3749 Ogilvie, 1977 Lead acetate 54.61 Mouse (Mus musculus ) 2 0/10 mg/ml N NR U DR 2 w NR NR AD M C MOR MORT WO 10.0 Y 0.0328 N 0.00457 761 10 5 5 5 6 9 4 1 3 4 52
475 2523 Barlow et al., 1977 Lead acetate 54.61 Rat (Rattus norvegicus ) 2 0/2 % in diet N ADL U FD 21 d NR NR LC F C ORW ORWT BR 2.00 N 0.21 N 0.01905 991 10 10 5 5 5 4 4 1 10 4 58
476 2505 Lamb et al., 1997 Lead acetate trihydrate 100 Mouse (Mus musculus ) 4 0/0.67/1.00/1.50 g/kg bw/d N ADL U DR 105 d 6 w JV B C FDB WCON WO 1.50 Y 0.0376 N 0.00517 1500 10 5 5 5 10 4 4 1 10 4 58
477 2698 Holtzman et al., 1981 Lead carbonate 77.55 Rat (Rattus norvegicus ) 2 0/4 % in diet N ADL U FD 8 w 60-80 d JV M C ITX PARL LG 4.00 N 0.523 N 0.04032 2390 10 10 5 10 5 4 4 1 10 4 63
478 2781 Murthyet al., 1991 Lead acetate 100 Rat (Rattus norvegicus ) 2 0/4.78 mg/org/d N ADL U DR 70 d NR NR JV M C FDB FCNS WO 250 Y 0.045 N 0.00607 5560 10 5 5 5 6 4 4 1 10 4 54
479 2781 Murthy et al., 1991 Lead acetate 100 Rat (Rattus norvegicus ) 2 0/4.78 mg/org/d N ADL U DR 70 d NR NR JV M C GRO BDWT WO 250 Y 0.045 Y 0.0061 5560 10 5 5 5 7 8 4 1 10 4 59
480 2781 Murthyet al., 1991 Lead acetate 100 Rat (Rattus norvegicus ) 2 0/4.78 mg/org/d N ADL U DR 70 d NR NR JV M C REP TEDG TE 250 Y 0.045 N 0.00607 5560 10 5 5 5 6 10 4 1 10 4 60
481 2694 Hilderbrand et al., 1973 Lead acetate 54.61 Rat (Rattus norvegicus ) 3 0/5/100 ug/org/d N DLY U OR 30 d NR NR SM M C BEH INST WO 5.00 Y 0.245 N 0.02162 0.0111 10 8 5 5 6 4 4 10 3 4 59
482 2694 Hilderbrand et al., 1973 Lead acetate 54.61 Rat (Rattus norvegicus ) 3 0/5/100 ug/org/d N DLY U OR 30 d NR NR LC M C CHM ASCA UR 5.00 Y 0.245 N 0.02162 0.0111 10 8 5 5 6 1 4 10 3 4 56
483 2694 Hilderbrand et al., 1973 Lead acetate 54.61 Rat (Rattus norvegicus ) 3 0/5/100 ug/org/d N DLY U OR 30 d 24 d JV M C REP TEWT PG 5.00 Y 0.245 N 0.02162 0.0111 10 8 5 5 6 10 4 10 3 4 65
484 14697 USEPA, 1980 Lead 100 Rat (Rattus norvegicus ) 3 0/5/50 mg/l N NR U DR 40 d 40 d JV M C BEH ACTV WO 5.00 N 0.217 N 0.02503 0.577 10 5 5 4 5 4 4 10 10 4 61
485 14697 USEPA, 1980 Lead 100 Rat (Rattus norvegicus ) 3 0/5/50 mg/L N NR U DR 40 d NR NR AD M C CHM 5HAA BR 5.00 N 0.217 N 0.02503 0.577 10 5 5 4 5 1 4 10 10 4 58
486 2654 Gonzalez-Riola et al., 1997 Lead acetate 54.61 Rat (Rattus norvegicus ) 2 0/17 mg/kg diet N ADL U FD 50 d 21 d GE F C GRO BDWT WO 17.0 Y 0.2756 N 0.02382 0.802 10 10 5 5 6 8 4 10 3 4 65
487 2616 Escribano et al., 1997 Lead acetate 54.61 Rat (Rattus norvegicus ) 2 0/17 mg/kg diet N NR U FD 50 d 50 d AD F C MPH GMPH WO 17.0 Y 0.2756 N 0.02382 0.802 10 10 5 5 6 8 4 10 3 4 65
488 2905 Tafelski and Lamperti, 1975 Lead acetate 54.61 Rat (Rattus norvegicus ) 4 0/1/5/10 mg/org N DLY U GV 29 d NR NR SM F C ENZ ALAD BL 1.00 Y 0.283 N 0.02434 1.93 10 8 10 5 6 1 4 10 6 4 64
489 2930 Wiebe and Barr, 1988 Lead chloride 100 Rat (Rattus norvegicus ) 3 0/20/200 mg/L N NR U DR 14 d 21 d JV F C HRM ESDL UT 20.0 Y 0.1228 N 0.0150 2.44 10 5 5 10 6 1 4 10 10 4 65
490 2763 Maxfield et al., 1975 Lead acetate 100 Dog (Canis familiaris ) 2 0/2.5 mg/kg bw/d N NR U FD 76 w