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Decision-making<br />

Delivering evidence <strong>to</strong> inform<br />

<strong>health</strong> system streng<strong>the</strong>ning:<br />

<strong>the</strong> role of systematic reviews<br />

Article by Sara Bennett<br />

Increasingly <strong>health</strong> system bottlenecks are perceived as <strong>the</strong><br />

principle barriers <strong>to</strong> scaling up <strong>the</strong> use of critical <strong>health</strong><br />

services <strong>and</strong> achieving public <strong>health</strong> goals 1 . While this<br />

perception perhaps started with a concern about lack of<br />

human resources, <strong>the</strong>re is now broader recognition of <strong>the</strong><br />

problems that multiple <strong>health</strong> system constraints, such as<br />

inequitable systems of <strong>health</strong> financing, poor quality services,<br />

fragmented information systems, <strong>and</strong> weak accountability<br />

structures present. At <strong>the</strong> time of writing, several new major<br />

initiatives at <strong>the</strong> global level, including <strong>the</strong> UK government<br />

International Health Access Initiative, <strong>the</strong> Norwegian<br />

government Millennium Development Goals 4 <strong>and</strong> 5<br />

Initiative, <strong>the</strong> Canadian government African Health Systems<br />

Initiative, as well as initiatives from <strong>the</strong> GAVI Alliance <strong>and</strong><br />

potentially <strong>the</strong> Global Fund <strong>to</strong> Fight AIDS, TB <strong>and</strong> Malaria,<br />

indicate that <strong>the</strong>re will be substantially increased investments<br />

in <strong>health</strong> systems in <strong>the</strong> near future. But how best <strong>to</strong> invest<br />

<strong>the</strong>se new resources in order <strong>to</strong> achieve <strong>health</strong> goals?<br />

While <strong>the</strong>re are certain similarities across low- <strong>and</strong> middleincome<br />

country contexts in terms of <strong>the</strong> nature of <strong>health</strong><br />

system barriers, <strong>the</strong>re is also wide variation in <strong>health</strong> system<br />

structures <strong>and</strong> <strong>social</strong> values that mean it is not possible <strong>to</strong><br />

craft a “one-size-fits-all” solution. Health systems<br />

interventions will never be able <strong>to</strong> be reduced <strong>to</strong> easy <strong>to</strong><br />

prescribe formulae such as DOTS. National-level policymakers<br />

must craft <strong>health</strong> policies, plans <strong>and</strong> system<br />

streng<strong>the</strong>ning interventions that match <strong>the</strong>ir country’s specific<br />

needs. What role can evidence <strong>and</strong> particularly evidence<br />

drawn from systematic reviews play in ensuring that <strong>the</strong><br />

national policies <strong>and</strong> strategies chosen are effective?<br />

During <strong>the</strong> past ten years Evidence Based Medicine has<br />

had a major impact on how clinicians, managers <strong>and</strong> policymakers<br />

think about clinical practices 2 . Systematic reviews<br />

Systematic reviews have <strong>the</strong> advantage of providing<br />

findings based upon <strong>the</strong> best available evidence, <strong>and</strong><br />

in being transparent about <strong>the</strong> source of evidence <strong>and</strong><br />

how <strong>the</strong> evidence has been interpreted<br />

have <strong>the</strong> advantage of providing findings based upon <strong>the</strong> best<br />

available evidence, <strong>and</strong> in being transparent about <strong>the</strong> source<br />

of evidence <strong>and</strong> how <strong>the</strong> evidence has been interpreted.<br />

However in <strong>the</strong> context of <strong>health</strong> policy <strong>and</strong> systems research<br />

in low- <strong>and</strong> middle-income countries, systematic reviews<br />

have only been undertaken <strong>to</strong> a very limited degree, <strong>and</strong><br />

although <strong>the</strong>re is no data on <strong>the</strong> <strong>to</strong>pic, it appears that <strong>to</strong>-date<br />

<strong>the</strong>y have played virtually no role in influencing policy.<br />

This paper focuses on <strong>the</strong> potential contribution that<br />

systematic reviews could make <strong>to</strong> policy decisions regarding<br />

<strong>health</strong> systems in low- <strong>and</strong> middle-income countries, <strong>and</strong> <strong>the</strong><br />

challenges <strong>to</strong> actually using systematic reviews for this<br />

purpose. The paper does not address <strong>the</strong> nature of dem<strong>and</strong><br />

for systematic reviews by policy-makers nor <strong>the</strong>ir capacity <strong>to</strong><br />

use <strong>and</strong> apply systematic review evidence, although both of<br />

<strong>the</strong>se questions raise complex issues in <strong>the</strong>ir own right.<br />

The potential for systematic reviews <strong>to</strong><br />

contribute <strong>to</strong> policy<br />

For many questions that <strong>health</strong> policy <strong>and</strong> decision-makers<br />

might ask (What is <strong>the</strong> best way <strong>to</strong> extend financial <strong>protection</strong><br />

<strong>to</strong> those seeking <strong>health</strong> care? How have <strong>health</strong> workers<br />

responded <strong>to</strong> alternative incentive mechanisms? Which<br />

strategies are most effective in terms of improving quality of<br />

care?) a substantial body of evidence exists, but this evidence<br />

is often scattered <strong>and</strong> not available in a form that decisionmakers<br />

find easy <strong>to</strong> appraise or use. Systematic reviews of<br />

<strong>health</strong> policy <strong>and</strong> systems research have <strong>the</strong> potential <strong>to</strong><br />

reduce bias in <strong>the</strong> estimation of <strong>the</strong> effectiveness of a policy<br />

option by identifying all relevant studies, selecting those that<br />

meet explicit criteria, appraising <strong>the</strong>ir quality, <strong>and</strong><br />

syn<strong>the</strong>sizing <strong>the</strong> results using a transparent process.<br />

Systematic reviews reduce <strong>the</strong> role that chance has <strong>to</strong> play in<br />

estimating effectiveness or cost-effectiveness, <strong>and</strong> allow more<br />

precise estimation of <strong>the</strong> impact of a policy option.<br />

Systematic reviews offer considerable advantages <strong>to</strong> <strong>the</strong><br />

decision-maker. First, drawing on an existing systematic<br />

review constitutes a more efficient use of time for research<br />

users, enabling <strong>the</strong>m <strong>to</strong> draw upon <strong>the</strong> research literature<br />

without having <strong>to</strong> comb through it <strong>the</strong>mselves. Second,<br />

research users are less likely <strong>to</strong> be misled by results of a<br />

systematic review than a single investigation <strong>and</strong> <strong>the</strong>refore<br />

can be more confident about what can be expected.<br />

148 ✜ Global Forum Update on Research for Health Volume 4

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