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Innovation<br />

Health system<br />

streng<strong>the</strong>ning<br />

US$ 92 million<br />

GAVI country-specific<br />

programmes*<br />

US$ 210 million<br />

Yellow Fever<br />

US$ 38 million<br />

Maternal <strong>and</strong><br />

neonatal tetanus<br />

US$ 49 million<br />

Polio<br />

US$ 191 million<br />

Pentavalent<br />

US$ 181 million<br />

Measles<br />

US$ 139 million<br />

Source: The GAVI Fund, Washing<strong>to</strong>n DC, United States, 2007<br />

* including vaccines <strong>and</strong> safety equipment<br />

Figure 1: Expected IFFIm disbursements, 2006–2007<br />

Ethiopia will receive a <strong>to</strong>tal of US$ 76.5 million for <strong>health</strong><br />

system streng<strong>the</strong>ning for 2007–2009, with <strong>the</strong> majority –<br />

US$ 56 million – arriving in 2007.<br />

The predictability of this funding is an essential part of its<br />

value. Fragile economies cannot give firm assurances of<br />

consistent financial support <strong>to</strong> long-term plans. But plans<br />

involving human resources training have <strong>to</strong> be sustained.<br />

Breakthrough funding like this from IFFIm makes all <strong>the</strong><br />

difference: it assures <strong>the</strong> whole period.<br />

Equally essential in this mix is a solid national plan that can<br />

bear <strong>the</strong> strain of such dramatic acceleration. And <strong>the</strong> end<br />

result has <strong>to</strong> bring <strong>the</strong> widest possible range of benefits.<br />

Tedros Ghebreyesus, Ethiopian Minister of Health <strong>and</strong> GAVI<br />

Alliance board member, described <strong>the</strong> critical significance of<br />

<strong>the</strong> new programme <strong>to</strong> improving his country’s <strong>health</strong><br />

services. He said, “Our vehicle has not been strong enough<br />

<strong>to</strong> carry all <strong>the</strong> programmes we have loaded on it. Now we<br />

are working <strong>to</strong> streng<strong>the</strong>n <strong>the</strong> vehicle so that it can carry all<br />

our programmes, <strong>the</strong> vaccines <strong>and</strong> <strong>the</strong> o<strong>the</strong>r <strong>health</strong> care<br />

interventions, <strong>to</strong> every corner of this vast country.”<br />

The benefits of this type of funding go beyond providing<br />

stability <strong>to</strong> developing country plans. It also has marketshaping<br />

potential – a vital component in <strong>the</strong> endeavour <strong>to</strong><br />

increase access <strong>to</strong> new <strong>and</strong> better vaccines through using<br />

market forces <strong>and</strong> economies of scale <strong>to</strong> stimulate dem<strong>and</strong><br />

<strong>and</strong> reduce product prices.<br />

By signaling financial stability <strong>and</strong> long-term committed<br />

financing, it is also possible <strong>to</strong> spur larger markets, accelerate<br />

vaccine development, <strong>and</strong> promote increased production,<br />

availability <strong>and</strong> lower prices.<br />

For example, IFFIm funds are being used <strong>to</strong> stimulate<br />

increased dem<strong>and</strong> for combination vaccines not currently<br />

produced in sufficient quantities. US$ 181 million of IFFIm<br />

funding has allowed <strong>the</strong> GAVI Alliance <strong>to</strong> make a binding<br />

commitment <strong>to</strong> purchase “5-in-1” pentavalent vaccine at a<br />

reduced price by making a longer-term commitment. This<br />

product provides, in a single shot, <strong>protection</strong> against five<br />

diseases: diph<strong>the</strong>ria, tetanus, pertussis, hepatitis B <strong>and</strong> Hib.<br />

The availability of IFFIm funds over <strong>the</strong> next decade supports<br />

security of supply: it also provides an incentive <strong>to</strong> new<br />

manufacturers <strong>to</strong> enter <strong>the</strong> market, a dynamic which can<br />

fur<strong>the</strong>r reduce vaccine price.<br />

This dynamic – <strong>the</strong> “pull fac<strong>to</strong>r” of having long-term,<br />

substantial funding ready – has already worked very well in<br />

support of <strong>the</strong> global polio eradication campaign. In a WHOled<br />

initiative, a s<strong>to</strong>ckpile of completely new monovalent<br />

vaccines <strong>to</strong> secure <strong>the</strong> post-eradication phase is being<br />

generated. The IFFIm funding was essential <strong>to</strong> spur<br />

manufacturers rapidly <strong>to</strong> manufacture <strong>and</strong> evaluate <strong>the</strong> new<br />

vaccines that are critical <strong>to</strong> this process. Demonstrating <strong>the</strong><br />

asset of flexibility, when <strong>the</strong> eradication campaign alerted <strong>the</strong><br />

Boards of <strong>the</strong> GAVI Alliance <strong>to</strong> a critically damaging funding<br />

gap, reprogramming of IFFIm funds allowed (exceptionally)<br />

this crisis <strong>to</strong> be averted <strong>and</strong> <strong>the</strong> campaign <strong>to</strong> continue<br />

unimpeded.<br />

Through <strong>the</strong> GAVI Alliance, <strong>the</strong> catalytic funding IFFIm<br />

offers is quickly channelled <strong>to</strong> where it will have most impact.<br />

In line with <strong>the</strong> concept that early intervention with<br />

vaccination incrementally saves lives in infectious disease<br />

epidemics, an early investment was in a s<strong>to</strong>ckpile of yellow<br />

fever vaccine, working through <strong>the</strong> Yellow Fever Initiative.<br />

This was rapidly useful when, three months after IFFIm<br />

was launched, Togo reported an outbreak of this highly<br />

infectious <strong>and</strong> lethal viral disease. In <strong>the</strong> first two weeks of<br />

February 2007, a broad range of partners, led by <strong>the</strong> Ministry<br />

of Health in close collaboration with WHO, worked <strong>to</strong>ge<strong>the</strong>r <strong>to</strong><br />

bring yellow fever vaccine <strong>to</strong> 1.33 million Togolese in 11<br />

districts of <strong>the</strong> Savanes <strong>and</strong> Kara regions.<br />

In a fur<strong>the</strong>r benefit, <strong>the</strong> risk assessment activities<br />

undertaken as part of <strong>the</strong> Initiative in 12 countries in Africa,<br />

Global Forum Update on Research for Health Volume 4 ✜ 097

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