Vol 44 # 2 June 2012 - Kma.org.kw

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Evaluating the Association between Premenstrual Syndrome and Hematologic Parameters ...
June 2012
close to the normal values. Estrogen has an influence
over plasma fasting blood glucose levels and this may
lead to different responses against hypoglycemia.
Glucose levels have been shown to be lower during
the luteal phase compared with the follicular phase [33] .
Decreased glucose levels and an increased appetite
for sweets during the luteal phase may indicate the
metabolic need for sugar. This may be the reason why
people with elevated sugar levels are affected less by
fatigue.
The women with low iron levels were found to
have higher scores for changes in sleeping habits
compared with the ones with high iron levels. Pittori
et al found that having low values for anemia-related
parameters (serum ferritin, complete blood count)
caused excessive weakness, fatigue, sleep disorders,
headache, anxiety, hair loss, and nail breakage [34] .
As a result of impaired monoamine oxidase activity,
iron deficiency is associated with apathy, drowsiness,
irritability, reduced attention and concentration, and
memory loss [35] . The individuals with a normal or
low MCHC levels were found to have higher anxiety
levels compared with those with high MCHC values.
Maes et al found that examination stress significantly
reduced hemoglobin, hematocrit, MCV, MCH, and
MCHC levels [36] . In this study, the individuals with
higher neutrophil levels were observed to experience
anxiety, fatigue, and PMS more frequently compared
with the ones with normal and high neutrophil values.
Stress, anxiety or negative emotions were thought to
affect hematologic parameters in a negative way. The
stress-related changes in hematologic parameters
were observed to be more frequent among people
experiencing stress-related anxiety. This suggests that
personality traits may be influential in stress-related
hematologic responses.
CONCLUSION
Our study shows that women with low serum iron
levels, low and normal MCHC, and normal fasting
blood glucose, as well as those with elevated BMI
experience the symptoms of PMS more frequently.
Women with a high neutrophil count during the LL
phase suffer PMS more frequently, as well. The raised
values of leukocyte count prior to the menstruation
suggest that menstrual cycle is associated with
inflammation. Moreover, menstrual cycle is thought
to be a serious source of stress for young women.
Our study reveals the importance of controlling BMI,
anemia, and blood sugar with regard to alleviation of
PMS symptoms.
ACKNOWLEDGEMENTS
This study was not supported by any financial
grant. We thank our subjects for participating in the
study.
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