Vol 43 # 2 June 2011 - Kma.org.kw

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Selected Abstracts of Articles Published Elsewhere by Authors in Kuwait June 2011
Prevalence of Human Papillomavirus among Women
with Normal Cervical Cytology in Kuwait
Al-Awadhi R, Chehadeh W, Kapila K
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait. E-mil:
r.al-awadhi@hsc.edu.kw
J Med Virol 2011; 83:453-460.doi: 10.1002/jmv.21981
This study was undertaken to determine the prevalence and type specific distribution of human
papillomavirus (HPV) in women with normal cervical cytology in Kuwait. The study is the first of
its type in Kuwait and one of few in the Middle East. The age specific distribution of HPV types was
determined in 3,011 ThinPrep samples taken from women seeking routine gynaecological care. ThinPrep
samples were screened for HPV DNA by real-time PCR. The type specific distribution of the viruses was
determined by PCR-based sequencing. The results showed that HPV DNA was detected in 71 women
(2.4%), and 21 different HPV genotypes were detected, comprising eight high-risk (HR) (16, 31, 33, 53,
56, 58, 66, and 73), seven low-risk (LR) (6, 11, 54, 61, 70, 81, and 90), four intermediate-risk (IR) (67, 82, 83,
and 84) and HPV 102 and HPV 106. LR HPV types were found in 71.8% of infected samples, HR types
in 32.3%, and IR types in 7%. With regard to age, 40.8% of all HPVs were found in women 30 - 39 years
of age, 29.6% in women 40 - 49 years of age, 19.7% in women over 50 years and 9.9% in women less than
34 years old. The study shows that the prevalence of HPV infection in Kuwait is among the lowest in the
world and suggests that HPV vaccine could prevent the development of HPV associated cervical cancer
in 1.39% of young females living in Kuwait. However, more extensive population-based studies should
be undertaken before implementing HPV vaccination.
Cerebral venous Thrombosis in Kuwait. Clinical
Presentation, Risk Factors, and Management
Vembu P, John JK, Mohammed MI, Al-Shubaili AF
Department of Neurology, Ibn Sina Hospital, PO Box 25427, Safat 13115, Kuwait
Tel. +965 24840837; Fax: +965 24849226; E-mail: drvperiasamy@yahoo.com
Neurosciences (Riyadh) 2011; 16:129-316
Objective: To explore the pattern of clinical presentations, risk factors, and the sinuses involved in cases
of cerebral venous thrombosis (CVT) treated in a tertiary neurological center in Kuwait.
Methods: A retrospective analysis of cases of CVT treated at Ibn Sina Hospital, Kuwait, from January 2000
to October 2010. The records of 71 patients were retrieved and entered in a database. All patients were
evaluated with hypercoagulable work up and relevant neuro-imaging studies.
Results: Seventy-one patients were included in our study, with a male to female ratio of 1:1.5. The clinical
presentations were: headache (93%), seizures (31%), and focal neurological signs (37%). Over twothirds
(n = 30) of female patients had a history of oral contraceptive use. Papilledema with raised
intracranial pressure was recorded in 20 patients (28%), ovarian hyper-stimulation syndrome with
CVT in one patient, and possible Neuro-Behcet`s in 10% (n = 7). The venous sinuses involved were
superior sagittal sinus in 59% (n = 42), and transverse and straight sinuses in 54% (n = 38). Hemorrhagic
venous infarctions were seen in 18% (n = 13). Fifty percent of patients recovered within 2 - 4 weeks, 15
patients (21%) recovered within 4 -12 weeks, and 15 patients (21%) required intensive care unit care
with ventilator support for 1 - 2 weeks.
Conclusion: Oral contraceptive use was the primary risk factor in female patients. Early diagnosis and
immediate treatment with anticoagulants reduce the morbidity and mortality. Serum D-dimer level is
more helpful for early diagnosis with sensitivity of 58%.