Douglas J. Rhee, MD

46Side Effects:Drug Preparation Side Effectsacyclovir PO GI disturbances, rash, headache, elevated creatinine, confusionIV Reversible crystalline nephropathy (avoidable with adequate oral hydration), phlebitis,hallucinations, seizures, coma, encephalopathy, rashcidofovir Intravit Hypotony, iritis (causing posterior synechia and cataract), 1 – intravitreal administration nolonger recommendedIV Nephrotoxicity, iritis, hypotony, neutropenia, metabolic acidosis.famciclovir PO Headache, nausea, fatiguefoscarnet IV Renal impairment, Ca, K, Phos & Mg abnormalities, seizures, anemia, fever, nausea,diarrhea, headache, neutropenia.ganciclovir IV Myelosuppression, thrombocytopenia, liver function abnormalities, renal dysfunction,headaches, GI upset, psychiatric disturbances, seizure, anemia, inhibition ofspermatogenesis, teratogen; do not give in conjunction with AZT (worsens neutropenia)valacyclovir PO Possible association with thrombotic thrombocytopenic purpura/hemolytic uremiasyndrome in immunocompromised host with high doses, otherwise similar to acyclovir.1 From Ophthalmology 1997;104:1827–1837.