Douglas J. Rhee, MD

Drug Trade Dose Notesceftriaxone Rocephin 100 mg/kg/day IV in 2 divided dosesANDvancomycin Vancocin 40 mg/kg/day IV in 3–4 divided doses Pediatric dose 215 mg/kg load, maintenance dose 10 mg/kg Neonatal dose 2BID-TID(b) AdultsGive either ampicillin/sulbactam alone or ceftriaxone plus vancomycin.Drug Trade Dose Notesampicillin /sulbactam Unasyn 1.5 gm–3.0 gm IV Q6 hr × 7 daysceftriaxone Rocephin 1–2 gm IV Q12 hr × 7 days Continue oral antibiotics on dischargevancomycin Vancocin 1 gm IV Q12 hr × 7 days 2 Continue oral antibiotics on dischargeNotes: 1. If highly suspect adults with anaerobic infections, consider adding metronidazole 15 mg/kg IV load, then 7.5 mg/kg IV Q6 hr,or clindamycin 600mg IV Q8 hr. (Ampicillin /sulbactam alone has adequate anaerobic coverage.)2. If adult patient is allergic to penicillin/cephalosporin, may use vancomycin plus gentamicin 2.0 mg/kg IV loading dose, then1 mg/kg IV Q8 hr or clindamycin 600 mg IV Q8 hr plus gentamicin.3. Case reports have documented the appearance of methicillin-resistant Staphyloccus aureus as a causative agent innonhospitalized adults and children.Antibacterial Agents 23