Douglas J. Rhee, MD

126IntravenousCreatinine Clearanceinterval (mL/min/1.73 m 2 ) Percent of recommended dose Dosing interval>50 100% q8 hours25–50 100% q12 hours10–25 100% q24 hours0–10 50% q24 hoursCidofovir Dosing in Renal Failure 2Dose must be reduced from 5 mg/kg to 3 mg/kg for an increase in creatinine of 0.3–0.4 mg/dl above baselineDiscontinue for increase ≥0.5 mg/kg above baseline or development of ≥3 + proteinuriaFamciclovir Dosing in Renal Failure 2Creatinine clearance (mL/min) Adjusted dose>60 500mg every 8 hours40–59 500 mg every 12 hours20–39 500 mg every 24 hours