Douglas J. Rhee, MD

62F. PROSTAGLANDINS 1 (TEAL TOP)Mechanism of Action: Prostaglandin FP agonist which increases uveoscleral outflow by upregulating matrix metalloproteinases.Side Effects:Local: Increase in melanin pigmentation in iris, blurred vision, eyelid redness; cystoid macular edema and anterior uveitis have beenreported.Systemic: Systemic upper respiratory infection symptoms, backache, chest pain, myalgia.Contraindications: Pregnancy; use with caution in women of child bearing potential and inform the woman of the risks to potentialpregnancies; consider avoiding for uveitic glaucoma.Drug Trade Bottle Size Concentration Usual Dose Notesbimatoprost Lumigan 2.5, 5 ml Susp, 0.03% QHSlatanoprost Xalatan 2.5 ml Susp, 0.005% QHStravoprost Travatan, 2.5, 5 ml Susp, 0.004% QHS Does not require refrigerationTravatan ZNote: Must be refrigerated prior to opening; good for 6 weeks once opened.1 For listing of preservatives of antiglaucoma medications, refer to Appendix 5.