Douglas J. Rhee, MD

44Drug Trade Dose Notesfoscarnet Foscavir IV induction 90 mg/kg Q12 hr (infuse over For CMV retinitis in HIV+ patients; must adjust IV dose in1.5–2 hr) for 2–3 weeks or 60 mg/kg renal failure 1 ; hydration reduces risk of nephrotoxicity; do(infuse over 1 hr) Q8 hr for 2–3 weeks not administer by bolus IV infusion— must use infusionpump.IV maintenance 90–120 mg/kg (infuseover 2 hr)QD for 5–7 days/weekIntravitreal induction 1.2 mg in 0.05 ml2–3×/weekIntravitreal maintenance 1.2 mg in 0.05 mlQweek40 mg/kg IV Q8–12 hr (infuse over 1 hour) For HSV infection not responsive to scyclovirganciclovir Cytovene IV induction 5 mg/kg BID × 2–3 weeks For CMV retinitis in HIV+ patients, must adjust dose inIV maintenance 5 mg/kg QD × 7 days/ renal failure 1week or 6 mg/kg QD 5 days/week Caution when administeringIntravitreal (low dose) 200 µg in 0.1 ml Ganciclovir and AZT because both drugs cause anemia and(induction) 2–3×/wk for 2–3 weeks, neutropeniathen 200 µg in 0.1 ml Qwk. Do not administer if absolute neutrophil count(maintenance)