Douglas J. Rhee, MD

34A. AGENTSDrug Trade Concentration/ Route of Admin Usual Dose Notesamphotericin B 1 Fungizone Soln, 0.15% Q1–6 hr Varies depending on pathogenSubconj 0.8–1.0 mgIntravitreal 5 µg/0.1 mlIV 0.8–1.0 mg/kg/dayfluconazole 1,2 Diflucan PO/IV 400 mg on day 1, then Max daily dose 400 mg100–400 mg QDflucytosine 1 Ancobon Soln, 1% Q1–6 hr Varies depending on pathogenPO 50–150 mg/kg in 4 divided Used only as adjunctive treatment;doses serum levels must be followeditraconazole 2 Sporanox PO 200 mg QD-BIDketoconazole 1,2 Nizoral PO 200–400 mg QD Take with foodmiconazole Monistat Soln, 1, 2% Q1–6 hr Varies depending on pathogenSubconj 5–10 mgIntravitreal 10 µgnatamycin Natacyn Susp, 5% Q1–6 hr Varies depending on pathogenvoriconazole Vfend 200 mg PO BID Varies depending on pathogen1Toxic agent with protential severe side effects- refer to product information and warnings before use. Some side effects listed above.2Drug has potential to interact with some medications and may precipitate acute ventricular arrythmia (i.e., terfenadine, astemizole, cisapride, triazolam).Refer to package insert for full listing.