Douglas J. Rhee, MD

(2) Local Anesthetics 1 (to convert percent solutions to mg/ml, multiply by 10; e.g., 1% = 10 mg/ml)Drug Trade Preparation Maximum Adult Dose Duration of Action Pain on Injection 2 Linkage 3bupivacaine Marcaine, Soln, 0.25– 23 ml of 0.75% soln 3 to 12 hr 5 AmideSensorcaine 0.75%chloroprocaine Nesacaine Soln, 1–3% 40 ml of 2% soln 60 min N/A Esteretidocaine Duranest Soln 1% 40 ml of 1% soln 5–10 hr N/A Amidehexylcaine Soln, 1–2% 60 min N/A Esterlidocaine Xylocaine AmideWithout epinephrine Soln, 1–2% 15 ml of 2% soln 60 to 75 min. 1With epinephrine Soln, 1–2% 25 ml of 2% soln 2 hr. 2mepivacaine Carbocaine Soln, 1–2% 15 ml of 2% soln 2 to 3 hr 4 Amideprocaine Novocaine Soln, 1–4% 38 ml of 2% soln 30 to 45 min. 3 Ester(3) Adjuncts 1Drug Trade Preparation Usual Dose Noteshyaluronidase Vitrase 200 USP units/ml 50–300 units, typical dose Depolymerizes polysaccharides and150 USP units increases effective area of anesthesia,decreases duration of local anesthesiaLyophilized, 6200 USP Reconstitute to 1000 USP units/ Depolymerizes polysaccharides andunits vial by adding 6.2 ml of increases effective area of anesthesia,solution to the vial. decreases duration of local anesthesiaCommon dose is 150 USP unitssodium bicarbonate 1 mEq/ml 1 ml in 10 ml anesthetic Decreases pain on injectionMiscellaneous Conditions 99