Douglas J. Rhee, MD

50(5) Toxoplasmosis retinochoroiditis (Toxoplasma gondii )Drug Trade Dosing for Acute Infection Maintenancepyrimethamine Daraprim 200 mg PO load, then 50–75 mg PO QD 50–75 mg PO QD× 4–6 weeksPLUSsulfadiazine 4 1–1.5 gm PO or IV Q6 hr × 4–6 weeks 500 mg–1 gm PO Q6 hrPLUSfolinic acid 5 10 mg PO QD × 4–6 weeks 10 mg PO QDOther Alternativesclindamycin (may substitute if sulfa allergic) 300–600 mg PO QID or 900 mg IV QID 300 mg PO QID× 4–6 weeksNote: May consider concurrent treatment with oral prednisone (1 mg/kg/day) for inflammationTrimethoprim/sulfamethoxazole Bactrim 10/50 mg/kg/day PO divided BIDSingle drug therapy withTMP/SMX was as effective as combinationtherapy with pyrimethamine andsulfadiazine in a prospective,randomized trial 6PLUSclarithromycin 1 gm PO BID