Douglas J. Rhee, MD

(a) Early: Primary, Secondary, or Latent Infection Less Than 1 YearDrug Dosepenicillin G benzathine 2.4 million U IM once (may repeat 7 days later in patients with AIDS)ORone of the following for penicillin-allergic patients:doxycycline 100 mg PO BID × 14 daysazithromycin 2 gm PO × 1erythromycin 500 mg PO Q6 hr × 14 days(b) Late: Includes Isolated Anterior Uveitis; Latent Infection More Than 1 Year’s Duration; Cardiovascular; Gumma.Drug Dosepenicillin G benzathine 2.4 million U IM weekly × 3 weeksordoxycycline 100 mg PO BID × 4 weeks(c) Neurosyphilis: Includes Posterior Uveitic Involvement.Note: PCN allergic patients may need to be desensitized.Drug Dosepenicillin G 2–4 million U IV Q4 hr × 10–14 days followed by penicillin G benzathine 2.4 MU IM Qweek × 3Antibacterial Agents 9