Douglas J. Rhee, MD

PLUSazithromycin Zithromax 1.2–1.5 gm PO TIDdapsone 100 mg PO QDORAtovaquone Mepron 750 mg PO QIDTake medicine with food to increaseabsorptionSingle drug therapy was effective in phase1 trial; prednisone 40 mg PO QD wasbegun on day 3 7Notes: 1. May consider concurrent treatment with oral prednisone (1 mg/kg/day) for inflammation especially if optic nerve or maculais involved.2. Treat for 4–6 weeks after resolution of signs/symptoms and continue folinic acid one week beyond the discontinuation ofpyrimethamine therapy.(a) Pediatricpyrimethamine Daraprim 2 mg/kg/d × 3 days then 1 mg/kg/day (max 25 mg/day) × 4 weeksPLUSsulfadiazine 4 100–200 mg/kg/day × 4 weeksPLUSfolinic acid 5 10 mg PO QD × 4 weeksNote: Congenitally infected newborns should be treated with pyrimethamine and sulfadiazine every 2–3 days for one yearAntiparasitic Agents 51