Douglas J. Rhee, MD

52(b) Pregnancyspiramycin Rovamycine 3–4 grams/day × 3–4 weeksNote: Intravitreal clindamycin 1.0 mg is another treatment option in pregnant women with ocular toxoplasmosis.1 From Medical Lett 1995;37:99–106.2 From Am J Ophthalmol 1993;115:293.3 From Ophthalmology 1991;98:196.4 If sulfa allergic, may substitute with clindamycin.5 Folinic acid is used to avoid pyrimethamine-induced myelosuppression.6 From Ophthalmology 2005;112:1876–1882.7 From Ophthalmology 1999;106:148–153.B. HELMINTHS(1) Filariasis 1(a) Onchocerciasis (Onchocerca volvulus) (“River Blindness ”)Drug Trade Doseivermectin Mectizan 150 µg/kg × 1, repeated every 6–12 months until asymptomaticNotes: 1. Consider antihistamines or corticosteroids to reduce allergic reaction caused by dead microfilaria.2. Pediatric dosing is the same.