190ReferencesBegemann, H., M. Begemann: Praktische Hämatologie, 10. Aufl. Thieme, Stuttgart1998Begemann, H., J. Rastetter: Klinische Hämatologie, 4. Aufl. Thieme, Stuttgart 1993Bessis, M.: Blood Smears Reinterpreted. Springer, Berlin 1977Binet, J.L., A. Auquier, G. Dighiero et al.: A new prognostic classification <strong>of</strong> chroniclymphocytic leukemia derived from a multivariate survival analysis. Cancer1981; 48(1): 198-206Brücher, H.: Knochenmarkzytologie. Thieme, Stuttgart 1986Classen, M., A. Dierkesmann, H. Heimpel et al.: Rationelle Diagnostik und Therapiein der inneren Medizin. Urben & Schwarzenberg, München 1996Costabel, M.: <strong>Atlas</strong> der bronchoalveolären Lavage. Thieme, Stuttgart 1994Costabel V., J. Guzman: Bronchoalveolar lavage in interstital lung disease. CurrOpin Pulm Med 2001; 7(5): 255-61Durie, B.G.M., S.E. Salmon: A clinical staging system for multiple myeloma. Correlation<strong>of</strong> measured myeloma cell mass with presenting clinical features, responseto treatment, <strong>and</strong> survival. Cancer 1975; 36: 842-854Heckner, F., M. Freund: Praktikum der mikroskopischen Hämatologie. Urban &Schwarzenberg, München 1994Heimpel, H., D. Hoelzer, E. Kleihauer, H. P. Lohrmann: Hämatologie in der Praxis.Fischer, Stuttgart 1996Huber, H., H. Löffler, V. Faber: Methoden der diagnostischen Hämatologie.Springer, Berlin 1994Jaffe, E. S., N. L. Harris, H. Stein, J. W. Vardiman: World Health Organization Classification<strong>of</strong> Tumours. Pathology <strong>and</strong> Genetics <strong>of</strong> Tumours <strong>of</strong> Haematopoietic <strong>and</strong>Lymphoid Tissues. IARC Press, Lyon 2001Lennert, K., A. C. Feller: Non-Hodgkin-Lymphome. Springer, Berlin 1990Löffler, H., J. Rastetter: <strong>Atlas</strong> der klinischen Hämatologie. Springer, Berlin 1999Murphy, S.: Diagnostic criteria <strong>and</strong> prognosis in polycythemia vera <strong>and</strong> essentialthombocythemia. Semin Hematol 1999; 36(1 Suppl 2): 9-13Ovell, S. R., G. Sterrett, M. N. Walters, D. Whitaker: Fine Needle Aspiration Cytology.Churchill Livingstone, Edinburgh London 1992Pearson, T.C., M Messinezy: The diagnostic criteria <strong>of</strong> polycythaemia rubra vera.Leuk Lymphoma 1996;22(Suppl 1): 87-93Pralle, H. B.: Checkliste Hämatologie, 2. Aufl. Thieme, Stuttgart 1991Schmoll, H. J., K. Höffken, K. Possinger: Kompendium internistische Onkologie,3. Bde., 3. Aufl. Springer, Berlin 1999Theml, H., W. Kaboth, H. Begemann: Blutkrankheiten. In Kühn, H. A., J. Schirmeister:Innere Medizin, 5. Aufl. Springer, Berlin 1989Theml, H., H. D. Schick: Praktische Differentialdiagnostik hämatologischer undonkologischer Krankheiten. Thieme, Stuttgart 1998Zucker-Franklin, D., M. F. Greaves, C. E. Grossi, A. M. Marmont: <strong>Atlas</strong> der Blutzellen,2. Aufl. Fischer, Stuttgart 1990
191IndexAActinomycosis 179Addison disease 66Agammaglobulinemia 48Agranulocytosis 48, 86acute 86allergic 8bone marrow analysis 54, 86, 87classification 86subacute 86Alcoholism, chronic 168Allergic processes 8, 44basophilia <strong>and</strong> 124eosinophilia <strong>and</strong> 124Anemia 80, 106–107aplastic 8, 48, 56, 131, 140, 148–150bone marrow analysis 53, 54, 56classification 128congenital dyserythropoietic (CDA)147, 148diagnosis 130–131Diamond–Blackfan 146dimorphic 152hemolytic 131, 140–145causes 142microangiopathic 144, 150with erythrocyte anomalies144–145hemorrhage <strong>and</strong> 131hyperchromic 128, 152–155causes 152hyper-regenerative 128hypochromic 128–139bone marrow analysis 134–137infectious/toxic 131, 134–135, 136iron-deficiency 128–133, 136sideroachrestic 137with hemolysis 138–139hypoplastic 140congenital 146hyporegenerative 128immunohemolytic 8macrocytic 152–153megaloblastic 43, 54, 56, 131,152–154normochromic 128, 140–151bone marrow analysis 140hemolytic 140–145renal 146paraneoplastic 131pernicious 140, 154refractory 106in transformation 108with excess blasts (RAEB) 54, 106with ring sideroblasts 106renal 146secondary 131, 134, 135, 136sickle cell 142, 144, 145sideroachrestic 131, 137sideroblastic 137smoldering 54Anisocytosis 130, 134–135, 137–139,152–153, 170Anulocytes 132, 133Ascites 186–187Auer bodies 89, 96–99Autoantibodies 142Autoimmune processes 8, 180anemia <strong>and</strong> 134autoagglutination 142, 143eosinophilia <strong>and</strong> 124Automated blood count 19–20Azurophilic granules 96, 100BB-lymphocytes 48, 49function 6see also LymphocytesB<strong>and</strong> cells 4, 6, 38–39, 57, 153diagnostic implications 38, 112, 113normal ranges <strong>and</strong> mean values 12Basophilia 124–126Basophilic stippling 134, 135,137–139, 156–157Basophils 44–45, 125
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iiiColor Atlas of HematologyPractic
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vPrefaceOur Current EditionAlthough
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viiContentsPhysiology and Pathophys
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ContentsixAcute Lymphoblastic Leuke
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2Physiology and Pathophysiology of
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4Physiology and Pathophysiology of
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6Physiology and Pathophysiology of
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8Physiology and Pathophysiology of
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10Physiology and Pathophysiology of
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12Physiology and Pathophysiology of
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14Physiology and Pathophysiology of
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16Physiology and Pathophysiology of
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18Physiology and Pathophysiology of
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20Physiology and Pathophysiology of
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22Physiology and Pathophysiology of
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24Physiology and Pathophysiology of
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26Physiology and Pathophysiology of
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Normal Cells of the Blood andHemato
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Normally erythropoiesis takes place
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34Normal Cells of the Blood and Hem
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36Normal Cells of the Blood and Hem
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Advancing nuclear contraction and s
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Note the granulations, inclusions,
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44Normal Cells of the Blood and Hem
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46Normal Cells of the Blood and Hem
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48Normal Cells of the Blood and Hem
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50Normal Cells of the Blood and Hem
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52Normal Cells of the Blood and Hem
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54Normal Cells of the Blood and Hem
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56Normal Cells of the Blood and Hem
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58Normal Cells of the Blood and Hem
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Abnormalities of the White Cell Ser
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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During lymphatic reactive states, v
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Extreme transformation of lymphocyt
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Monotonous proliferation of small l
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Atypical lymphocytes are not part o
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Deep nuclear indentation suggests f
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Cytoplasmic processes the main feat
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Plasmacytoma cannot be diagnosed wi
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Atypias and differential diagnoses
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Bone marrow diagnosis is indicated
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Conspicuously large numbers of mono
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Fundamental characteristic of acute
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The diagnosis of acute leukemia is
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Acute leukemias may also derive fro
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New WHO classification: AML with dy
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The cells in acute lymphocytic leuk
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In unexplained anemia and/or leukoc
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The classification of myelodysplasi
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Prevalence of Polynuclear (Segmente
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Predominance of the granulocytic li
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Prevalence of Polynuclear (Segmente
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Left shift as far as myeloblasts, p
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Bone marrow analysis is not obligat
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In the course of chronic myeloid le
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Enlarged spleen and presence of imm
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Eosinophilia and basophilia are usu
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Erythrocyte and ThrombocyteAbnormal
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Hypochromic Anemias129Insufficient
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Hypochromic Anemias131BSGIron Ferri
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Small, hemoglobin-poor erythrocytes
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Hypochromic erythrocytes of very va
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Hypochromic Anemias137Hypochromic S
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