192IndexBasophils, diagnostic implications 44elevated counts 124–126function 5, 6in chronic myeloid leukemia 118,120, 121normal ranges <strong>and</strong> mean values 13Bicytopenia 106, 149Blast crisisin chronic myeloid leukemia120–121in osteomyelosclerosis 123Blood cell series 2–5, 53regulation <strong>and</strong> dysregulation 7–8see also Erythropoiesis; GranulocytopoiesisBlood countsautomated blood counts 19–20complete blood count (CBC) 25differential diagnosis 62–65differential blood count (DBC)17–19, 25–26indications 27erythrocytes 10, 13, 25leukocytes 14, 16, 25reticulocytes 11, 13, 32thrombocytes 15, 25Blood sample collection 9Blood smear 17–19staining 18, 19Blood–bone marrow barrier, destruction<strong>of</strong> 30, 32, 34Boeck disease 178, 180, 181Bone marrow 52–59analysis 52–59agranulocytosis 54, 86, 87cell density 52chromic myeloid leukemia118–119, 120, 121essential thrombocythemia170–171hypochromic anemias 134–137indications for 26, 27myelodysplasias 108, 109normochromic anemias 140polycythemia vera 162–163red cell series/white cell seriesratios 53, 136space-occupying processes150–151thrombocytopenia 164, 169aplasia 146–150pure red cell aplasia (PRCA)146–148biopsy 20–22, 27cytology 20, 52–55disturbances 8histology 20, 26hyperplasia 149infectious/toxic 134medullary stroma cells 58–59neoplasms 150, 168carcinosis 131, 150–151Bone metastases 150, 168Branchial cyst 179, 184, 185Bronchoalveolar lavage 184–185indications 184Brucellosis 66, 179Bruton disease 48Burkitt lymphoma 71Burr cell 135CCabot ring 156, 157Carcinoma 188, 189bone marrow 131, 150–151metastatic disease 182, 183Cat-scratch disease 179Centroblasts 176Cerebrospinal fluid 188–189Charcot-Leyden crystals 44Chickenpox 66Chromatin structure 4Collagen disease 179Complete blood count (CBC) 25differential diagnosis 62–65Cyclic Murchison syndrome 40Cystbranchial 179, 184, 185retention 184Cytomegalovirus (CMV) infection 66,67, 68, 168DDiagnostic workup 25–27Diamond–Blackfan anemia 146Differential blood count (DBC) 17–19,25–26indications 27DiGeorge disease 48
Index193Disseminated intravascularcoagulopathy (DIC) 144, 167Döhle bodies 39–41Drumstick appendages 42, 43Ductus thyroglossus 184Dyserythropoiesis 102, 106, 109congenital dyserythropoietic anemia(CDA) 147, 148Dysgranulopoiesis 102, 106Dysmegakaryopoiesis 102, 106, 109EElliptocytosis 142Eosinophilia 111, 124, 125cerebrospinal fluid 188Eosinophils 44–45, 125diagnostic implications 44, 56elevated counts 124, 125functions 5, 6in chronic myeloid leukemia 118normal ranges <strong>and</strong> mean values 12Epstein–Barr virus (EBV) infection 66,68–69, 168Erythremia 54, 162–163Erythroblastopenia 146–148Erythroblastophthisis 146Erythroblastosis 8Erythroblasts 30–33, 57acute erythroleukemia 100basophilic 30, 32, 54, 57, 85diagnostic implications 30, 32orthochromatic 31, 32, 54, 57polychromatic 32–33, 35, 54, 57Erythrocytes 7, 33assessment 26basophilic stippling 134, 135,137–139, 156–157counts 10, 13, 25, 128function 7inclusions 156–161iron deficiency <strong>and</strong> 132–133normal ranges <strong>and</strong> mean values 13parameters 10–11red cell distribution width (RDW)11ring-shaped 130, 132, 133tear-drop 115, 123see also AnemiaErythrocytosisprimary 162secondary 162, 163Erythroleukemia 30, 93, 100in normochromic anemia 140Erythrophages 188Erythropoiesis 3, 30–33, 55bone marrow analysis 54, 136iron staining 56, 57, 109dyserythropoiesis 102, 106, 109in hypochromic anemia 136, 138in normochromic anemia 140megaloblastic 54Erythropoietin 146Essential thrombocythemia (ET) 8, 26,56, 114, 170–171diagnosis 170FFaggot cells 99Felty syndrome 179Ferritin granules 56Fibroblastic reticular cells 58, 59Folic acid deficiency 7, 38, 54, 149in hemolytic anemia 140, 141in hyperchromic anemia 152–154thrombocytopenia <strong>and</strong> 168Fragmentocytes 142, 143Fragmentocytosis 144GGaisböck syndrome 53Gaucher syndrome 118Granulocytes 3, 4, 12, 13degrading forms 42functions 5, 6hypersegmented 153–154precursors 34–37see also Basophils; Eosinophils;NeutrophilsGranulocytopenia 66, 86Granulocytopoiesis 3, 5, 34–39bone marrow analysis 54dysgranulopoiesis 102, 106in acute myelomonocytic leukemia98in hypochromic anemia 136Granulocytosis 110Gumprecht's nuclear shadow 74
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iiiColor Atlas of HematologyPractic
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vPrefaceOur Current EditionAlthough
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viiContentsPhysiology and Pathophys
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ContentsixAcute Lymphoblastic Leuke
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2Physiology and Pathophysiology of
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4Physiology and Pathophysiology of
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6Physiology and Pathophysiology of
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8Physiology and Pathophysiology of
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10Physiology and Pathophysiology of
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12Physiology and Pathophysiology of
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14Physiology and Pathophysiology of
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16Physiology and Pathophysiology of
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18Physiology and Pathophysiology of
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20Physiology and Pathophysiology of
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22Physiology and Pathophysiology of
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24Physiology and Pathophysiology of
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26Physiology and Pathophysiology of
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Normal Cells of the Blood andHemato
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Normally erythropoiesis takes place
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34Normal Cells of the Blood and Hem
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36Normal Cells of the Blood and Hem
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Advancing nuclear contraction and s
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Note the granulations, inclusions,
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44Normal Cells of the Blood and Hem
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46Normal Cells of the Blood and Hem
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48Normal Cells of the Blood and Hem
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50Normal Cells of the Blood and Hem
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52Normal Cells of the Blood and Hem
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54Normal Cells of the Blood and Hem
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56Normal Cells of the Blood and Hem
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58Normal Cells of the Blood and Hem
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Abnormalities of the White Cell Ser
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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During lymphatic reactive states, v
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Extreme transformation of lymphocyt
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Monotonous proliferation of small l
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Atypical lymphocytes are not part o
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Deep nuclear indentation suggests f
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Cytoplasmic processes the main feat
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Plasmacytoma cannot be diagnosed wi
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Atypias and differential diagnoses
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Bone marrow diagnosis is indicated
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Conspicuously large numbers of mono
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Predominance of Mononuclear Round t
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Fundamental characteristic of acute
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The diagnosis of acute leukemia is
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Acute leukemias may also derive fro
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New WHO classification: AML with dy
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The cells in acute lymphocytic leuk
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In unexplained anemia and/or leukoc
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The classification of myelodysplasi
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Prevalence of Polynuclear (Segmente
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Predominance of the granulocytic li
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Prevalence of Polynuclear (Segmente
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Left shift as far as myeloblasts, p
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Bone marrow analysis is not obligat
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In the course of chronic myeloid le
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Enlarged spleen and presence of imm
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Eosinophilia and basophilia are usu
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Erythrocyte and ThrombocyteAbnormal
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Hypochromic Anemias129Insufficient
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Hypochromic Anemias131BSGIron Ferri
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Small, hemoglobin-poor erythrocytes
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Hypochromic erythrocytes of very va
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Hypochromic Anemias137Hypochromic S
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Hypochromic anemia without iron def
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