Color Atlas of Hematology - Practical Microscopic and Clinical ...

72Abnormalities of the White Cell SeriesTable 6b T-cell lymphomas (since T-cell lymphomas make up only 10% of all NHLs, this table gives just a briefcharacterization; for markers see Table 7)WHO( Kiel)Classification➤ T-prolymphocytic leukemia➤ Large granular lymphocyte leukemia (LGL)➤ T-cell lymphoblastic leukemiaManifestationLeukemicLeukemicLeukemicClinical characteristicsAggressiveSometimes indolentAggressive➤ Sézary syndrome, mycosis fungoides Cutaneous Chronic, progressive➤ Angioimmunoblastic T-cell lymphoma (AILD) Nodal and ENT Usually aggressive➤ Lymphoblastic T-cell lymphoma➤ T-cell zone lymphoma (nonspecific peripherallymphoma)➤ Lennert lymphoma with multifocal epithelioidcells➤ Large-cell anaplastic lymphoma (ki1)NodalNodalNodalNodalAggressiveSometimes slowlyprogressiveSometimes slowlyprogressiveAggressiveDifferentiation of the Lymphatic Cells and Cell SurfaceMarker Expression in Non-Hodgkin Lymphoma CellsNon-Hodgkin lymphoma cells derive monoclonally from specific stages inthe B- or T-cell differentiation, and their surface markers reflect this. Thesurface markers are identified in immunocytological tests (Table 7) carriedout on heparinized blood or bone marrow spicules.The blastic lymphomas will not be discussed further in the context ofdiagnostics based on blood cell morphology. The findings in the primarilyleukemic forms of the disease, such as lymphoblastic lymphoma, resemblethose for ALL (p. 104). Other blastic lymphomas can usually onlybe diagnosed on the basis of lymph node tissue (Fig. 65). Of course, despiteall the progress in the analysis of blood cell differentiation, often analysisof histological slides in conjunction with the blood analysis is required fora confident diagnosis.